Antidiuretic effect of antimuscarinic agents in rat model depends on C‐fibre afferent nerves in the bladder

Antichollnergic agents are anticipated to diminish storage symptoms, as well as nocturia. Nevertheless, the effect of this treatment on polyuria related to nocturia is not clear. By subgroup analysis of the data set from a phase III clinical trial of antimuscarinic agent for OAB patients in Japan, imidafenacin was found to improve nocturia with a reduction in nocturnal polyuria. This study adds the effects and underlying mechanism of antimuscarinic agents decreasing urine production through inhibition of C‐fibre in the bladder of water‐leaded rats.

[1]  H. Kakizaki,et al.  Effect of Imidafenacin on Nocturia and Sleep Disorder in Patients with Overactive Bladder , 2012, Urologia Internationalis.

[2]  H. Kakizaki,et al.  Efficacy of solifenacin on nocturia in Japanese patients with overactive bladder: impact on sleep evaluated by bladder diary. , 2011, The Journal of urology.

[3]  M. Namiki,et al.  α1-Adrenoceptor blocker naftopidil improves sleep disturbance with reduction in nocturnal urine volume , 2011, World Journal of Urology.

[4]  Y. Homma,et al.  Antimuscarinic agent improves nocturia with reduction in nocturnal urine volume , 2010 .

[5]  R. Chess-Williams,et al.  The inhibitory role of acetylcholine and muscarinic receptors in bladder afferent activity. , 2010, European urology.

[6]  H. Akino,et al.  Melatonin increases bladder capacity via GABAergic system and decreases urine volume in rats. , 2010, The Journal of urology.

[7]  Alex Wang,et al.  Nocturia , 2010, Obstetrical & gynecological survey.

[8]  H. Akino,et al.  Improvement in neurogenic detrusor overactivity by peripheral C fiber's suppression with cyclooxygenase inhibitors. , 2010, The Journal of urology.

[9]  Y. Homma,et al.  A randomized, double‐blind, placebo‐controlled phase II dose‐finding study of the novel anti‐muscarinic agent imidafenacin in Japanese patients with overactive bladder , 2008, International journal of urology : official journal of the Japanese Urological Association.

[10]  O. Ukimura,et al.  Efficacy of a novel device for assessment of autonomic sensory function in the rat bladder. , 2008, The Journal of urology.

[11]  L. Brubaker,et al.  Nocturnal polyuria and nocturia relief in patients treated with solifenacin for overactive bladder symptoms , 2007, International Urogynecology Journal.

[12]  R. Dmochowski,et al.  Efficacy and tolerability of tolterodine extended‐release in continent patients with overactive bladder and nocturia , 2006, BJU international.

[13]  J. Weiss,et al.  Nighttime dosing with tolterodine reduces overactive bladder-related nocturnal micturitions in patients with overactive bladder and nocturia. , 2006, Urology.

[14]  N. Oyama,et al.  Improvement of bladder storage function by α1‐blocker depends on the suppression of C‐fiber afferent activity in rats , 2006, Neurourology and urodynamics.

[15]  N. Oyama,et al.  Effects of tolterodine on an overactive bladder depend on suppression of C-fiber bladder afferent activity in rats. , 2005, The Journal of urology.

[16]  A. Meli,et al.  Capsaicin-sensitive afferents in the rat urinary bladder activate a spinal sympathetic cardiovascular reflex , 1988, Naunyn-Schmiedeberg's Archives of Pharmacology.

[17]  Y. Igawa,et al.  The role of capsaicin‐sensitive afferents in autonomic dysreflexia in patients with spinal cord injury , 2003, BJU international.

[18]  Poul Jennum,et al.  The standardisation of terminology in nocturia: Report from the standardisation sub‐committee of the International Continence Society , 2002, Neurourology and urodynamics.

[19]  Magnus Fall,et al.  The standardisation of terminology in lower urinary tract function: report from the standardisation sub-committee of the International Continence Society. , 2003, Urology.

[20]  A. Wein,et al.  Tolterodine once-daily: superior efficacy and tolerability in the treatment of the overactive bladder. , 2001, Urology.

[21]  Y. Yoshimura,et al.  Gender specificity of tolterodine on micturition and the diurnal variation of urine production of the conscious rat , 2000, BJU international.

[22]  J. Blaivas,et al.  CLINICAL UROLOGY: Review ArticleNOCTURIA , 2000 .

[23]  W. D. de Groat,et al.  Influence of anesthesia on bladder hyperactivity induced by middle cerebral artery occlusion in the rat. , 1997, The American journal of physiology.

[24]  H. Kamphuisen,et al.  Subjective sleep characteristics of 1,485 males and females aged 50-93: effects of sex and age, and factors related to self-evaluated quality of sleep. , 1996, The journals of gerontology. Series A, Biological sciences and medical sciences.

[25]  R. Asplund.  The nocturnal polyuria syndrome (NPS). , 1995, General pharmacology.

[26]  W. C. Groat,et al.  Effects of capsaicin on micturition and associated reflexes in rats. , 1993, The American journal of physiology.