Frequency-specific meso-scale structure of spontaneous oscillatory activity in the human brain

Recent studies provided novel insights into the meso-scale organization of the brain, highlighting the co-occurrence of different structures: classic assortative (modular), disassortative and core-periphery. However, the spectral properties of the brain meso-scale remain unexplored. To fill this knowledge gap, we investigated how this meso-scale structure is organized across the frequency domain. We analyzed the resting state activity of healthy participants with source-localized high-density electroencephalography signals. Then, we inferred the community structure using weighted stochastic block-modelling to capture the landscape of meso-scale structures across the frequency domain. Despite meso-scale modalities were mixed over the entire spectrum, we found a selective increase of disassortativity in the delta/theta bands, and of core-peripheriness in the low/high gamma bands. We observed, for the first time, that the brain at rest shows frequency-specific meso-scale organizations supporting spatially distributed and local information processing, shedding new light on how the brain coordinates information flow.

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