Ascorbic acid 및 citric acid 처리에 따른 홍삼추출물의 페놀성 성분 및 ginsenoside 함량 변화

The changes that would occur in a content of five phenolic ingredients and eight ginsenosides in acid-treatedred ginseng extracts were measured in this study. Acid-treated-red ginseng was prepared by treating with 1 M ascorbic acid or citric acid for 20 min. As a result, the contents of esculetin and quercetin in citric acid-treated-red ginseng increased by 3.5 times and 2.0 times, respectively, compared with control red ginseng. However, all phenolic ingredients decreased after treatment with ascorbic acid. In addition, the contents of ginsenoside Rg₃, Rh₂, Rd increased but those of Rb1, Rc, Re, Rf, Rg₁ decreased after acid treatment. Although these tendency of results are similar, the rate of change of ginsenosides in citric acid-treated-red ginseng was higher than in ascorbic acid-treated-red ginseng. These results indicated that citric acid is more effective in the conversion of ginseng ingredients than ascorbic acid.

[1]  이영철,et al.  백삼과 홍삼의 페놀성 성분 함량 및 멜라닌 생성억제효과 , 2006 .

[2]  박종대,et al.  홍삼산성다당체 (RGAP)의 경구투여에 의한 항종양 효과 , 2005 .

[3]  I. Nagata,et al.  Inhibitory effects by oral administration of ginsenoside Rh2 on the growth of human ovarian cancer cells in nude mice , 2005, Journal of Cancer Research and Clinical Oncology.

[4]  김동훈,et al.  반복 스트레스에 의한 흰주 해마조직내 신경전구세포의 생성과 brain-derived neurotrophic factor (BDNF) mRNA 발현 변동에 미치는 고려홍삼 사포닌의 반복 투여 효과 , 2004 .

[5]  Sung-Woo Lee,et al.  Antioxidant Activities of Leaf, Stem and Root of Panax ginseng C. A. Meyer , 2004 .

[6]  Myeon Choe,et al.  Synergistic Effects of extracts from korean red ginseng, saururus chinensis(Lour) Baill. And Rubus coreanus Miq on Antioxidative activities in rats , 2003 .

[7]  박채규,et al.  Changes in Chemical Components of Red Ginseng Processed from the Fresh Ginseng Stored at Low Temperature , 2003 .

[8]  S. Kitagawa,et al.  Characterization of ginseng saponin ginsenoside-Rg(3) inhibition of catecholamine secretion in bovine adrenal chromaffin cells. , 2001, Biochemical pharmacology.

[9]  Yun‐Sil Lee,et al.  Cancer Chemopreventive Compounds of Red Ginseng Produced from Panax ginseng C.A. Meyer , 2001 .

[10]  J. H. Park,et al.  Antioxidant and anti-tumor promoting activities of the methanol extract of heat-processed ginseng. , 2000, Cancer letters.

[11]  전병화,et al.  신성고혈압백서에서 혈압에 미치는 고려홍삼사포닌과 비사포닌의 효과 ( Effect of Saponin and Non-saponin of Panax Ginseng on the Blood Pressure in the Renovascular Hypertensive Rats ) , 1999 .

[12]  Seong-kyun Lee,et al.  Property and Inhibition of the Hydrolysis of Ginseng Saponins by Organic Acids Neutralization in Ginseng Extract Preparations , 1998 .

[13]  Y. Oh,et al.  Activation of caspase-3 protease via a Bcl-2-insensitive pathway during the process of ginsenoside Rh2-induced apoptosis. , 1997, Cancer letters.

[14]  D. Rhee,et al.  Effects of ginseng saponin on modulation of multidrug resistance , 1996 .

[15]  이정희,et al.  옥수수기름 및 우지 식이에 의한 혈소판 응집 반응과 혈액응고에 있어서 홍삼 지용성성분이 미치는 영향 ( Effects of Lipophilic Fraction from Korean Red Ginseng on Platelet Aggregation and Blood Coagulation in Rats Fed with Corn Oil and Beeftallow Diet ) , 1995 .

[16]  Y. Yoo,et al.  Inhibitory effect of tumor metastasis in mice by saponins, ginsenoside-Rb2, 20(R)- and 20(S)-ginsenoside-Rg3, of red ginseng. , 1995, Biological & pharmaceutical bulletin.

[17]  S Odashima,et al.  Mechanism of action of ginsenoside Rh2: uptake and metabolism of ginsenoside Rh2 by cultured B16 melanoma cells. , 1991, Journal of pharmaceutical sciences.

[18]  I. Nagata,et al.  Inhibition of human ovarian cancer cell proliferation in vitro by ginsenoside Rh2 and adjuvant effects to cisplatin in vivo , 1991, Anti-cancer drugs.

[19]  S. Zhang,et al.  A New Minor Saponin from the Leaves of Panax ginseng. , 1990, Planta medica.

[20]  I. Kitagawa,et al.  Chemical Studies on Crude Drug Processing. VI. : Chemical Structures of Malonyl-ginsenosides Rb1, Rb2, Rc, and Rd Isolated from the Root of Panax ginseng C. A. MEYER , 1989 .

[21]  S. Yahara,et al.  Degradation of ginseng saponins under mild acidic conditions. , 1982, Planta medica.

[22]  M. Nagai,et al.  STUDIES ON THE CONSTITUENTS OF JAPANESE AND CHINESE CRUDE DRUGS. XII. PANAXADIOL, A SAPOGENIN OF GINSENG ROOTS. , 1963, Chemical & pharmaceutical bulletin.