论文信息 - p53 and apoptosis: it's not just in the nucleus anymore.

p53 and apoptosis: it's not just in the nucleus anymore.

The tumor suppressor p53 triggers apoptosis in response to a variety of stress stimuli. Its role as a transcription factor modulating gene expression has been clearly implicated in this process. Two recent publications now argue for an additional direct role of p53 at the mitochondria in inducing apoptosis.

J. Manfredi | James J Manfredi

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[3] N D Marchenko,et al. Death Signal-induced Localization of p53 Protein to Mitochondria , 2000, The Journal of Biological Chemistry.

[4] M. Murphy,et al. The codon 72 polymorphic variants of p53 have markedly different apoptotic potential , 2003, Nature Genetics.

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