Estimation of propagating dipole sources by EEG/MEG sensor arrays

We derive a generalized least squares (GLS) method for estimating propagating dipole sources using electroencephalography (EEG) and magnetoencephalography (MEG) sensor arrays. The dipole locations vary in time according to a parametric model, whereas their moments vary arbitrarily from one time point to another. We also derive the Cramer-Rao bound for the trajectory parameters. We then extend the above method to account for unknown spatially correlated noise.

[1]  A. Nehorai,et al.  Magnetoencephalography with diversely oriented and multicomponent sensors , 1997, IEEE Transactions on Biomedical Engineering.

[2]  K. Sekihara,et al.  Maximum-likelihood estimation of current-dipole parameters for data obtained using multichannel magnetometer , 1992, IEEE Transactions on Biomedical Engineering.

[3]  Z. Zhang,et al.  A fast method to compute surface potentials generated by dipoles within multilayer anisotropic spheres. , 1995, Physics in medicine and biology.

[4]  Calyampudi R. Rao,et al.  Linear statistical inference and its applications , 1965 .

[5]  R. Ilmoniemi,et al.  Magnetoencephalography-theory, instrumentation, and applications to noninvasive studies of the working human brain , 1993 .

[6]  Ehud Weinstein,et al.  Parameter estimation of superimposed signals using the EM algorithm , 1988, IEEE Trans. Acoust. Speech Signal Process..

[7]  Theo Gasser,et al.  Amplitude Probability Distribution of Noise for Flash-Evoked Potentials and Robust Response Estimates , 1986, IEEE Transactions on Biomedical Engineering.

[8]  B. Lütkenhöner Dipole source localization by means of maximum likelihood estimation. II. Experimental evaluation. , 1998, Electroencephalography and clinical neurophysiology.

[9]  B. Lutkenhoner Dipole source localization by means of maximum likelihood estimation. II. Experimental evaluation , 1998 .

[10]  M. E. Spencer,et al.  Error bounds for EEG and MEG dipole source localization. , 1993, Electroencephalography and clinical neurophysiology.

[11]  V Diekmann,et al.  Localisation of epileptic foci with electric, magnetic and combined electromagnetic models. , 1998, Electroencephalography and clinical neurophysiology.

[12]  B. Lutkenhoner,et al.  Dipole source localization by means of maximum likelihood estimation I. Theory and simulations. , 1998 .

[13]  G. B. Anderson,et al.  Modeling the Stationarity and Gaussianity of Spontaneous Electroencephalographic Activity , 1975, IEEE Transactions on Biomedical Engineering.

[14]  J. Ebersole Defining epileptogenic foci: past, present, future. , 1997, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[15]  Benjamin Friedlander,et al.  On the performance of direction finding with time-varying arrays , 1995, Signal Process..

[16]  M. Scherg,et al.  Two bilateral sources of the late AEP as identified by a spatio-temporal dipole model. , 1985, Electroencephalography and clinical neurophysiology.

[17]  Petre Stoica,et al.  MUSIC, maximum likelihood and Cramer-Rao bound: further results and comparisons , 1989, International Conference on Acoustics, Speech, and Signal Processing,.