The effects of monomer, crosslinker, and accelerator content on the mechanical property of seal-filling hydrogel material for building hermetic wall were analyzed through a series of single-direction compression experiments. Grey predication by GM(1,1) model was also used to analyze the persistent property of hydrogel material. The results showed that the elastic modulus and strength of seal-filling hydrogel increased, and the elastic tended to reduce with the growth of monomer and crosslinker content. In comparison, the effect of accelerator content was diametrically opposed. At the same time, staggered change of elastic modulus occurred and its demarcation point generally appeared at the point of 50% of vertical deformation value. In addition, through the testing of correlation degree, the accuracy of the grey prediction model to test the persistent stability of hydrogel material can be proved. As the concentration of hydrophilic monomer in hydrogel material increased, the stability was improved. The energy originated from explosion shock wave can be absorbed by seal-filling hydrogel through deformation.