Nonparametric estimation in nonlinear mixed effects models

A nonparametric approach is developed herein to estimate parameters in nonlinear mixed effects models. Asymptotic properties of the nonparametric maximum likelihood estimators and associated computational algorithms are provided. Empirical Bayes estimators of functionals of the random effects are also developed. Applications to population pharmacokinetics are given. Copyright Biometrika Trust 2003, Oxford University Press.

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