Genome-wide Association Study of Pediatric Obsessive-Compulsive Traits: Shared Genetic Risk between Traits and Disorder

Dan J Stein | Ben D. Greenberg | R. Delorme | M. Leboyer | E. Cook | A. Paterson | S. Rauch | M. Turiel | B. Neale | H. Nicolini | M. Jenike | P. Falkai | D. Rosenberg | A. Fyer | D. Conti | J. Knowles | C. Pittenger | D. Posthuma | Y. Shugart | J. McCracken | E. Derks | S. Rasmussen | D. Denys | M. Mattheisen | J. Veenstra-VanderWeele | Dongmei Yu | J. Scharf | L. Davis | S. Ripke | F. Macciardi | S. Walitza | G. Hanna | G. Nestadt | O. Bienvenu | M. Riddle | B. Maher | Ying Wang | M. Grados | F. Goes | B. Cullen | J. Samuels | E. Grünblatt | J. Wendland | M. Bloch | J. Bralten | N. Lanzagorta | L. Strug | M. Cavallini | J. Smit | C. Barlassina | A. Pulver | K. Liang | M. Lemire | C. Burton | R. Schachar | E. Khramtsova | P. Arnold | K. Fitzgerald | C. Lochner | E. Nurmi | J. Piacentini | S. Stewart | C. Mathews | D. Cath | N. Vulink | S. Ruhrmann | Wei Guo | G. Poelmans | C. Cappi | A. Sampaio | H. Brentani | E. Miguel | A. Hounie | L. Osiecki | C. Edlund | M. Richter | B. Camarena | V. Coric | V. Eapen | D. Cusi | Clare L Keenan | D. Geller | N. McLaughlin | K. Askland | C. Lange | L. Erdman | J. Krasnow | P. Nestadt | G. Zai | V. Ciullo | J. Crosbie | H. Vallada | N. McGregor | Clare L. Keenan | S. Shaheen | M. Wagner | T. Goodale | E. Corfield | V. M. Sinopoli | B. Xiao | H. Grabe | James L. Kennedy | D. Black | N. Soreni | Kathleen D. Cristina O. Joseph Donald Michael Helena Beatri Askland Barlassina Bienvenu Black Bloch | B. D. Greenberg | Andrew D. Paterson | Kate D. Fitzgerald | Gregory L. Hanna | Lauren Erdman | Paul D. Arnold | Elizabeth C. Corfield | David R. Rosenberg | Lisa Strug

[1]  D. Smit,et al.  Genetic meta‐analysis of obsessive–compulsive disorder and self‐report compulsive symptoms , 2019, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[2]  D. Smit,et al.  Genetic meta‐analysis of obsessive–compulsive disorder and self‐report compulsive symptoms , 2019, bioRxiv.

[3]  Paul J. Harrison,et al.  The genomic basis of mood instability: identification of 46 loci in 363,705 UK Biobank participants, genetic correlation with psychiatric disorders, and association with gene expression and function , 2019, bioRxiv.

[4]  J. Rommens,et al.  Genetic association and transcriptome integration identify contributing genes and tissues at cystic fibrosis modifier loci , 2019, PLoS genetics.

[5]  Alicia R. Martin,et al.  Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder , 2018, Nature Genetics.

[6]  C. Burton,et al.  Heritability of obsessive–compulsive trait dimensions in youth from the general population , 2018, Translational Psychiatry.

[7]  Dan J Stein,et al.  Revealing the complex genetic architecture of obsessive–compulsive disorder using meta-analysis , 2018, Molecular Psychiatry.

[8]  D. Posthuma,et al.  Functional mapping and annotation of genetic associations with FUMA , 2017, Nature Communications.

[9]  Stephen H. Bell,et al.  Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry , 2022 .

[10]  Y. Kawasaki,et al.  Spatial and temporal expression patterns of genes around nine neuroticism-associated loci , 2017, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[11]  J. Pell,et al.  M7 GENOME-WIDE ANALYSIS IN UK BIOBANK IDENTIFIES FOUR LOCI ASSOCIATED WITH MOOD INSTABILITY AND GENETIC CORRELATION WITH MDD, ANXIETY DISORDER AND SCHIZOPHRENIA , 2019, European Neuropsychopharmacology.

[12]  Jakob Grove,et al.  Discovery of the first genome-wide significant risk loci for ADHD , 2017, bioRxiv.

[13]  A. Bhardwaj,et al.  In situ click chemistry generation of cyclooxygenase-2 inhibitors , 2017, Nature Communications.

[14]  S. Scherer,et al.  Uncovering obsessive-compulsive disorder risk genes in a pediatric cohort by high-resolution analysis of copy number variation , 2016, Journal of Neurodevelopmental Disorders.

[15]  David M. Evans,et al.  A Genome-Wide Association Meta-Analysis of Attention-Deficit/Hyperactivity Disorder Symptoms in Population-Based Pediatric Cohorts. , 2016, Journal of the American Academy of Child and Adolescent Psychiatry.

[16]  B. Pasaniuc,et al.  Contrasting the genetic architecture of 30 complex traits from summary association data , 2016, bioRxiv.

[17]  A. Hofmann,et al.  Array-based molecular karyotyping in fetuses with isolated brain malformations identifies disease-causing CNVs , 2016, Journal of Neurodevelopmental Disorders.

[18]  E. Storch,et al.  The Toronto Obsessive-Compulsive Scale: Psychometrics of a Dimensional Measure of Obsessive-Compulsive Traits. , 2016, Journal of the American Academy of Child and Adolescent Psychiatry.

[19]  N. Kato,et al.  Genome‐wide Association Study of Autism Spectrum Disorder in the East Asian Populations , 2016, Autism research : official journal of the International Society for Autism Research.

[20]  D. Smit,et al.  Obsessive–compulsive symptoms in a large population-based twin-family sample are predicted by clinically based polygenic scores and by genome-wide SNPs , 2016, Translational Psychiatry.

[21]  Michael F. Green,et al.  Genetic assessment of additional endophenotypes from the Consortium on the Genetics of Schizophrenia Family Study , 2016, Schizophrenia Research.

[22]  Kosha Ruparel,et al.  The Philadelphia Neurodevelopmental Cohort: constructing a deep phenotyping collaborative. , 2015, Journal of child psychology and psychiatry, and allied disciplines.

[23]  S. Zhao,et al.  Developmental expression and function analysis of protein tyrosine phosphatase receptor type D in oligodendrocyte myelination , 2015, Neuroscience.

[24]  P. Visscher,et al.  Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores , 2015, bioRxiv.

[25]  Jakob Grove,et al.  Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population , 2015, Nature Genetics.

[26]  S. Fukai,et al.  Structure of Slitrk2–PTPδ complex reveals mechanisms for splicing-dependent trans-synaptic adhesion , 2015, Scientific Reports.

[27]  M. Daly,et al.  An Atlas of Genetic Correlations across Human Diseases and Traits , 2015, Nature Genetics.

[28]  Joris M. Mooij,et al.  MAGMA: Generalized Gene-Set Analysis of GWAS Data , 2015, PLoS Comput. Biol..

[29]  John Wei,et al.  Copy number variation in Han Chinese individuals with autism spectrum disorder , 2014, Journal of Neurodevelopmental Disorders.

[30]  Scott L. Rauch,et al.  Obsessive–compulsive Disorder (ocd) , 2022 .

[31]  S. E. Stewart,et al.  Genome-Wide Association Study in Obsessive-Compulsive Disorder: Results from the OCGAS , 2014, Molecular Psychiatry.

[32]  M. Daly,et al.  LD Score regression distinguishes confounding from polygenicity in genome-wide association studies , 2014, Nature Genetics.

[33]  Benjamin D. Greenberg,et al.  Partitioning the Heritability of Tourette Syndrome and Obsessive Compulsive Disorder Reveals Differences in Genetic Architecture , 2013, PLoS genetics.

[34]  Ann Marie Craig,et al.  Protein tyrosine phosphatases PTPδ, PTPσ, and LAR: presynaptic hubs for synapse organization , 2013, Trends in Neurosciences.

[35]  Seungtai Yoon,et al.  Characterization of SLITRK1 Variation in Obsessive-Compulsive Disorder , 2013, PloS one.

[36]  Y Wang,et al.  Genome-wide association study of obsessive-compulsive disorder , 2013, Molecular Psychiatry.

[37]  S. E. Stewart,et al.  Meta‐analysis of association between obsessive‐compulsive disorder and the 3′ region of neuronal glutamate transporter gene SLC1A1 , 2013, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[38]  Ellen T. Gelfand,et al.  The Genotype-Tissue Expression (GTEx) project , 2013, Nature Genetics.

[39]  J. Swanson,et al.  Response Inhibition and ADHD Traits: Correlates and Heritability in a Community Sample , 2013, Journal of abnormal child psychology.

[40]  M. Bloch,et al.  Systematic Review of Proinflammatory Cytokines in Obsessive-Compulsive Disorder , 2012, Current Psychiatry Reports.

[41]  Michael R Knowles,et al.  Multiple apical plasma membrane constituents are associated with susceptibility to meconium ileus in individuals with cystic fibrosis , 2012, Nature Genetics.

[42]  M. Mishina,et al.  Interleukin-1 Receptor Accessory Protein Organizes Neuronal Synaptogenesis as a Cell Adhesion Molecule , 2012, The Journal of Neuroscience.

[43]  Jia-Jia Liu,et al.  Retrolinkin cooperates with endophilin A1 to mediate BDNF–TrkB early endocytic trafficking and signaling from early endosomes , 2011, Molecular biology of the cell.

[44]  M. Mishina,et al.  IL-1 Receptor Accessory Protein-Like 1 Associated with Mental Retardation and Autism Mediates Synapse Formation by Trans-Synaptic Interaction with Protein Tyrosine Phosphatase δ , 2011, The Journal of Neuroscience.

[45]  F. Rijsdijk,et al.  A multivariate twin study of obsessive-compulsive symptom dimensions. , 2011, Archives of general psychiatry.

[46]  B. Browning,et al.  A fast, powerful method for detecting identity by descent. , 2011, American journal of human genetics.

[47]  P. Visscher,et al.  GCTA: a tool for genome-wide complex trait analysis. , 2011, American journal of human genetics.

[48]  Shahin Rafii,et al.  Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive–like behaviors in mice , 2010, Nature Medicine.

[49]  E. Herzog,et al.  Circadian Modulation of Gene Expression, but not Glutamate Uptake, in Mouse and Rat Cortical Astrocytes , 2009, PloS one.

[50]  Joseph T. Glessner,et al.  Rare structural variants found in attention-deficit hyperactivity disorder are preferentially associated with neurodevelopmental genes , 2009, Molecular Psychiatry.

[51]  C. Pittenger,et al.  Meta-analysis of the symptom structure of obsessive-compulsive disorder. , 2008, The American journal of psychiatry.

[52]  K. Kendler,et al.  Heritability of obsessive‐compulsive symptom dimensions , 2008, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[53]  B. Browning,et al.  Rapid and accurate haplotype phasing and missing-data inference for whole-genome association studies by use of localized haplotype clustering. , 2007, American journal of human genetics.

[54]  Manuel A. R. Ferreira,et al.  PLINK: a tool set for whole-genome association and population-based linkage analyses. , 2007, American journal of human genetics.

[55]  D. Boomsma,et al.  The Obsessive Compulsive Scale of the Child Behavior Checklist predicts obsessive-compulsive disorder: a receiver operating characteristic curve analysis. , 2006, Journal of child psychology and psychiatry, and allied disciplines.

[56]  D. Boomsma,et al.  Twin studies on obsessive-compulsive disorder: a review. , 2005, Twin research and human genetics : the official journal of the International Society for Twin Studies.

[57]  D. Boomsma,et al.  Twin Studies on Obsessive–Compulsive Disorder: A Review , 2005, Twin Research and Human Genetics.

[58]  V. Willour,et al.  Replication study supports evidence for linkage to 9p24 in obsessive-compulsive disorder. , 2004, American journal of human genetics.

[59]  C. Begley,et al.  Endophilin-1: a multifunctional protein. , 2002, The international journal of biochemistry & cell biology.

[60]  T. Takano,et al.  Beyond the role of glutamate as a neurotransmitter , 2002, Nature Reviews Neuroscience.

[61]  B. Leventhal,et al.  Genome-wide linkage analysis of families with obsessive-compulsive disorder ascertained through pediatric probands. , 2002, American journal of medical genetics.

[62]  K. Mikoshiba,et al.  Impaired learning with enhanced hippocampal long‐term potentiation in PTPδ‐deficient mice , 2000 .

[63]  A. Zohar The epidemiology of obsessive-compulsive disorder in children and adolescents. , 1999, Child and adolescent psychiatric clinics of North America.

[64]  M. Nitabach,et al.  The leech receptor protein tyrosine phosphatase HmLAR2 is concentrated in growth cones and is involved in process outgrowth. , 1998, Development.

[65]  D. V. Vactor Protein tyrosine phosphatases in the developing nervous system , 1998 .

[66]  W. Goodman,et al.  Children's Yale-Brown Obsessive Compulsive Scale: reliability and validity. , 1997, Journal of the American Academy of Child and Adolescent Psychiatry.

[67]  U. Francke,et al.  Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[68]  G. Burns,et al.  The utilization of nonpatient samples in the study of obsessive compulsive disorder. , 1995, Behaviour research and therapy.

[69]  A. Stoker Isoforms of a novel cell adhesion molecule-like protein tyrosine phosphatase are implicated in neural development , 1994, Mechanisms of Development.

[70]  C. Burton,et al.  Glutamate Genetics in Obsessive-Compulsive Disorder: A Review. , 2017, Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent.

[71]  D. Posthuma,et al.  Power in GWAS: lifting the curse of the clinical cut-off , 2013, Molecular Psychiatry.

[72]  Dan J Stein,et al.  The epidemiology of obsessive-compulsive disorder in the National Comorbidity Survey Replication , 2010, Molecular Psychiatry.

[73]  A. Preti,et al.  The psychometric discriminative properties of the Peters et al Delusions Inventory: a receiver operating characteristic curve analysis. , 2007, Comprehensive psychiatry.

[74]  Karl G. Johnson,et al.  Receptor protein tyrosine phosphatases in nervous system development. , 2003, Physiological reviews.

[75]  Robert C. Wolpert,et al.  A Review of the , 1985 .