Unique gene-silencing and structural properties of 2'-fluoro-modified siRNAs.
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K. G. Rajeev | M. Manoharan | M. Egli | K. Charissé | P. Hadwiger | Matthias J John | R. Pandey | L. Nechev | June Qin | M. Maier | E. Greene | E. Rozners | P. Pallan | Kathy Mills | Akin Akinc
[1] M. Sioud. Recent advances in small interfering RNA sensing by the immune system. , 2010, New biotechnology.
[2] Michael S. Goldberg,et al. Development of lipidoid-siRNA formulations for systemic delivery to the liver. , 2009, Molecular therapy : the journal of the American Society of Gene Therapy.
[3] I. MacRae,et al. The RNA-induced Silencing Complex: A Versatile Gene-silencing Machine* , 2009, The Journal of Biological Chemistry.
[4] R. Boisgard,et al. Molecular imaging study on in vivo distribution and pharmacokinetics of modified small interfering RNAs (siRNAs). , 2008, Oligonucleotides.
[5] W. Hagmann,et al. The many roles for fluorine in medicinal chemistry. , 2008, Journal of medicinal chemistry.
[6] Robert Langer,et al. A combinatorial library of lipid-like materials for delivery of RNAi therapeutics , 2008, Nature Biotechnology.
[7] Michael S. Goldberg,et al. Effective RNAi-mediated gene silencing without interruption of the endogenous microRNA pathway , 2007, Nature.
[8] Pirkko Muhonen,et al. RNA Interference Tolerates 2′‐Fluoro Modifications at the Argonaute2 Cleavage Site , 2007, Chemistry & biodiversity.
[9] E. Hovig,et al. Gene expression analysis in blood cells in response to unmodified and 2'-modified siRNAs reveals TLR-dependent and independent effects. , 2007, Journal of molecular biology.
[10] M. Manoharan,et al. RNAi therapeutics: a potential new class of pharmaceutical drugs , 2006, Nature chemical biology.
[11] N. Dean,et al. Competition for RISC binding predicts in vitro potency of siRNA , 2006, Nucleic acids research.
[12] M. Sioud. Single‐stranded small interfering RNA are more immunostimulatory than their double‐stranded counterparts: A central role for 2′‐hydroxyl uridines in immune responses , 2006, European journal of immunology.
[13] R. Griffey,et al. Improving RNA interference in mammalian cells by 4'-thio-modified small interfering RNA (siRNA): effect on siRNA activity and nuclease stability when used in combination with 2'-O-alkyl modifications. , 2006, Journal of medicinal chemistry.
[14] Keith Bowman,et al. Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs , 2005, Nature Biotechnology.
[15] B. Polisky,et al. Activity of stabilized short interfering RNA in a mouse model of hepatitis B virus replication , 2005, Hepatology.
[16] R. Griffey,et al. Positional effect of chemical modifications on short interference RNA activity in mammalian cells. , 2005, Journal of Medicinal Chemistry.
[17] D. Barford,et al. Structural insights into mRNA recognition from a PIWI domain–siRNA guide complex , 2005, Nature.
[18] S. Akira,et al. Sequence-specific potent induction of IFN-α by short interfering RNA in plasmacytoid dendritic cells through TLR7 , 2005, Nature Medicine.
[19] R. Griffey,et al. Fully 2'-modified oligonucleotide duplexes with improved in vitro potency and stability compared to unmodified small interfering RNA. , 2005, Journal of medicinal chemistry.
[20] M. Manoharan. RNA interference and chemically modified small interfering RNAs. , 2004, Current opinion in chemical biology.
[21] P. Connett,et al. Fluorine in medicine , 2004 .
[22] J. Dunitz. Organic Fluorine: Odd Man Out , 2004, Chembiochem : a European journal of chemical biology.
[23] Anton P. McCaffrey,et al. In vivo activity of nuclease-resistant siRNAs. , 2004, RNA.
[24] T. Rana,et al. siRNA function in RNAi: a chemical modification analysis. , 2003, RNA.
[25] David R Corey,et al. RNA interference in mammalian cells by chemically-modified RNA. , 2003, Biochemistry.
[26] Thomas Tuschl,et al. Sequence, chemical, and structural variation of small interfering RNAs and short hairpin RNAs and the effect on mammalian gene silencing. , 2003, Antisense & nucleic acid drug development.
[27] E. Westhof,et al. Hydrophobic Groups Stabilize the Hydration Shell of 2'-O-Methylated RNA Duplexes. , 2001, Angewandte Chemie.
[28] M. Teplova,et al. X-ray crystal structure of a locked nucleic acid (LNA) duplex composed of a palindromic 10-mer DNA strand containing one LNA thymine monomer , 2001 .
[29] P. D. Cook,et al. Crystal structure and improved antisense properties of 2'-O-(2-methoxyethyl)-RNA , 1999, Nature Structural Biology.
[30] N. Usman,et al. RNA hydration: a detailed look. , 1996, Biochemistry.
[31] P. D. Cook,et al. Uniformly modified 2'-deoxy-2'-fluoro phosphorothioate oligonucleotides as nuclease-resistant antisense compounds with high affinity and specificity for RNA targets. , 1993, Journal of medicinal chemistry.
[32] F. Eckstein,et al. Kinetic characterization of ribonuclease-resistant 2'-modified hammerhead ribozymes. , 1991, Science.
[33] E. Rozners,et al. Hydration of short DNA, RNA and 2'-OMe oligonucleotides determined by osmotic stressing. , 2004, Nucleic acids research.