In Vitro and In Vivo Metabolism and Pharmacokinetics of bis [(T-Butyl)-S-acyl-2-thioethyl]-β-L-2′,3′-dideoxy-5-fluorocytidine Monophosphate
暂无分享,去创建一个
H. McClure | R. Schinazi | J. Imbach | J. Sommadossi | G. Gosselin | A. Loi | L. Placidi | E. Cretton-scott | Lee T. Martin | A. Faraj
[1] H. McClure,et al. Pharmacokinetics of β-l-2′,3′-Dideoxy-5-Fluorocytidine in Rhesus Monkeys , 1997, Antimicrobial Agents and Chemotherapy.
[2] J. Imbach,et al. The S-acyl-2-thioethyl pronucleotide approach applied to acyclovir: part I. Synthesis and in vitro anti-hepatitis B virus activity of bis(S-acyl-2-thioethyl)phosphotriester derivatives of acyclovir. , 1999, Antiviral research.
[3] B. Robbins,et al. Anti-Human Immunodeficiency Virus Activity and Cellular Metabolism of a Potential Prodrug of the Acyclic Nucleoside Phosphonate 9-R-(2-Phosphonomethoxypropyl)adenine (PMPA), Bis(isopropyloxymethylcarbonyl)PMPA , 1998, Antimicrobial Agents and Chemotherapy.
[4] H. Thomas,et al. Therapies for Viral Hepatitis , 1998 .
[5] C. Hendrix,et al. Anti-human immunodeficiency virus (HIV) activity, safety, and pharmacokinetics of adefovir dipivoxil (9-[2-(bis-pivaloyloxymethyl)-phosphonylmethoxyethyl]adenine) in HIV-infected patients. , 1997, The Journal of infectious diseases.
[6] R. Schinazi,et al. Effect of stereoisomerism on the cellular pharmacology of beta-enantiomers of cytidine analogs in Hep-G2 cells. , 1997, Biochemical pharmacology.
[7] H. Pelicano,et al. Synthesis, in vitro antiviral evaluation, and stability studies of bis(S-acyl-2-thioethyl) ester derivatives of 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA) as potential PMEA prodrugs with improved oral bioavailability. , 1996, Journal of medicinal chemistry.
[8] J. Imbach,et al. Comparison of Cytotoxicity of Mononucleoside Phosphotriester Derivatives Bearing Biolabile Phosphate Protecting Groups in Normal Human Bone Marrow Progenitor Cells , 1996 .
[9] J. Flaherty,et al. Famciclovir for Treatment of Herpesvirus Infections , 1996, The Annals of pharmacotherapy.
[10] K. S. Gill,et al. The Clinical Pharmacokinetics of Famciclovir , 1996, Clinical pharmacokinetics.
[11] J. Imbach,et al. New insights regarding the potential of the pronucleotide approach in antiviral chemotherapy. , 1996, Acta biochimica Polonica.
[12] A. Collier,et al. Clinical pharmacokinetics of adefovir in human immunodeficiency virus type 1-infected patients , 1995, Antimicrobial agents and chemotherapy.
[13] J. Imbach,et al. Mononucleoside phosphotriester derivatives with S-acyl-2-thioethyl bioreversible phosphate-protecting groups: intracellular delivery of 3'-azido-2',3'-dideoxythymidine 5'-monophosphate. , 1995, Journal of medicinal chemistry.
[14] G. de Sousa,et al. Disposition and metabolism of the angiogenic moderator O-(chloroacetyl-carbamoyl) fumagillol (TNP-470; AGM-1470) in human hepatocytes and tissue microsomes. , 1995, Cancer research.
[15] N. Bischofberger,et al. Minireview: nucleotide prodrugs. , 1995, Antiviral research.
[16] M. Connelly,et al. Metabolic diversity and antiviral activities of acyclic nucleoside phosphonates. , 1995, Molecular pharmacology.
[17] D. Farquhar,et al. 5'-[4-(Pivaloyloxy)-1,3,2-dioxaphosphorinan-2-yl]-2'-deoxy-5-fluorouridine: a membrane-permeating prodrug of 5-fluoro-2'-deoxyuridylic acid (FdUMP). , 1995, Journal of medicinal chemistry.
[18] D. Farquhar,et al. Synthesis and antitumor evaluation of bis[(pivaloyloxy)methyl] 2'-deoxy-5-fluorouridine 5'-monophosphate (FdUMP): a strategy to introduce nucleotides into cells. , 1994, Journal of medicinal chemistry.
[19] J. Wakefield,et al. Inhibition of human immunodeficiency virus type 1 reverse transcriptase by the 5'-triphosphate beta enantiomers of cytidine analogs , 1994, Antimicrobial Agents and Chemotherapy.
[20] R. Schinazi,et al. Pure nucleoside enantiomers of beta-2',3'-dideoxycytidine analogs are selective inhibitors of hepatitis B virus in vitro , 1994, Antimicrobial Agents and Chemotherapy.
[21] H. Pelicano,et al. Equal inhibition of the replication of human immunodeficiency virus in human T-cell culture by ddA bis(SATE)phosphotriester and 3'-azido-2',3'-dideoxythymidine. , 1994, Biochemical pharmacology.
[22] R. Schinazi,et al. Anti-human immunodeficiency virus activities of the beta-L enantiomer of 2',3'-dideoxycytidine and its 5-fluoro derivative in vitro , 1994, Antimicrobial Agents and Chemotherapy.
[23] D. Nelson,et al. Intracellular metabolism of (-)- and (+)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine in HepG2 derivative 2.2.15 (subclone P5A) cells , 1994, Antimicrobial Agents and Chemotherapy.
[24] S. Kahn,et al. Decomposition Pathways of the Mono- and Bis(Pivaloyloxymethyl) Esters of Azidothymidine 5′-Monophosphate in Cell Extract and in Tissue Culture Medium: An Application of the ‘on-line ISRP-Cleaning’ HPLC Technique , 1994 .
[25] Elias S. J. Arnér,et al. Deoxycytidine and 2',3'-dideoxycytidine metabolism in human monocyte-derived macrophages. A study of both anabolic and catabolic pathways. , 1993, Biochemical and biophysical research communications.
[26] J. Imbach,et al. Intracellular delivery of nucleoside monophosphates through a reductase-mediated activation process. , 1993, Antiviral research.
[27] M. Connelly,et al. Metabolism and in vitro antiretroviral activities of bis(pivaloyloxymethyl) prodrugs of acyclic nucleoside phosphonates , 1993, Antimicrobial Agents and Chemotherapy.
[28] G. Degols,et al. Inhibition of HIV-1 replication in cultured cells with phosphorylated dideoxyuridine derivatives encapsulated in immunoliposomes. , 1993, Antiviral research.
[29] W. Plunkett,et al. Membrane-permeable dideoxyuridine 5'-monophosphate analogue inhibits human immunodeficiency virus infection. , 1992, Molecular pharmacology.
[30] J. Balzarini,et al. Potent DNA chain termination activity and selective inhibition of human immunodeficiency virus reverse transcriptase by 2',3'-dideoxyuridine-5'-triphosphate. , 1990, Molecular pharmacology.
[31] D. Farquhar,et al. Synthesis and biological evaluation of 9-[5'-(2-oxo-1,3,2-oxazaphosphorinan-2-yl)-beta-D-arabinosyl]ade nine and 9-[5'-(2-oxo-1,3,2-dioxaphosphorinan-2-yl)-beta-D-arabinosyl]ade nine: potential neutral precursors of 9-[beta-D-arabinofuranosyl]adenine 5'-monophosphate. , 1985, Journal of medicinal chemistry.
[32] D. Farquhar,et al. Synthesis and biological evaluation of neutral derivatives of 5-fluoro-2'-deoxyuridine 5'-phosphate. , 1983, Journal of medicinal chemistry.
[33] C Gomeni,et al. AUTOMOD: a polyalgorithm for an integrated analysis of linear pharmacokinetic models. , 1979, Computers in biology and medicine.