In order to design practice of automated multilayer garage based on S3C2440, ARM industrial control panel for large-scale automated multilayer garage was designed, it’s structure and function were analyzed, and the development environment of the system as well as the control layer-built and administration flow chart were introduced. The system structure was realized with formation, dividing into three stories as of administration, monitoring, and execution in accordance with the function. The system was composed of such subsystems as upper-level real time monitoring, garage management, management information, field spot industrial bus communication, and identification of in/out personality. It was shown by the applying practice that this system possessed expansibility, publicity, and operational convenience.