The proliferation of Internet information technology has fundamentally changed the way of learning. It is now a research hotspot to improve teaching effect in col-leges with Internet information technology. Starting from the actual needs of col-lege teaching, this paper designs a college teaching system based on various In-ternet information technologies. Specifically, the front end was developed under the lightweight progressive Vue.js framework, which relies on the model–view–view model (MVVM); the overall structure of the system was set up based on the browser-server (B/S) architecture; the system functions were realized through HTML5, Node.js and database technology; the compatibility between mobile terminal and desktop was realized under Bootstrap. The system test shows that the Vue.js-based college teaching system operated stably, achieved the design goals and satisfied user demand. The research findings shed important new light on modernization and quality of college teaching.