Drug penetration in solid tumours
暂无分享,去创建一个
[1] S. Ametamey,et al. Ionizing Radiation Antagonizes Tumor Hypoxia Induced by Antiangiogenic Treatment , 2006, Clinical Cancer Research.
[2] Limor Chen,et al. Targeted anti-vascular endothelial growth factor receptor-2 therapy leads to short-term and long-term impairment of vascular function and increase in tumor hypoxia. , 2006, Cancer research.
[3] M. Dewhirst,et al. Tumor vascular permeability, accumulation, and penetration of macromolecular drug carriers. , 2006, Journal of the National Cancer Institute.
[4] Wilson Mok,et al. Degradation of fibrillar collagen in a human melanoma xenograft improves the efficacy of an oncolytic herpes simplex virus vector. , 2006, Cancer research.
[5] I. Tannock,et al. Inhibition of endosomal sequestration of basic anticancer drugs: influence on cytotoxicity and tissue penetration , 2006, British Journal of Cancer.
[6] A. Minchinton,et al. Tirapazamine causes vascular dysfunction in HCT-116 tumour xenografts. , 2006, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.
[7] I. Tannock,et al. The penetration of anticancer drugs through tumor tissue as a function of cellular adhesion and packing density of tumor cells. , 2006, Cancer research.
[8] Lothar Lilge,et al. The Distribution of the Anticancer Drug Doxorubicin in Relation to Blood Vessels in Solid Tumors , 2005, Clinical Cancer Research.
[9] J. Greef,et al. Rescuing drug discovery: in vivo systems pathology and systems pharmacology , 2005, Nature Reviews Drug Discovery.
[10] I. Tannock,et al. Effect of the Selective Estrogen Receptor Modulator Arzoxifene on Repopulation of Hormone-Responsive Breast Cancer Xenografts between Courses of Chemotherapy , 2005, Clinical Cancer Research.
[11] Neil Desai,et al. Phase I and pharmacokinetics trial of ABI-007, a novel nanoparticle formulation of paclitaxel in patients with advanced nonhematologic malignancies. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[12] Greg Yothers,et al. Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. , 2005, The New England journal of medicine.
[13] M. Dowsett,et al. Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer. , 2005, The New England journal of medicine.
[14] I. Tannock,et al. Repopulation of cancer cells during therapy: an important cause of treatment failure , 2005, Nature Reviews Cancer.
[15] Michael Dean,et al. Tumour stem cells and drug resistance , 2005, Nature Reviews Cancer.
[16] W. Wilson,et al. Extravascular transport of drugs in tumor tissue: effect of lipophilicity on diffusion of tirapazamine analogues in multicellular layer cultures. , 2005, Journal of medicinal chemistry.
[17] Lei Xu,et al. Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases. , 2004, Cancer cell.
[18] F. Martin,et al. Pegylated liposomal doxorubicin: proof of principle using preclinical animal models and pharmacokinetic studies. , 2004, Seminars in oncology.
[19] R. Gillies,et al. Why do cancers have high aerobic glycolysis? , 2004, Nature Reviews Cancer.
[20] Kristian Pietras,et al. High interstitial fluid pressure — an obstacle in cancer therapy , 2004, Nature Reviews Cancer.
[21] Janet E. Husband,et al. Imaging in Oncology , 2004 .
[22] A. Minchinton,et al. Microregional Effects of Gemcitabine in HCT-116 Xenografts , 2004, Cancer Research.
[23] A. Minchinton,et al. Direct Assessment of Drug Penetration into Tissue Using a Novel Application of Three-Dimensional Cell Culture , 2004, Cancer Research.
[24] J. Berlin,et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. , 2004, The New England journal of medicine.
[25] W. Wilson,et al. Oxygen Dependence of the Metabolic Activation and Cytotoxicity of Tirapazamine: Implications for Extravascular Transport andActivity in Tumors , 2004, Radiation research.
[26] Rakesh K. Jain,et al. Vascular Normalization by Vascular Endothelial Growth Factor Receptor 2 Blockade Induces a Pressure Gradient Across the Vasculature and Improves Drug Penetration in Tumors , 2004, Cancer Research.
[27] J. Brown,et al. Exploiting tumour hypoxia in cancer treatment , 2004, Nature Reviews Cancer.
[28] Rakesh K. Jain,et al. Pathology: Cancer cells compress intratumour vessels , 2004, Nature.
[29] Ricky T. Tong,et al. Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer , 2004, Nature Medicine.
[30] W. Denny,et al. Multicellular resistance to tirapazamine is due to restricted extravascular transport: a pharmacokinetic/pharmacodynamic study in HT29 multicellular layer cultures. , 2003, Cancer research.
[31] Helen E. Burston,et al. Tumor distribution of bromodeoxyuridine-labeled cells is strongly dose dependent. , 2003, Cancer research.
[32] Jessie L.-S. Au,et al. Drug Delivery and Transport to Solid Tumors , 2003, Pharmaceutical Research.
[33] Rakesh K Jain,et al. Molecular regulation of vessel maturation , 2003, Nature Medicine.
[34] Brian Seed,et al. Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation , 2003, Nature Medicine.
[35] S. Gambhir. Molecular imaging of cancer with positron emission tomography , 2002, Nature Reviews Cancer.
[36] R. Jain,et al. Comparison of IgG diffusion and extracellular matrix composition in rhabdomyosarcomas grown in mice versus in vitro as spheroids reveals the role of host stromal cells , 2002, British Journal of Cancer.
[37] Dai Fukumura,et al. Dissecting tumour pathophysiology using intravital microscopy , 2002, Nature Reviews Cancer.
[38] Lei Xu,et al. Tumour biology: Herceptin acts as an anti-angiogenic cocktail , 2002, Nature.
[39] Ian F Tannock,et al. Limited penetration of anticancer drugs through tumor tissue: a potential cause of resistance of solid tumors to chemotherapy. , 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.
[40] Lyndsay N Harris,et al. Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer. , 2002, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[41] A. Oloumi,et al. Identification of genes differentially expressed in V79 cells grown as multicell spheroids , 2002, International journal of radiation biology.
[42] Rakesh K. Jain,et al. Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy , 2001, Nature Medicine.
[43] W. Wilson,et al. Extravascular transport of the DNA intercalator and topoisomerase poison N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide (DACA): diffusion and metabolism in multicellular layers of tumor cells. , 2001, The Journal of pharmacology and experimental therapeutics.
[44] M. Wientjes,et al. Enhancement of paclitaxel delivery to solid tumors by apoptosis-inducing pretreatment: effect of treatment schedule. , 2001, The Journal of pharmacology and experimental therapeutics.
[45] R. Fisher,et al. Phase I trial of concurrent tirapazamine, cisplatin, and radiotherapy in patients with advanced head and neck cancer. , 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[46] R. Jain,et al. Absence of functional lymphatics within a murine sarcoma: a molecular and functional evaluation. , 2000, Cancer research.
[47] R. Jain,et al. Role of extracellular matrix assembly in interstitial transport in solid tumors. , 2000, Cancer research.
[48] R K Jain,et al. Openings between defective endothelial cells explain tumor vessel leakiness. , 2000, The American journal of pathology.
[49] I. Tannock,et al. The influence of expression of P‐glycoprotein on the penetration of anticancer drugs through multicellular layers , 2000, International journal of cancer.
[50] R K Jain,et al. Taxane-induced apoptosis decompresses blood vessels and lowers interstitial fluid pressure in solid tumors: clinical implications. , 1999, Cancer research.
[51] M. Wientjes,et al. Determinants of paclitaxel penetration and accumulation in human solid tumor. , 1999, The Journal of pharmacology and experimental therapeutics.
[52] J. Lankelma,et al. Doxorubicin gradients in human breast cancer. , 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.
[53] I. Tannock,et al. Penetration of anticancer drugs through solid tissue: a factor that limits the effectiveness of chemotherapy for solid tumors. , 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.
[54] K. Hicks,et al. Measurement of extravascular drug diffusion in multicellular layers. , 1999, British journal of cancer.
[55] B. Dubray,et al. Reproducibility of measurements of potential doubling time of tumour cells in the multicentre National Cancer Institute protocol T92-0045 , 1999, British Journal of Cancer.
[56] M. Dewhirst,et al. Temporal changes in PO2 of R3230AC tumors in Fischer-344 rats. , 1998, International journal of radiation oncology, biology, physics.
[57] W. Wilson,et al. Extravascular diffusion of tirapazamine: effect of metabolic consumption assessed using the multicellular layer model. , 1998, International journal of radiation oncology, biology, physics.
[58] R. Kerbel,et al. Reversal of intrinsic and acquired forms of drug resistance by hyaluronidase treatment of solid tumors. , 1998, Cancer letters.
[59] M C Weissler,et al. Hypoxia and vascular endothelial growth factor expression in human squamous cell carcinomas using pimonidazole as a hypoxia marker. , 1998, Cancer research.
[60] A. Fyles,et al. Interstitial fluid pressure in cervical carcinoma , 1998, Cancer.
[61] P. Loadman,et al. Evaluation of a novel in vitro assay for assessing drug penetration into avascular regions of tumours. , 1998, British Journal of Cancer.
[62] R. Jain,et al. Delivery of molecular and cellular medicine to solid tumors. , 1998, Journal of controlled release : official journal of the Controlled Release Society.
[63] R. Jain,et al. Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[64] A. Giaccia,et al. The unique physiology of solid tumors: opportunities (and problems) for cancer therapy. , 1998, Cancer research.
[65] R. Schwendener,et al. Pharmacokinetic studies of mitoxantrone and one of its metabolites in serum and urine in patients with advanced breast cancer , 1998, European Journal of Clinical Pharmacology.
[66] M. Manfait,et al. Characterization of Acidic Vesicles in Multidrug-resistant and Sensitive Cancer Cells by Acridine Orange Staining and Confocal Microspectrofluorometry , 1997, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.
[67] H. Hollema,et al. Immunocytochemical analysis of cisplatin-induced platinum-DNA adducts with double-fluorescence video microscopy. , 1997, British Journal of Cancer.
[68] R. Jain,et al. Delivery of Molecular and Cellular Medicine to Solid Tumors , 1997, Advanced drug delivery reviews.
[69] Rakesh K. Jain,et al. Interstitial pH and pO2 gradients in solid tumors in vivo: High-resolution measurements reveal a lack of correlation , 1997, Nature Medicine.
[70] R. Kerbel,et al. Induction and reversal of cell adhesion-dependent multicellular drug resistance in solid breast tumors. , 1996, Human cell.
[71] K. Hicks,et al. Multicellular membranes as an in vitro model for extravascular diffusion in tumours. , 1996, The British journal of cancer. Supplement.
[72] R K Jain,et al. Biodistribution of monoclonal antibodies: scale-up from mouse to human using a physiologically based pharmacokinetic model. , 1995, Cancer research.
[73] C. Koch,et al. Oxygen dependence of cellular uptake of EF5 [2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)a cet amide] : analysis of drug adducts by fluorescent antibodies vs bound radioactivity. , 1995, British Journal of Cancer.
[74] W. Panje,et al. In vivo labelling with halogenated pyrimidines of squamous cell carcinomas and adjacent non‐involved mucosa of head and neck region , 1995, Cell proliferation.
[75] R K Jain,et al. Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size. , 1995, Cancer research.
[76] D. Kerr,et al. Quinidine as a resistance modulator of epirubicin in advanced breast cancer: mature results of a placebo-controlled randomized trial. , 1994, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[77] R K Jain,et al. Barriers to drug delivery in solid tumors. , 1994, Scientific American.
[78] P. Olive,et al. Drug and radiation resistance in spheroids: cell contact and kinetics , 1994, Cancer and Metastasis Reviews.
[79] R. Milroy,et al. A randomised clinical study of verapamil in addition to combination chemotherapy in small cell lung cancer. West of Scotland Lung Cancer Research Group, and the Aberdeen Oncology Group. , 1993, British Journal of Cancer.
[80] G. Rosner,et al. Measurement of material extravasation in microvascular networks using fluorescence video-microscopy. , 1993, Microvascular research.
[81] J. Brown,et al. SR 4233 (tirapazamine): a new anticancer drug exploiting hypoxia in solid tumours. , 1993, British Journal of Cancer.
[82] P. Workman,et al. Examination by laser scanning confocal fluorescence imaging microscopy of the subcellular localisation of anthracyclines in parent and multidrug resistant cell lines. , 1993, British Journal of Cancer.
[83] B. Teicher,et al. Acquired multicellular-mediated resistance to alkylating agents in cancer. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[84] R. Jain,et al. Angiogenesis, microvascular architecture, microhemodynamics, and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice. , 1992, Cancer research.
[85] R K Jain,et al. Microvascular pressure is the principal driving force for interstitial hypertension in solid tumors: implications for vascular collapse. , 1992, Cancer research.
[86] M. Dewhirst,et al. Perivascular oxygen tensions in a transplantable mammary tumor growing in a dorsal flap window chamber. , 1992, Radiation research.
[87] G. Aherne,et al. Visualisation of doxorubicin in human and animal tissues and in cell cultures by immunogold-silver staining. , 1992, British Journal of Cancer.
[88] P. Noker,et al. Diversity of penetration of anti‐cancer agents into solid tumours , 1991, Cell proliferation.
[89] K. Väänänen,et al. Omeprazole and bafilomycin, two proton pump inhibitors: differentiation of their effects on gastric, kidney and bone H(+)-translocating ATPases. , 1991, Biochimica et biophysica acta.
[90] D. Chaplin,et al. Intermittent blood flow in the KHT sarcoma--flow cytometry studies using Hoechst 33342. , 1990, British Journal of Cancer.
[91] B. Teicher,et al. Tumor resistance to alkylating agents conferred by mechanisms operative only in vivo. , 1990, Science.
[92] I. Tannock,et al. Acid pH in tumors and its potential for therapeutic exploitation. , 1989, Cancer research.
[93] R. Sutherland. Cell and environment interactions in tumor microregions: the multicell spheroid model. , 1988, Science.
[94] A. Begg,et al. Immunocytochemical detection of interaction products of cis-diamminedichloroplatinum(II) and cis-diammine(1,1-cyclobutanedicarboxylato)platinum(II) with DNA in rodent tissue sections. , 1987, Cancer research.
[95] V. Marks,et al. Immunocytochemical localisation of VP16-213 in normal and malignant tissues. , 1987, Cancer letters.
[96] R K Jain,et al. Transport of molecules in the tumor interstitium: a review. , 1987, Cancer research.
[97] F. Buchegger,et al. Penetration and binding of radiolabeled anti-carcinoembryonic antigen monoclonal antibodies and their antigen binding fragments in human colon multicellular tumor spheroids. , 1987, Cancer research.
[98] D. Chaplin,et al. Intermittent blood flow in a murine tumor: radiobiological effects. , 1987, Cancer research.
[99] R. Durand. Chemosensitivity testing in V79 spheroids: drug delivery and cellular microenvironment. , 1986, Journal of the National Cancer Institute.
[100] M. Bally,et al. Uptake of adriamycin into large unilamellar vesicles in response to a pH gradient. , 1986, Biochimica et biophysica acta.
[101] R. Jain,et al. Microvascular permeability of normal and neoplastic tissues. , 1986, Microvascular research.
[102] D. Chaplin,et al. Cell selection from a murine tumour using the fluorescent probe Hoechst 33342. , 1985, British Journal of Cancer.
[103] C. Erlichman,et al. Cytotoxicity of adriamycin in MGH-U1 cells grown as monolayer cultures, spheroids, and xenografts in immune-deprived mice. , 1984, Cancer research.
[104] J. Denekamp,et al. Endothelial-cell proliferation in experimental tumours. , 1982, British Journal of Cancer.
[105] MANUAL OF SYMBOLS, EQUATIONS & DEFINITIONS IN PHARMACOKINETICS , 1982, Journal of clinical pharmacology.
[106] R. Durand. Use of Hoechst 33342 for cell selection from multicell systems. , 1982, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.
[107] R. Durand. Flow cytometry studies of intracellular adriamycin in multicell spheroids in vitro. , 1981, Cancer research.
[108] S. Ohkuma,et al. Effect of weak bases on the intralysosomal pH in mouse peritoneal macrophages , 1981, The Journal of cell biology.
[109] J. Carlsson,et al. Penetration of substances into tumor tissue—A methodological study on cellular spheroids , 1981, In Vitro.
[110] E. Wibe. Resistance to vincristine of human cells grown as multicellular spheroids. , 1980, British Journal of Cancer.
[111] R. Weichselbaum,et al. Limited penetration of methotrexate into human osteosarcoma spheroids as a proposed model for solid tumor resistance to adjuvant chemotherapy. , 1980, Cancer research.
[112] J. Doroshow,et al. Pharmacokinetics of adriamycin and tissue penetration in murine ovarian cancer. , 1979, Cancer research.
[113] R. Sutherland,et al. Resistance to adriamycin in multicellular spheroids. , 1979, International journal of radiation oncology, biology, physics.
[114] D. Hirst,et al. TUMOUR CELL PROLIFERATION IN RELATION TO THE VASCULATURE , 1979, Cell and tissue kinetics.
[115] I. Tannock,et al. Cell kinetics and chemotherapy: a critical review. , 1978, Cancer treatment reports.
[116] N. Bachur,et al. Cytofluorescence localization of adriamycin and daunorubicin. , 1974, Cancer Research.
[117] I. Tannock,et al. THE RELATION BETWEEN CELL PROLIFERATION AND THE VASCULAR SYSTEM IN A TRANSPLANTED MOUSE MAMMARY TUMOUR , 2007 .
[118] B. Sylvén,et al. On the Access of Blood-Borne Dyes to Various Tumour Regions , 1962, British Journal of Cancer.
[119] W. Bottomley,et al. A Kinin in Apple Fruitlets , 1959, Nature.
[120] B. Sylvén,et al. A Rapid Method for studying Tumour Blood Supply using Systemic Dyes , 1959, Nature.
[121] L. H. Gray,et al. The Histological Structure of Some Human Lung Cancers and the Possible Implications for Radiotherapy , 1955, British Journal of Cancer.
[122] R. Durand. Slow penetration of anthracyclines into spheroids and tumors: a therapeutic advantage? , 2008, Cancer Chemotherapy and Pharmacology.
[123] R. Fisher,et al. Tirapazamine, Cisplatin, and Radiation versus Fluorouracil, Cisplatin, and Radiation in patients with locally advanced head and neck cancer: a randomized phase II trial of the Trans-Tasman Radiation Oncology Group (TROG 98.02). , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[124] D. Kerr,et al. Aspects of cytotoxic drug penetration, with particular reference to anthracyclines , 2004, Cancer Chemotherapy and Pharmacology.
[125] J. Carlsson,et al. Relations between the penetration, binding and average concentration of cytostatic drugs in human tumour spheroids , 2004, Cancer Chemotherapy and Pharmacology.
[126] P. Noker,et al. Variability of tumor response to chemotherapy II. Contribution of tumor heterogeneity , 2004, Cancer Chemotherapy and Pharmacology.
[127] John E. Moulder,et al. Tumor hypoxia: its impact on cancer therapy , 2004, Cancer and Metastasis Reviews.
[128] Jörgen Carlsson,et al. Penetration and binding of vinblastine and 5-fluorouracil in cellular spheroids , 2004, Cancer Chemotherapy and Pharmacology.
[129] D. Grahame-Smith. Preclinical toxicological testing and safeguards in clinical trials , 2004, European Journal of Clinical Pharmacology.
[130] R. Gillies,et al. Microenvironmental and cellular consequences of altered blood flow in tumours. , 2003, The British journal of radiology.
[131] Adrian L. Harris,et al. Hypoxia — a key regulatory factor in tumour growth , 2002, Nature Reviews Cancer.
[132] I. Tannock,et al. Factors that influence the penetration of methotrexate through solid tissue , 2001, International journal of cancer.
[133] P. Carmeliet,et al. In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy , 2001, Nature Medicine.
[134] A. Minchinton,et al. Measurement of delivery and metabolism of tirapazamine to tumour tissue using the multilayered cell culture model , 1999, Cancer Chemotherapy and Pharmacology.
[135] K. Clow,et al. Multilayers of cells growing on a permeable support. An in vitro tumour model. , 1997, Acta oncologica.
[136] J. Brown,et al. NCI's anticancer drug screening program may not be selecting for clinically active compounds. , 1997, Oncology research.
[137] P. Hunter,et al. An experimental and mathematical model for the extravascular transport of a DNA intercalator in tumours. , 1997, British Journal of Cancer.
[138] J. Babich,et al. Differential penetration of targeting agents into multicellular spheroids derived from human neuroblastoma. , 1991, Progress in clinical and biological research.
[139] R. Jain,et al. Microvascular architecture in a mammary carcinoma: branching patterns and vessel dimensions. , 1991, Cancer research.
[140] M. Trotter,et al. Evidence for intermittent radiobiological hypoxia in experimental tumour systems. , 1989, Biomedica biochimica acta.
[141] D. Kerr,et al. Cytotoxic drug penetration studies in multicellular tumour spheroids. , 1988, Xenobiotica; the fate of foreign compounds in biological systems.
[142] R. Durand. Variable radiobiological responses of spheroids. , 1980, Radiation research.
[143] R. Jain,et al. Mass transport in tumors: characterization and applications to chemotherapy. , 1980, Advances in cancer research.
[144] J. Gross,et al. Dynamics of microvascular flow in implanted mouse mammary tumours. , 1977, Bibliotheca anatomica.
[145] Durand Re,et al. Radiation response of multicell spheroids--an in vitro tumour model. , 1976 .
[146] R. Sutherland,et al. Radiation response of multicell spheroids--an in vitro tumour model. , 1976, Current topics in radiation research quarterly.
[147] I. Tannock,et al. The proliferation of capillary endothelial cells. , 1972, Cancer research.
[148] John Crank,et al. The Mathematics Of Diffusion , 1956 .