Pre-eclampsia presenting with deep jaundice.

Pre-eclampsia complicated by deep jaundice occurred in a previously healthy primigravida. The main aetiological factor was disseminated intravascular coagulation; this caused both haemolysis and liver cell necrosis. Liver biopsy showed fibrin thrombi in the capillaries with microhaemorrhages and loss of periportal liver cells. The jaundice was attributed to both haemolytic and hepatocellular processes. Organs other than the liver were relatively unaffected.

[1]  H. G. Dixon,et al.  HEPARIN TREATMENT OF HAEMOLYSIS AND THROMBOCYTOPENIA IN PRE‐ECLAMPSIA , 1967, The Journal of obstetrics and gynaecology of the British Commonwealth.

[2]  J. Brown,et al.  PLASMA-RENIN IN NORMAL PREGNANCY , 1963 .

[3]  F. Darnis.  [Jaundice in pregnancy]. , 1977, La Revue du praticien.

[4]  E. Page.  ON THE PATHOGENESIS OF PRE‐ECLAMPSIA AND ECLAMPSIA * , 1972, The Journal of obstetrics and gynaecology of the British Commonwealth.

[5]  P. Vassalli,et al.  THE PATHOGENIC ROLE OF FIBRIN DEPOSITION IN THE GLOMERULAR LESIONS OF TOXEMIA OF PREGNANCY , 1963, The Journal of experimental medicine.

[6]  T. Gillman,et al.  Plasma fibrinogen activity in pregnancy. , 1959, Lancet.

[7]  R. Gallegos,et al.  Angiotensin blood levels in normal and toxemic pregnancies. , 1967, American journal of obstetrics and gynecology.

[8]  M. Watsa,et al.  Liver in normal pregnancy, pre-eclampsia, and eclampsia. , 1958, Lancet.

[9]  J. P. Fletcher.  ECLAMPSIA AND MICROANGIOPATHIC HAEMOLYTIC ANAEMIA , 1971, The Medical journal of Australia.