Waking Experience Affects Sleep Need in Drosophila

Sleep is a vital, evolutionarily conserved phenomenon, whose function is unclear. Although mounting evidence supports a role for sleep in the consolidation of memories, until now, a molecular connection between sleep, plasticity, and memory formation has been difficult to demonstrate. We establish Drosophila as a model to investigate this relation and demonstrate that the intensity and/or complexity of prior social experience stably modifies sleep need and architecture. Furthermore, this experience-dependent plasticity in sleep need is subserved by the dopaminergic and adenosine 3′,5′-monophosphate signaling pathways and a particular subset of 17 long-term memory genes.

[1]  K. Siwicki,et al.  Mushroom Body Ablation Impairs Short-Term Memory and Long-Term Memory of Courtship Conditioning in Drosophila melanogaster , 1999, Neuron.

[2]  Giulio Tononi,et al.  Sleep homeostasis in Drosophila melanogaster. , 2004, Sleep.

[3]  Ann-Shyn Chiang,et al.  The staufen/pumilio Pathway Is Involved in Drosophila Long-Term Memory , 2003, Current Biology.

[4]  Karen S Ho,et al.  Drosophila melanogaster: an insect model for fundamental studies of sleep. , 2005, Methods in enzymology.

[5]  Benjamin H. White,et al.  Sleep in Drosophila is regulated by adult mushroom bodies , 2006, Nature.

[6]  P. Callaerts,et al.  Molecular and biochemical characterization of the aaNAT1 (Dat) locus in Drosophila melanogaster: differential expression of two gene products. , 1998, DNA and cell biology.

[7]  T. Tully,et al.  CREB and the formation of long-term memory , 1996, Current Opinion in Neurobiology.

[8]  M Heisenberg,et al.  Structural plasticity in the Drosophila brain , 1995, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[9]  Leslie B. Vosshall,et al.  Or83b Encodes a Broadly Expressed Odorant Receptor Essential for Drosophila Olfaction , 2004, Neuron.

[10]  Kevin P. Keegan,et al.  A dynamic role for the mushroom bodies in promoting sleep in Drosophila , 2006, Nature.

[11]  M. Heisenberg,et al.  ARE THE STRUCTURAL CHANGES IN ADULT DROSOPHILA MUSHROOM BODIES MEMORY TRACES? STUDIES ON BIOCHEMICAL LEARNING MUTANTS , 2007, Journal of neurogenetics.

[12]  J. Dubnau,et al.  Gene discovery in Drosophila: new insights for learning and memory. , 1998, Annual review of neuroscience.

[13]  Carlyle T. Smith,et al.  Sleep states and memory processes , 1995, Behavioural Brain Research.

[14]  Allan I Pack,et al.  Rest in Drosophila Is a Sleep-like State , 2000, Neuron.

[15]  Scott S. Campbell,et al.  Animal sleep: A review of sleep duration across phylogeny , 1984, Neuroscience & Biobehavioral Reviews.

[16]  F. Gage,et al.  Neural consequences of enviromental enrichment , 2000, Nature Reviews Neuroscience.

[17]  B. Dauwalder,et al.  Conditional rescue of the dunce learning/memory and female fertility defects with Drosophila or rat transgenes , 1995, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[18]  S. Ribeiro,et al.  Brain gene expression during REM sleep depends on prior waking experience. , 1999, Learning & memory.

[19]  T. Hensch,et al.  Experience-dependent slow-wave sleep development , 2003, Nature Neuroscience.

[20]  Jeffrey C. Hall,et al.  Resetting the Circadian Clock by Social Experience in Drosophila melanogaster , 2002, Science.

[21]  G. Tononi,et al.  Correlates of sleep and waking in Drosophila melanogaster. , 2000, Science.

[22]  P. Goldman-Rakic.  The cortical dopamine system: role in memory and cognition. , 1998, Advances in pharmacology.

[23]  R. Stickgold.  Sleep-dependent memory consolidation , 2005, Nature.

[24]  Axel Cleeremans,et al.  Experience-dependent changes in cerebral activation during human REM sleep , 2000, Nature Neuroscience.

[25]  T. Dobzhansky,et al.  Contributions to the genetics, taxonomy, and ecology of drosophila pseudoobscura and its relatives , 1945 .

[26]  Jay Hirsh,et al.  Targeted gene expression in Drosophila dopaminergic cells using regulatory sequences from tyrosine hydroxylase. , 2003, Journal of neurobiology.

[27]  D. Walsh,et al.  Exogenous Induction of Cerebral ß-Amyloidogenesis Is Governed by Agent and Host , 2006, Science.