Regulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and angiogenesis by an insulin-like growth factor-I receptor autocrine loop in human pancreatic cancer.
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L. Ellis | O. Stoeltzing | Wenbiao Liu | N. Reinmuth | F. Fan | A. Parikh | C. Bucana | Douglas B. Evans | G. Semenza
[1] M. Grant,et al. Insulin-like growth factor I acts as an angiogenic agent in rabbit cornea and retina: comparative studies with basic fibroblast growth factor , 1993, Diabetologia.
[2] L. Ellis,et al. Vascular endothelial growth factor is upregulated by interleukin-1β in human vascular smooth muscle cells via the P38 mitogen-activated protein kinase pathway , 2004, Angiogenesis.
[3] H. Friess,et al. Hypoxia-Inducible Factor 1 Regulates Vascular Endothelial Growth Factor Expression in Human Pancreatic Cancer , 2003, Pancreas.
[4] L. Ellis,et al. Effect of the vascular endothelial growth factor receptor‐2 antibody DC101 plus gemcitabine on growth, metastasis and angiogenesis of human pancreatic cancer growing orthotopically in nude mice , 2002, International journal of cancer.
[5] L. Ellis,et al. Insulin-like Growth Factor 1 Induces Hypoxia-inducible Factor 1-mediated Vascular Endothelial Growth Factor Expression, Which is Dependent on MAP Kinase and Phosphatidylinositol 3-Kinase Signaling in Colon Cancer Cells* , 2002, The Journal of Biological Chemistry.
[6] L. Ellis,et al. Impact of Insulin-Like Growth Factor Receptor-I Function on Angiogenesis, Growth, and Metastasis of Colon Cancer , 2002, Laboratory Investigation.
[7] L. Ellis,et al. Blockade of insulin-like growth factor I receptor function inhibits growth and angiogenesis of colon cancer. , 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.
[8] Michael I Dorrell,et al. Insulin-like growth factor 2 and potential regulators of hemangioma growth and involution identified by large-scale expression analysis , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[9] L. Ellis,et al. Role of P38 MAPK, AP-1, and NF-κB in interleukin-1β-induced IL-8 expression in human vascular smooth muscle cells , 2002 .
[10] I. Fidler,et al. Blockade of vascular endothelial growth factor receptor and epidermal growth factor receptor signaling for therapy of metastatic human pancreatic cancer. , 2002, Cancer research.
[11] L. Hennighausen,et al. Circulating insulin-like growth factor-I levels regulate colon cancer growth and metastasis. , 2002, Cancer research.
[12] K. Miyazaki,et al. Cyclooxygenase-2 expression in endometrial cancer: correlation with microvessel count and expression of vascular endothelial growth factor and thymidine phosphorylase. , 2002, Human pathology.
[13] P. Bushel,et al. Insulin-like growth factor-1 inscribes a gene expression profile for angiogenic factors and cancer progression in breast epithelial cells. , 2002, Neoplasia.
[14] L. Ellis,et al. Role of P38 MAPK, AP-1, and NF-kappaB in interleukin-1beta-induced IL-8 expression in human vascular smooth muscle cells. , 2002, Cytokine.
[15] L. Ellis,et al. Inhibition of growth and metastasis of human pancreatic cancer growing in nude mice by PTK 787/ZK222584, an inhibitor of the vascular endothelial growth factor receptor tyrosine kinases. , 2001, Cancer biotherapy & radiopharmaceuticals.
[16] Lei Xu,et al. Pancreas Microenvironment Promotes VEGF Expression and Tumor Growth: Novel Window Models for Pancreatic Tumor Angiogenesis and Microcirculation , 2001, Laboratory Investigation.
[17] M. Asaka,et al. Constitutive expression of hypoxia-inducible factor-1alpha renders pancreatic cancer cells resistant to apoptosis induced by hypoxia and nutrient deprivation. , 2001, Cancer research.
[18] M. Schindl,et al. Expression of hypoxia‐inducible factor–1α in oligodendrogliomas , 2001 .
[19] J. Knezetic,et al. Receptors and Ligands for Autocrine Growth Pathways Are Up-regulated When Pancreatic Cancer Cells Are Adapted to Serum-Free Culture , 2001, Pancreas.
[20] J. Testa,et al. AKT activation up-regulates insulin-like growth factor I receptor expression and promotes invasiveness of human pancreatic cancer cells. , 2001, Cancer research.
[21] L. Ellis,et al. The effects of angiopoietin-1 and -2 on tumor growth and angiogenesis in human colon cancer. , 2001, Cancer research.
[22] L. Magnelli,et al. Cyclooxygenase-2 pathway correlates with VEGF expression in head and neck cancer. Implications for tumor angiogenesis and metastasis. , 2001, Neoplasia.
[23] I. Fidler,et al. Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma. , 2000, Cancer research.
[24] D B Evans,et al. Epidermal growth factor receptor blockade with C225 plus gemcitabine results in regression of human pancreatic carcinoma growing orthotopically in nude mice by antiangiogenic mechanisms. , 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.
[25] H. Esumi,et al. Regulation of vascular endothelial growth factor expression by insulin‐like growth factor‐I in endometrial adenocarcinoma cells , 2000, International journal of cancer.
[26] Lois E. H. Smith,et al. Regulation of vascular endothelial growth factor-dependent retinal neovascularization by insulin-like growth factor-1 receptor , 1999, Nature Medicine.
[27] D A Hilton,et al. Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. , 1999, Cancer research.
[28] T. Yeatman,et al. Expression of insulin-like growth factor-1 receptor in human colorectal cancer. , 1999, Human pathology.
[29] G. Christofori,et al. An Insulin-like Growth Factor-mediated, Phosphatidylinositol 3′ Kinase-independent Survival Signaling Pathway in β Tumor Cells , 1999 .
[30] G. Semenza,et al. Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2. , 1999, Cancer research.
[31] G Nilsson,et al. Expression of insulin-like growth factor-1 receptor in synovial sarcoma: association with an aggressive phenotype. , 1999, Cancer research.
[32] I. Fidler,et al. In vivo selection and characterization of metastatic variants from human pancreatic adenocarcinoma by using orthotopic implantation in nude mice. , 1999, Neoplasia.
[33] J. Zalcberg,et al. Altered expression of the IGF-1 receptor in a tamoxifen-resistant human breast cancer cell line , 1999, British Journal of Cancer.
[34] G. Christofori,et al. An insulin-like growth factor-mediated, phosphatidylinositol 3' kinase-independent survival signaling pathway in beta tumor cells. , 1999, Cancer research.
[35] L. Ellis,et al. Regulation of vascular endothelial growth factor expression in human colon cancer by insulin-like growth factor-I. , 1998, Cancer research.
[36] A. Hoeflich,et al. Src Stimulates Insulin-like Growth Factor I (igf-i)-dependent Cell Proliferation by Increasing Igf-i Receptor Number in Human Pancreatic Carcinoma Cells1 Overexpression of Kinase-activated Srcy527f Resulted in a Signif Icant Increase of Insulin-like Growth Factor I (igf-i)-dependent Cell pro Liferat , 2022 .
[37] P. Carmeliet,et al. Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis , 1998, Nature.
[38] K. W. Kim,et al. Insulin-like growth factor II induced by hypoxia may contribute to angiogenesis of human hepatocellular carcinoma. , 1998, Cancer research.
[39] P. Brodt,et al. Enhanced invasion and liver colonization by lung carcinoma cells overexpressing the type 1 insulin-like growth factor receptor. , 1998, Experimental cell research.
[40] M. Rubini,et al. The IGF-I receptor in cell growth, transformation and apoptosis. , 1997, Biochimica et biophysica acta.
[41] H. Werner,et al. The insulin-like growth factor-I receptor signaling pathways are important for tumorigenesis and inhibition of apoptosis. , 1997, Critical reviews in oncogenesis.
[42] D. Donner,et al. Induction of Vascular Endothelial Growth Factor by Insulin-like Growth Factor 1 in Colorectal Carcinoma* , 1996, The Journal of Biological Chemistry.
[43] J. Battey,et al. Insulin-like Growth Factor Expression in Human Cancer Cell Lines (*) , 1996, The Journal of Biological Chemistry.
[44] C. Woodworth,et al. Overexpression of the insulin-like growth factor-1 receptor and autocrine stimulation in human cervical cancer cells. , 1996, Cancer research.
[45] W. Strodel,et al. Increased tumorigenicity in the human pancreatic cell line MIA PaCa‐2 Is associated with an aberrant regulation of an IGF‐1 autocrine loop and lack of expression of the TGF‐β type RII receptor , 1995, Journal of cellular physiology.
[46] R. Baserga,et al. Insulin-like growth factor-I receptor. Its role in cell proliferation, apoptosis, and tumorigenicity. , 1995, Laboratory investigation; a journal of technical methods and pathology.
[47] M. Korc,et al. Insulin-like growth factor I overexpression in human pancreatic cancer: evidence for autocrine and paracrine roles. , 1995, Cancer research.
[48] M. Plebani,et al. Insulin-like growth factor-I, interleukin-1 α and β in pancreatic cancer: role in tumor invasiveness and associated diabetes , 1995 .
[49] M. Plebani,et al. Insulin-like growth factor-I, interleukin-1 alpha and beta in pancreatic cancer: role in tumor invasiveness and associated diabetes. , 1995, International journal of clinical & laboratory research.
[50] L. Ellis,et al. The implications of angiogenesis for the biology and therapy of cancer metastasis , 1994, Cell.
[51] D. Coppola,et al. A functional insulin-like growth factor I receptor is required for the mitogenic and transforming activities of the epidermal growth factor receptor , 1994, Molecular and cellular biology.
[52] S. Asa,et al. Dominant negative inhibition of tumorigenesis in vivo by human insulin-like growth factor I receptor mutant. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[53] A. Kumar,et al. Distribution and relevance of insulin-like growth factor-I receptor in metanephric development. , 1993, Kidney international.
[54] S. Melmed,et al. Human insulin-like growth factor I receptor function in pituitary cells is suppressed by a dominant negative mutant. , 1992, The Journal of clinical investigation.
[55] J. Folkman,et al. The role of angiogenesis in tumor growth. , 1992, Seminars in cancer biology.
[56] E. Ohmura,et al. Insulin-like Growth Factor I and Transforming Growth Factor α as Autocrine Growth Factors in Human Pancreatic Cancer Cell Growth , 1990 .
[57] W. Sly,et al. Insulin-like growth factor receptor expression and function in human breast cancer. , 1990, Cancer research.
[58] E. Ohmura,et al. Insulin-like growth factor I and transforming growth factor alpha as autocrine growth factors in human pancreatic cancer cell growth. , 1990, Cancer research.