Prevalence of Nonalcoholic Fatty Liver Disease and Its Association With Cardiovascular Disease Among Type 2 Diabetic Patients

I read with interest the articles by Targher et al. (1), which shows that nonalcoholic fatty liver disease (NAFLD) is extremely common in type 2 diabetes and is associated with a higher prevalence of cardiovascular disease (CVD), and by Hu et al. (2), which shows that type 2 diabetes is associated with an increased risk of Parkinson's disease. Neither is surprising, considering society's excessive use of polyunsaturated n-6–rich vegetable oils (a source of linoleic acid, a short-chain n-6 polyunsaturated fatty acid [PUFA]) in place of saturated fats, in addition …

[1]  H. Cortez‐Pinto,et al.  How different is the dietary pattern in non-alcoholic steatohepatitis patients? , 2006, Clinical nutrition.

[2]  D. Guilloteau,et al.  Chronic n-3 polyunsaturated fatty acid diet-deficiency acts on dopamine metabolism in the rat frontal cortex: a microdialysis study , 1998, Neuroscience Letters.

[3]  D. Robbins,et al.  A successful diabetes prevention study in Eskimos: the Alaska Siberia project , 2005, International journal of circumpolar health.

[4]  G. Svegliati-Baroni,et al.  A model of insulin resistance and nonalcoholic steatohepatitis in rats: role of peroxisome proliferator-activated receptor-alpha and n-3 polyunsaturated fatty acid treatment on liver injury. , 2006, The American journal of pathology.

[5]  P. Calder n-3 Fatty acids and cardiovascular disease: evidence explained and mechanisms explored. , 2004, Clinical science.

[6]  S. Innis,et al.  Docosahexaenoic and arachidonic acid prevent a decrease in dopaminergic and serotoninergic neurotransmitters in frontal cortex caused by a linoleic and alpha-linolenic acid deficient diet in formula-fed piglets. , 1999, The Journal of nutrition.

[7]  A. Rajput,et al.  Postmortem brain fatty acid profile of levodopa-treated Parkinson disease patients and parkinsonian monkeys , 2006, Neurochemistry International.

[8]  D. Guilloteau,et al.  Chronic dietary alpha-linolenic acid deficiency alters dopaminergic and serotoninergic neurotransmission in rats. , 1994, The Journal of nutrition.

[9]  R. Heine,et al.  Prevalence of Nonalcoholic Fatty Liver Disease and Its Association With Cardiovascular Disease Among Type 2 Diabetic Patients , 2007, Diabetes Care.