Is there a role for NK cells in the pathogenesis of multiple sclerosis? A case study.

[1]  D. Paty,et al.  A role for natural killer cells in the immunopathogenesis of multiple sclerosis , 1998, Journal of Neuroimmunology.

[2]  A. Ben-nun,et al.  Predominance of the autoimmune response to myelin oligodendrocyte glycoprotein (MOG) in multiple sclerosis: Reactivity to the extracellular domain of MOG is directed against three main regions , 1997, European journal of immunology.

[3]  R. Biassoni,et al.  Major histocompatibility complex class I‐specific receptors on human natural killer and T lymphocytes , 1997, Immunological reviews.

[4]  H. McFarland,et al.  A novel population of CD4+CD56+ myelin-reactive T cells lyses target cells expressing CD56/neural cell adhesion molecule. , 1996, Journal of immunology.

[5]  L. Weiner,et al.  Isolation and characterization of autoreactive moteolioid protein‐peptide specific T‐cell clones from multiple sclerosis patients , 1995, Neurology.

[6]  A. Sette,et al.  T cell recognition of immunodominant and cryptic proteolipid protein epitopes in humans , 1994, Journal of Neuroimmunology.

[7]  K. Parker,et al.  Autoreactive CD8+ cell responses to human myelin protein-derived peptides , 1994, Journal of Neuroimmunology.

[8]  V Balasingam,et al.  Reactive astrogliosis in the neonatal mouse brain and its modulation by cytokines , 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[9]  N. Yanagisawa,et al.  Increased levels of intercellular adhesion molecule‐1 (ICAM‐1) and tumor necrosis factor receptor in the cerebrospinal fluid of patients with multiple sclerosis , 1993, Neurology.

[10]  V. Barnaba,et al.  Expression of conformationally constrained adhesion peptide in an antibody CDR loop and inhibition of natural killer cell cytotoxic activity by an antibody antigenized with the RGD motif. , 1993, The EMBO journal.

[11]  P. Parham,et al.  Specificity of HLA class I antigen recognition by human NK clones: evidence for clonal heterogeneity, protection by self and non-self alleles, and influence of the target cell type , 1993, The Journal of experimental medicine.

[12]  H. Hartung Immune‐mediated demyelination , 1993, Annals of neurology.

[13]  E. Thompson,et al.  Increased levels of circulating ICAM-1 in serum and cerebrospinal fluid of patients with active multiple sclerosis. Correlation with TNF-α and blood-brain barrier damage , 1993, Journal of Neuroimmunology.

[14]  H. Weiner,et al.  Double-blind pilot trial of oral tolerization with myelin antigens in multiple sclerosis. , 1993, Science.

[15]  A. Cross,et al.  Phosphatidylserine, a putative inhibitor of tumor necrosis factor, prevents autoimmune demyelination , 1993, Neurology.

[16]  G. Grau,et al.  Tumor necrosis factor alpha production as a possible predictor of relapse in patients with multiple sclerosis. , 1992, European cytokine network.

[17]  Y. Saeki,et al.  Transfer of multiple sclerosis into severe combined immunodeficiency mice by mononuclear cells from cerebrospinal fluid of the patients. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[18]  J. Abrams,et al.  Strategies of Anti‐Cytokine Monoclonal Antibody Development: Immunoassay of IL‐10 and IL‐5 in Clinical Samples , 1992, Immunological reviews.

[19]  J. Guardiola,et al.  Evidence of a natural killer (NK) cell repertoire for (allo) antigen recognition: definition of five distinct NK-determined allospecificities in humans , 1992, The Journal of experimental medicine.

[20]  J. Ritz,et al.  Differential responses to interleukin 2 define functionally distinct subsets of human natural killer cells , 1992, European journal of immunology.

[21]  A. Cross,et al.  Anti—tumor necrosis factor therapy abrogates autoimmune demyelination , 1991, Annals of neurology.

[22]  H. Weiner,et al.  T-cell recognition of myelin basic protein. , 1991, Immunology today.

[23]  V. Barnaba,et al.  Tumour necrosis factor‐alpha synthesis by cerebrospinal‐fluid‐derived T cell clones from patients with multiple sclerosis , 1991, Italian journal of neurological sciences.

[24]  C. Brosnan,et al.  Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions. , 1991, The Journal of clinical investigation.

[25]  Eric O Long,et al.  A myelin basic protein peptide is recognized by cytotoxic T cells in the context of four HLA-DR types associated with multiple sclerosis , 1991, The Journal of experimental medicine.

[26]  L. Kappos,et al.  Myelin autoreactivity in multiple sclerosis: recognition of myelin basic protein in the context of HLA-DR2 products by T lymphocytes of multiple-sclerosis patients and healthy donors. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[27]  J. Seidman,et al.  Shared human T cell receptor V beta usage to immunodominant regions of myelin basic protein. , 1990, Science.

[28]  C. Brosnan,et al.  Proliferation of astrocytes in vitro in response to cytokines. A primary role for tumor necrosis factor. , 1990, Journal of immunology.

[29]  G. Trinchieri,et al.  Biology of Natural Killer Cells , 1989, Advances in Immunology.

[30]  L. Hood,et al.  Restricted use of T cell receptor V genes in murine autoimmune encephalomyelitis raises possibilities for antibody therapy , 1988, Cell.

[31]  H. Mcdevitt,et al.  Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention , 1988, Cell.

[32]  J. Richert,et al.  Peptide specificities of myelin basic protein‐reactive human T‐cell clones , 1988, Neurology.

[33]  E. Tournier-Lasserve,et al.  Human T‐cell response to myelin basic protein in multiple sclerosis patients and healthy subjects , 1988, Journal of neuroscience research.

[34]  W. V. van Blitterswijk,et al.  Serum-free medium for generation and propagation of functional human cytotoxic and helper T cell clones. , 1984, Journal of immunological methods.

[35]  L. Abruzzo,et al.  Homeostasis of the antibody response: immunoregulation by NK cells. , 1983, Science.

[36]  B. Zweiman,et al.  Isolation of myelin basic protein-reactive T-cell lines from normal human blood. , 1983, Cellular immunology.

[37]  B. Arnason Relevance of experimental allergic encephalomyelitis to multiple sclerosis. , 1983, Neurologic clinics.

[38]  E. Reinherz,et al.  Multiple sclerosis: distribution of T cell subsets within active chronic lesions. , 1983, Science.

[39]  D. McFarlin,et al.  Multiple sclerosis (first of two parts). , 1982, The New England journal of medicine.

[40]  E. Alvord,et al.  THE ENCEPHALOMYELITIC ACTIVITY OF MYELIN ISOLATED BY ULTRACENTRIFUGATION , 1962, The Journal of experimental medicine.

[41]  F. Barkhof,et al.  Increased Production of Tumor Necrosis Factor (cid:97) , and Not of Interferon (cid:103) , Preceding Disease Activity in Patients With Multiple Sclerosis , 2000 .

[42]  L. Steinman,et al.  The T lymphocyte in experimental allergic encephalomyelitis. , 1990, Annual review of immunology.

[43]  Y. Shoenfeld,et al.  Natural killer cells and autoimmunity , 1989, Immunologic research.

[44]  A. Boese Search for the cause of multiple sclerosis and other chronic diseases of the central nervous system , 1980 .