G-quadruplex DNA drives genomic instability and represents a targetable molecular abnormality in ATRX-deficient malignant glioma
暂无分享,去创建一个
G. Riggins | J. Huse | T. Chan | Kasthuri Kannan | E. Sulman | Yuxiang Wang | Carla Danussi | Wei H. Wu | A. Wild | Jie Yang | Rachna Shah | T. Chan
[1] M. Maniati,et al. Shelterin Complex at Telomeres: Implications in Ageing , 2020, Clinical interventions in aging.
[2] E. Dassi,et al. hnRNP H/F drive RNA G-quadruplex-mediated translation linked to genomic instability and therapy resistance in glioblastoma , 2020, Nature Communications.
[3] V. Band,et al. Endogenous oxidized DNA bases and APE1 regulate the formation of G-quadruplex structures in the genome , 2020, Proceedings of the National Academy of Sciences.
[4] L. Zou,et al. Alternative lengthening of telomeres: from molecular mechanisms to therapeutic outlooks , 2020, Cell & Bioscience.
[5] A. Antoccia,et al. G-quadruplex Stabilization Fuels the ALT Pathway in ALT-positive Osteosarcoma Cells , 2020, Genes.
[6] Y. Heuzé,et al. Impact of sampling strategies and reconstruction protocols in nasal airflow simulations in fossil hominins , 2018, Proceedings of the National Academy of Sciences.
[7] O. Delattre,et al. Does ATRX germline variation predispose to osteosarcoma? Three additional cases of osteosarcoma in two ATR-X syndrome patients , 2018, European Journal of Human Genetics.
[8] R. Pearson,et al. Ribosomal DNA copy loss and repeat instability in ATRX-mutated cancers , 2018, Proceedings of the National Academy of Sciences.
[9] C. Miller,et al. Atrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling , 2018, Nature Communications.
[10] J. Maciejewski,et al. IDH1/2 Mutations Sensitize Acute Myeloid Leukemia to PARP Inhibition and This Is Reversed by IDH1/2-Mutant Inhibitors , 2018, Clinical Cancer Research.
[11] E. Mohammadi,et al. Barriers and facilitators related to the implementation of a physiological track and trigger system: A systematic review of the qualitative evidence , 2017, International journal for quality in health care : journal of the International Society for Quality in Health Care.
[12] C. Brennan,et al. Mutant-IDH1-dependent chromatin state reprogramming, reversibility, and persistence , 2017, Nature Genetics.
[13] J. Geigl,et al. A novel mutation in ATRX associated with intellectual disability, syndromic features, and osteosarcoma , 2017, Pediatric blood & cancer.
[14] Zepeng Zhang,et al. A Cisplatin Derivative Tetra-Pt(bpy) as an Oncotherapeutic Agent for Targeting ALT Cancer , 2017, Journal of the National Cancer Institute.
[15] S. Balasubramanian,et al. Local epigenetic reprogramming induced by G-quadruplex ligands. , 2017, Nature chemistry.
[16] Xiaowu Gai,et al. Inherited germline ATRX mutation in two brothers with ATR‐X syndrome and osteosarcoma , 2017, American journal of medical genetics. Part A.
[17] M. Gilbert,et al. Chemosensitivity of IDH1-Mutated Gliomas Due to an Impairment in PARP1-Mediated DNA Repair. , 2017, Cancer research.
[18] Jian Xian,et al. CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours , 2017, Nature Communications.
[19] Gregory A. Breuer,et al. 2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity , 2017, Science Translational Medicine.
[20] J. Costello,et al. Mutant IDH1 Expression Drives TERT Promoter Reactivation as Part of the Cellular Transformation Process. , 2016, Cancer research.
[21] R. Bjerkvig,et al. Rapid Conversion of Mutant IDH1 from Driver to Passenger in a Model of Human Gliomagenesis. , 2016, Molecular cancer research : MCR.
[22] Hiroshi Kimura,et al. G-quadruplex structures mark human regulatory chromatin , 2016, Nature Genetics.
[23] R. Bjerkvig,et al. Rapid Conversion of Mutant IDH1 from Driver to Passenger in a Model of Human Gliomagenesis , 2016, Molecular Cancer Research.
[24] E. Goodall,et al. Stalled replication forks within heterochromatin require ATRX for protection , 2016, Cell Death and Disease.
[25] D. Ferguson,et al. ATRX loss promotes tumor growth and impairs nonhomologous end joining DNA repair in glioma , 2016, Science Translational Medicine.
[26] H. Lipps,et al. G-quadruplexes and their regulatory roles in biology , 2015, Nucleic acids research.
[27] Junjiu Huang,et al. The Daxx/Atrx Complex Protects Tandem Repetitive Elements during DNA Hypomethylation by Promoting H3K9 Trimethylation. , 2015, Cell stem cell.
[28] D. Higgs,et al. Suppression of the alternative lengthening of telomere pathway by the chromatin remodelling factor ATRX , 2015, Nature Communications.
[29] Steven J. M. Jones,et al. Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas. , 2015, The New England journal of medicine.
[30] T. Jenuwein,et al. ATRX Plays a Key Role in Maintaining Silencing at Interstitial Heterochromatic Loci and Imprinted Genes , 2015, Cell reports.
[31] Ruslan Sadreyev,et al. ATRX Directs Binding of PRC2 to Xist RNA and Polycomb Targets , 2014, Cell.
[32] R. Pieper,et al. Mutant IDH1-driven cellular transformation increases RAD51-mediated homologous recombination and temozolomide resistance. , 2014, Cancer research.
[33] D. Higgs,et al. ATRX Dysfunction Induces Replication Defects in Primary Mouse Cells , 2014, PloS one.
[34] Caterina Giannini,et al. Benefit from procarbazine, lomustine, and vincristine in oligodendroglial tumors is associated with mutation of IDH. , 2014, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[35] L. Deangelis,et al. Glioblastoma and other malignant gliomas: a clinical review. , 2013, JAMA.
[36] Jesse M. Platt,et al. Detection of G-quadruplex DNA in mammalian cells , 2013, Nucleic acids research.
[37] C. Brennan,et al. Efficient induction of differentiation and growth inhibition in IDH1 mutant glioma cells by the DNMT Inhibitor Decitabine , 2013, Oncotarget.
[38] D. Higgs,et al. The chromatin remodeller ATRX: a repeat offender in human disease. , 2013, Trends in biochemical sciences.
[39] T. Holland-Letz,et al. ATRX loss refines the classification of anaplastic gliomas and identifies a subgroup of IDH mutant astrocytic tumors with better prognosis , 2013, Acta Neuropathologica.
[40] Fang Wang,et al. An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells , 2013, Science.
[41] K. Shin‐ya,et al. Atrx deficiency induces telomere dysfunction, endocrine defects, and reduced life span. , 2013, The Journal of clinical investigation.
[42] Shankar Balasubramanian,et al. G-Quadruplex structures are stable and detectable in human genomic DNA , 2013, Nature Communications.
[43] Junjie Chen,et al. Alpha Thalassemia/Mental Retardation Syndrome X-linked Gene Product ATRX Is Required for Proper Replication Restart and Cellular Resistance to Replication Stress* , 2013, The Journal of Biological Chemistry.
[44] R. McLendon,et al. Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas , 2012, Oncotarget.
[45] W. Hahn,et al. Loss of ATRX, Genome Instability, and an Altered DNA Damage Response Are Hallmarks of the Alternative Lengthening of Telomeres Pathway , 2012, PLoS genetics.
[46] Chris Sander,et al. miR-34a Repression in Proneural Malignant Gliomas Upregulates Expression of Its Target PDGFRA and Promotes Tumorigenesis , 2012, PloS one.
[47] B. Garcia,et al. ATRX-mediated chromatin association of histone variant macroH2A1 regulates α-globin expression. , 2012, Genes & development.
[48] A. Viale,et al. IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype , 2012, Nature.
[49] Stephen P. Jackson,et al. Small molecule-induced DNA damage identifies alternative DNA structures in human genes , 2012, Nature chemical biology.
[50] David T. W. Jones,et al. Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma , 2012, Nature.
[51] Thomas Helleday,et al. The underlying mechanism for the PARP and BRCA synthetic lethality: Clearing up the misunderstandings , 2011, Molecular oncology.
[52] R. McLendon,et al. Altered Telomeres in Tumors with ATRX and DAXX Mutations , 2011, Science.
[53] Katrin Paeschke,et al. DNA Replication through G-Quadruplex Motifs Is Promoted by the Saccharomyces cerevisiae Pif1 DNA Helicase , 2011, Cell.
[54] Stephen Neidle,et al. Targeting G-quadruplexes in gene promoters: a novel anticancer strategy? , 2011, Nature Reviews Drug Discovery.
[55] Steven J. M. Jones,et al. ATR-X Syndrome Protein Targets Tandem Repeats and Influences Allele-Specific Expression in a Size-Dependent Manner , 2010, Cell.
[56] S. De,et al. DNA secondary structures and epigenetic determinants of cancer genome evolution , 2010, Nature Structural &Molecular Biology.
[57] T. Helleday,et al. Pathways of mammalian replication fork restart , 2010, Nature Reviews Molecular Cell Biology.
[58] C. Baumann,et al. Loss of Maternal ATRX Results in Centromere Instability and Aneuploidy in the Mammalian Oocyte and Pre-Implantation Embryo , 2010, PLoS genetics.
[59] C. Allis,et al. Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres , 2010, Proceedings of the National Academy of Sciences.
[60] A. Hamiche,et al. The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3. , 2010, Genes & development.
[61] R. Hannan,et al. ATRX interacts with H3.3 in maintaining telomere structural integrity in pluripotent embryonic stem cells. , 2010, Genome research.
[62] Amy Lin,et al. Anticancer activity of CX-3543: a direct inhibitor of rRNA biogenesis. , 2009, Cancer research.
[63] M. Foiani,et al. The checkpoint response to replication stress. , 2009, DNA repair.
[64] E. Gilson,et al. Stabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway , 2009, Nucleic acids research.
[65] E. Liu,et al. Regulation of Estrogen Receptor-mediated Long Range Transcription via Evolutionarily Conserved Distal Response Elements* , 2008, Journal of Biological Chemistry.
[66] Joshua M. Korn,et al. Integrated genotype calling and association analysis of SNPs, common copy number polymorphisms and rare CNVs , 2008, Nature Genetics.
[67] S. Balasubramanian,et al. Selective recognition of a DNA G-quadruplex by an engineered antibody. , 2008, Biochemistry.
[68] F. Dick,et al. Loss of ATRX leads to chromosome cohesion and congression defects , 2008, The Journal of cell biology.
[69] M. Mangelsdorf,et al. The chromatin-remodeling protein ATRX is critical for neuronal survival during corticogenesis. , 2005, The Journal of clinical investigation.
[70] N. Laperriere,et al. Radiotherapy for newly diagnosed malignant glioma in adults: a systematic review. , 2002, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.
[71] R. Cawthon. Telomere measurement by quantitative PCR. , 2002, Nucleic acids research.
[72] M. Pflumm. The role of DNA replication in chromosome condensation , 2002, BioEssays : news and reviews in molecular, cellular and developmental biology.
[73] K. Aldape,et al. Formation of intracranial tumors by genetically modified human astrocytes defines four pathways critical in the development of human anaplastic astrocytoma. , 2001, Cancer research.
[74] D. Higgs,et al. Molecular-clinical spectrum of the ATR-X syndrome. , 2000, American journal of medical genetics.
[75] N. Maizels,et al. The Bloom’s Syndrome Helicase Unwinds G4 DNA* , 1998, The Journal of Biological Chemistry.
[76] D P Byar,et al. Randomized comparisons of radiotherapy and nitrosoureas for the treatment of malignant glioma after surgery. , 1980, The New England journal of medicine.
[77] E. Alexander,et al. Evaluation of BCNU and/or radiotherapy in the treatment of anaplastic gliomas. A cooperative clinical trial. , 1978, Journal of neurosurgery.
[78] G. Fraedrich,et al. Juvenile recurrent respiratory papillomatosis: Still a mystery disease with difficult management , 2007, Head & neck.
[79] R. McLendon,et al. Adaptive Evolution of the GDH2 Allosteric Domain Promotes Gliomagenesis by Resolving IDH1R132H-Induced Metabolic Liabilities. , 2018, Cancer research.
[80] K. Shirahige,et al. Chromatin immunoprecipitation protocol for mammalian cells. , 2014, Methods in molecular biology.
[81] E. Kirkness,et al. A model of a patient-derived IDH1 mutant anaplastic astrocytoma with alternative lengthening of telomeres , 2014, Journal of Neuro-Oncology.
[82] J. Uhm. IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype , 2012 .
[83] D. Louis. WHO classification of tumours of the central nervous system , 2007 .
[84] A. Olshen,et al. A Faster Circular Binary Segmentation Algorithm for the Analysis of Array Cgh Data , 2022 .