A wide linear range surface plasmon resonance biosensor

A new surface plasmon resonance (SPR) sensor based on polarization interferometry and angle modulation is presented. Its feature is that it can provide the same sensitivity in a wide refractive index (RI) range. Moreover, the sensitivity ofthis SPR sensor is insensitive to the thickness of gold films over about 5 mu. Experimental results show that its resolution in an integration time of 0.5 second is 1.7 × 10-7 refractive index units (RIU). It demonstrates great potential to be commercialized and widely applied in biological research.