Hypnosis regulation in presence of saturation, surgical stimulation and additional bolus infusion

Abstract The closed loop regulation of hypnosis implies the mixed effect of the actions dictated by a software based controller, and by the expert knowledge of the anesthesiologist. Other effects such as slew rate limitations due to resolution limits or saturation of the pump infusion system are also present in practice. Almost without exception, the actions of the anesthesiologist and other hardware limitations are not taken into account by the software based controller, hence they are regarded as disturbances. In this work, a PID controller is implemented to investigate the effects of such additional features in the closed loop dynamics. The results are discussed based on simulation study on a linear patient dynamic model.

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