The structure and ligand interactions of CD2: implications for T-cell function.

Abstract Considerable progress has recently been made in understanding the structure and ligand interactions of the T-cell antigen CD2, to the extent that CD2 is now a useful paradigm for considering the structural basis of cell-cell recognition. Here, Simon Davis and Anton van der Merwe review the new data and consider their implications for T-cell function in the context of CD2-knockout experiments.

[1]  G. Wagner,et al.  Composition and sequence specific resonance assignments of the heterogeneous N-linked glycan in the 13.6 kDa adhesion domain of human CD2 as determined by NMR on the intact glycoprotein. , 1995, Biochemistry.

[2]  M. Horton,et al.  The Leucocyte Antigen Factsbook , 1993 .

[3]  D. Stuart,et al.  Crystal structure of the extracellular region of the human cell adhesion molecule CD2 at 2.5 A resolution. , 1994, Structure.

[4]  A. F. Williams,et al.  The immunoglobulin superfamily--domains for cell surface recognition. , 1988, Annual review of immunology.

[5]  Y. Shimizu,et al.  A role for phosphatidylinositol 3-kinase in the regulation of beta 1 integrin activity by the CD2 antigen , 1995, The Journal of cell biology.

[6]  M. Kuroki,et al.  A specific heterotypic cell adhesion activity between members of carcinoembryonic antigen family, W272 and NCA, is mediated by N-domains. , 1991, The Journal of biological chemistry.

[7]  A. Barclay,et al.  Transient intercellular adhesion: the importance of weak protein-protein interactions. , 1994, Trends in biochemical sciences.

[8]  J. Trapani,et al.  Isolation and characterization of cDNA clones for mouse Ly-9. , 1992, Journal of immunology.

[9]  E. Reinherz,et al.  An alternative pathway of T-cell activation: A functional role for the 50 kd T11 sheep erythrocyte receptor protein , 1984, Cell.

[10]  Alan F. Williams,et al.  At grips with interactions , 1992, Nature.

[11]  Paul M. Allen,et al.  Partial T cell signaling: Altered phospho-ζ and lack of zap70 recruitment in APL-induced T cell anergy , 1994, Cell.

[12]  A. Williams,et al.  Multimolecular associations of the T-cell antigen receptor. , 1992, Trends in cell biology.

[13]  G. I. Bell.  Models for the specific adhesion of cells to cells. , 1978, Science.

[14]  Dan R. Littman,et al.  Signal transduction by lymphocyte antigen receptors , 1994, Cell.

[15]  M. Schilham,et al.  Equivalence of human and mouse CD4 in enhancing antigen responses by a mouse class II-restricted T cell hybridoma , 1989, The Journal of experimental medicine.

[16]  C. Janeway,et al.  Ligands for the T-cell receptor: hard times for avidity models. , 1995, Immunology today.

[17]  T. Watanabe,et al.  Long-term survival of cardiac allografts in rats treated before and after surgery with monoclonal antibody to CD2. , 1995, Transplantation.

[18]  B. Reinhold,et al.  N-glycosylation is required for human CD2 immunoadhesion functions. , 1992, The Journal of biological chemistry.

[19]  M. Taniguchi,et al.  Induction of negative signal through CD2 during antigen-specific T cell activation. , 1991, Journal of immunology.

[20]  D. Mason,et al.  Human cell-adhesion molecule CD2 binds CD58 (LFA-3) with a very low affinity and an extremely fast dissociation rate but does not bind CD48 or CD59. , 1994, Biochemistry.

[21]  B. Seed.  An LFA-3 cDNA encodes a phospholipid-linked membrane protein homologous to its receptor CD2 , 1987, Nature.

[22]  Timothy A. Springer,et al.  Adhesion receptors of the immune system , 1990, Nature.

[23]  F. Grunert,et al.  Carcinoembryonic antigen gene family: Molecular biology and clinical perspectives , 1991, Journal of clinical laboratory analysis.

[24]  Michael Loran Dustin,et al.  Influence of receptor lateral mobility on adhesion strengthening between membranes containing LFA-3 and CD2 , 1991, The Journal of cell biology.

[25]  M. Bevan,et al.  T cell receptor antagonists and partial agonists. , 1995, Immunity.

[26]  S. Ratnofsky,et al.  The biologic roles of CD2, CD4, and CD8 in T-cell activation. , 1989, Annual review of immunology.

[27]  Michael Loran Dustin,et al.  Anchoring mechanisms for LFA-3 cell adhesion glycoprotein at membrane surface , 1987, Nature.

[28]  A. F. Williams,et al.  A year in the life of the immunoglobulin superfamily. , 1987, Immunology today.

[29]  C. Heldin,et al.  Dimerization of cell surface receptors in signal transduction , 1995, Cell.

[30]  K. Kato,et al.  CD48 is a counter-receptor for mouse CD2 and is involved in T cell activation , 1992, The Journal of experimental medicine.

[31]  W. Decock,et al.  Suppression of human T-cell mitogenesis and E-rosette formation by the monoclonal antibody OKT11A. , 1981, Immunology.

[32]  D. Littman,et al.  Development and function of T cells in mice with a disrupted CD2 gene. , 1992, The EMBO journal.

[33]  J. Cyster,et al.  Mutational analysis of the CD2/CD58 interaction: the binding site for CD58 lies on one face of the first domain of human CD2 , 1993, The Journal of experimental medicine.

[34]  R. Mariuzza,et al.  Crystal structure of the beta chain of a T cell antigen receptor. , 1995, Science.

[35]  A. Lanzavecchia,et al.  Serial triggering of many T-cell receptors by a few peptide–MHC complexes , 1995, Nature.

[36]  S. Kingsmore,et al.  Structure, expression, and genetic linkage of the mouse BCM1 (OX45 or Blast-1) antigen. Evidence for genetic duplication giving rise to the BCM1 region on mouse chromosome 1 and the CD2/LFA3 region on mouse chromosome 3 , 1990, The Journal of experimental medicine.

[37]  M. Smith,et al.  Cellular expression of lymphocyte function associated antigens and the intercellular adhesion molecule-1 in normal tissue. , 1990, Journal of clinical pathology.

[38]  J. Lawrence,et al.  Blast-1 possesses a glycosyl-phosphatidylinositol (GPI) membrane anchor, is related to LFA-3 and OX-45, and maps to chromosome 1q21-23 , 1989, The Journal of experimental medicine.

[39]  E. Reinherz,et al.  Structure of the glycosylated adhesion domain of human T lymphocyte glycoprotein CD2. , 1993, Structure.

[40]  A. Lanzavecchia,et al.  Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton , 1995, The Journal of experimental medicine.

[41]  B. Honig,et al.  Classical electrostatics in biology and chemistry. , 1995, Science.

[42]  David I. Stuart,et al.  Crystal structure at 2.8 Å resolution of a soluble form of the cell adhesion molecule CD2 , 1992, Nature.

[43]  Michael Loran Dustin,et al.  The T lymphocyte glycoprotein CD2 binds the cell surface ligand LFA-3 , 1987, Nature.

[44]  A. Barclay,et al.  A role in transmembrane signaling for the cytoplasmic domain of the CD2 T lymphocyte surface antigen , 1988, Cell.

[45]  P. Marrack,et al.  A little of what you fancy . . . , 1994, Nature.

[46]  M. Deckert,et al.  CD59 molecule: A second ligand for CD2 in T cell adhesion , 1992, European journal of immunology.

[47]  T. Hünig.  Ident i f icat ion and Partial Character izat ion Using a Monoclonal An t ibody , 2003 .

[48]  B. Cocks,et al.  A novel receptor involved in T-cell activation , 1995, Nature.

[49]  M. Bennett,et al.  Cloning and characterization of the 2B4 gene encoding a molecule associated with non-MHC-restricted killing mediated by activated natural killer cells and T cells. , 1993, Journal of immunology.

[50]  M. Glennie,et al.  Signal transduction by the CD2 antigen in T cells and natural killer cells: requirement for expression of a functional T cell receptor or binding of antibody Fc to the Fc receptor, Fc gamma RIIIA (CD16) , 1991, The Journal of experimental medicine.

[51]  D. Leckband,et al.  Molecular mechanisms determining the strength of receptor-mediated intermembrane adhesion. , 1995, Biophysical journal.

[52]  P. Altevogt,et al.  Anti-CD2 antibodies induce T cell unresponsiveness in vivo , 1991, The Journal of experimental medicine.

[53]  A. Barclay,et al.  A sensitive assay for detecting low‐affinity interactions at the cell surface reveals no additional ligands for the adhesion pair rat CD2 and CD48 , 1995, European journal of immunology.

[54]  T. Mustelin.  T cell antigen receptor signaling: three families of tyrosine kinases and a phosphatase. , 1994, Immunity.

[55]  J. Bromberg,et al.  Anti-CD2 receptor and anti-CD2 ligand (CD48) antibodies synergize to prolong allograft survival , 1994, The Journal of experimental medicine.

[56]  A. Barclay,et al.  Activation of T Lymphocytes via Monoclonal Antibodies against Rat Cell Surface Antigens with Particular Reference to CD2 Antigen , 1989, Immunological reviews.

[57]  E. Reinherz,et al.  The Structural Biology of CD2 , 1989, Immunological reviews.

[58]  D. Paterson,et al.  Similarities in sequences and cellular expression between rat CD2 and CD4 antigens , 1987, The Journal of experimental medicine.

[59]  K. Rajewsky,et al.  A role for CD5 in TCR-mediated signal transduction and thymocyte selection. , 1995, Science.

[60]  N. Killeen,et al.  The MRC OX‐45 antigen of rat leukocytes and endothelium is in a subset of the immunoglobulin superfamily with CD2, LFA‐3 and carcinoembryonic antigens. , 1988, The EMBO journal.

[61]  E. Reinherz,et al.  A soluble multimeric recombinant CD2 protein identifies CD48 as a low affinity ligand for human CD2: divergence of CD2 ligands during the evolution of humans and mice , 1993, The Journal of experimental medicine.

[62]  L. Sherman,et al.  Selecting T cell receptors with high affinity for self-MHC by decreasing the contribution of CD8. , 1992, Science.

[63]  E. Reinherz,et al.  Structural and functional characterization of the CD2 immunoadhesion domain. Evidence for inclusion of CD2 in an alpha-beta protein folding class. , 1990, The Journal of biological chemistry.

[64]  S. Tonegawa,et al.  A differential-avidity model for T-cell selection. , 1994, Immunology today.

[65]  W. Hahn,et al.  Separable portions of the CD2 cytoplasmic domain involved in signaling and ligand avidity regulation , 1993, The Journal of experimental medicine.

[66]  Peter D. Kwong,et al.  Structural basis of cell-cell adhesion by cadherins , 1995, Nature.

[67]  S Chien,et al.  Micromanipulation of adhesion of a Jurkat cell to a planar bilayer membrane containing lymphocyte function-associated antigen 3 molecules , 1992, The Journal of cell biology.

[68]  B. Seed,et al.  Monoclonal antibody and ligand binding sites of the T cell erythrocyte receptor (CD2) , 1987, Nature.

[69]  O. Lantz,et al.  Apoptosis of activated CD8+/CD57+ T cells is induced by some combinations of anti-CD2 mAb. , 1993, Journal of immunology.

[70]  Michael Loran Dustin,et al.  The lymphocyte function-associated LFA-1, CD2, and LFA-3 molecules: cell adhesion receptors of the immune system. , 1987, Annual review of immunology.

[71]  P. Anton van der Merwe,et al.  Topology of the CD2–CD48 cell-adhesion molecule complex: implications for antigen recognition by T cells , 1995, Current Biology.

[72]  A Leung,et al.  Detachment of agglutinin-bonded red blood cells. I. Forces to rupture molecular-point attachments. , 1991, Biophysical journal.

[73]  D. Baltimore,et al.  Modular binding domains in signal transduction proteins , 1995, Cell.

[74]  A. Barclay,et al.  Affinity and kinetic analysis of the interaction of the cell adhesion molecules rat CD2 and CD48. , 1993, The EMBO journal.

[75]  J Li,et al.  Conformation and function of the N-linked glycan in the adhesion domain of human CD2 , 1995, Science.

[76]  I. Campbell,et al.  Structure of domain 1 of rat T lymphocyte CD2 antigen , 1991, Nature.

[77]  J. Gribben,et al.  Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7 , 1991, The Journal of experimental medicine.

[78]  Kazunori Kato,et al.  Identification of the T cell surface signal‐transducing glycoprotein sgp‐60 as CD48, a counter‐receptor for mouse CD2 , 1993, European journal of immunology.

[79]  H. Hauser,et al.  Preferred conformation and molecular packing of phosphatidylethanolamine and phosphatidylcholine. , 1981, Biochimica et biophysica acta.

[80]  P. Altevogt,et al.  Association of CD2 and CD45 on human T lymphocytes , 1990, Nature.

[81]  W. Hahn,et al.  Overlapping but nonidentical binding sites on CD2 for CD58 and a second ligand CD59. , 1992, Science.

[82]  E. Reinherz,et al.  Structural and binding analysis of a two domain extracellular CD2 molecule , 1989, The Journal of experimental medicine.

[83]  K. Rajewsky,et al.  Lymphocyte populations and immune responses in CD5‐deficient mice , 1994, European journal of immunology.

[84]  C. Chothia,et al.  The structure of protein-protein recognition sites. , 1990, The Journal of biological chemistry.

[85]  D. Stuart,et al.  Expression cloning of an equine T-lymphocyte glycoprotein CD2 cDNA. Structure-based analysis of conserved sequence elements. , 1994, European journal of biochemistry.

[86]  P. Kraulis.  A program to produce both detailed and schematic plots of protein structures , 1991 .

[87]  M. McGregor,et al.  Interaction between human CD2 and CD58 involves the major beta sheet surface of each of their respective adhesion domains , 1994, The Journal of experimental medicine.

[88]  M. Ferguson,et al.  Cell-surface anchoring of proteins via glycosyl-phosphatidylinositol structures. , 1988, Annual review of biochemistry.

[89]  J. Cyster,et al.  The NH2‐terminal domain of rat CD2 binds rat CD48 with a low affinity and binding does not require glycosylation of CD2 , 1993, European journal of immunology.

[90]  D. Bodian,et al.  Analysis of the structure and interactions of CD2. , 1993, Biochemical Society transactions.

[91]  Michael Loran Dustin,et al.  Primary structure of lymphocyte function-associated antigen 3 (LFA-3). The ligand of the T lymphocyte CD2 glycoprotein , 1987, The Journal of experimental medicine.

[92]  B. Bierer,et al.  Synergistic T cell activation via the physiological ligands for CD2 and the T cell receptor , 1988, The Journal of experimental medicine.

[93]  D I Stuart,et al.  Ligand Binding by the Immunoglobulin Superfamily Recognition Molecule CD2 Is Glycosylation-independent (*) , 1995, The Journal of Biological Chemistry.

[94]  D. Mason,et al.  Physical association of the cytoplasmic domain of CD2 with the tyrosine kinases p56lck and p59fyn , 1993, European journal of immunology.