论文信息 - Sugar/steroid/sugar conjugates: sensitivity of lipid binding to sugar structure.

Sugar/steroid/sugar conjugates: sensitivity of lipid binding to sugar structure.

[structure: see text]. Three steroids, each bearing a sugar on rings A and D, have been synthesized. Their effect on the "melting" behavior of a lipid bilayer depends on whether the sugar is glucose, galactose, or mannose. Packing constraints dictate how the lipid bilayer responds to the sugars.

F. Menger | B. Mbadugha | Bessie N. A. Mbadugha

[1] J. Lehn,et al. Synthesis of multitopic bidentate ligands based on alternating pyridine and pyridazine rings , 1999 .

[2] F. Menger,et al. Digitonin as a Chemical Trigger for the Selective Transformation of Giant Vesicles. , 1998, Angewandte Chemie.

[3] K. Mortensen,et al. Solutes in small amounts provide for lipid-bilayer softness: cholesterol, short-chain lipids, and bola lipids , 1996, European Biophysics Journal.

[4] Kazuo Yamasaki,et al. Saponins Used in Traditional and Modern Medicine , 1996, Advances in Experimental Medicine and Biology.

[5] D. Boger,et al. Singlet oxygen oxidation of bipyrroles: total synthesis of d,l- and meso-isochrysohermidin , 1993 .

[6] J. Randolph,et al. Application of the glycal assembly strategy to the synthesis of a branched oligosaccharide: the first synthesis of a complex saponin , 1993 .

[7] R. Schmidt,et al. Glycosyl Imidates, 61. – Synthesis of the Hexasaccharide Moiety of the Saponin Holotoxin A , 1993 .

[8] P. Yager,et al. Perturbation of the chain melting transition of DPPC by galactose, agarose and Laurdan as determined by differential scanning calorimetry. , 1993, Biochimica et biophysica acta.

[9] M. Nishizawa,et al. Total synthesis of intensely sweet saponin, osladin , 1993 .

[10] Erich Sackmann,et al. Bending elastic moduli of lipid bilayers : modulation by solutes , 1990 .