Phage display selection of peptides that affect prostate carcinoma cells attachment and invasion

Prostate cancer‐specific proteins must be identified to serve as diagnostic and prognostic markers. Cell surface proteins are especially important, because they have potential utility as diagnostic markers and therapeutic targets. Identification of ligands for these proteins will allow use of these ligands as diagnostic and therapeutic tools and permit the investigation of receptor function. We performed a search for peptide ligands to prostate cancer cell‐specific receptors.

[1]  K. Brown,et al.  New approaches for cell-specific targeting: identification of cell-selective peptides from combinatorial libraries. , 2000, Current opinion in chemical biology.

[2]  M. Stack,et al.  Membrane associated matrix metalloproteinases in metastasis. , 1999, BioEssays : news and reviews in molecular, cellular and developmental biology.

[3]  F. Berditchevski,et al.  Function of α3β1–Tetraspanin Protein Complexes in Tumor Cell Invasion. Evidence for the Role of the Complexes in Production of Matrix Metalloproteinase 2 (Mmp-2) , 1999, The Journal of cell biology.

[4]  M. Goligorsky,et al.  RGD‐recognizing integrins mediate interactions of human prostate carcinoma cells with endothelial cells in vitro , 1999, The Prostate.

[5]  W. Arap,et al.  Identification of receptor ligands with phage display peptide libraries. , 1999, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[6]  Erkki Ruoslahti,et al.  Membrane Dipeptidase Is the Receptor for a Lung-targeting Peptide Identified by in Vivo Phage Display* , 1999, The Journal of Biological Chemistry.

[7]  A. Horwitz,et al.  Identification of a Domain on the Integrin α5Subunit Implicated in Cell Spreading and Signaling* , 1998, The Journal of Biological Chemistry.

[8]  M. Chen,et al.  Isolation and characterization of PAGE-1 and GAGE-7. New genes expressed in the LNCaP prostate cancer progression model that share homology with melanoma-associated antigens. , 1998, The Journal of biological chemistry.

[9]  T. Suda,et al.  Overexpression of C-terminal Src Kinase Homologous Kinase Suppresses Activation of Lyn Tyrosine Kinase Required for VLA5-mediated Dami Cell Spreading* , 1998, The Journal of Biological Chemistry.

[10]  J M Thornton,et al.  Small binding proteins selected from a combinatorial repertoire of knottins displayed on phage. , 1998, Journal of molecular biology.

[11]  E. Ruoslahti,et al.  Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model. , 1998, Science.

[12]  V. Laudone,et al.  Angiogenesis and prostate cancer: in vivo and in vitro expression of angiogenesis factors by prostate cancer cells. , 1998, Urology.

[13]  T. Pawson,et al.  The discoidin domain receptor tyrosine kinases are activated by collagen. , 1997, Molecular cell.

[14]  G. Yancopoulos,et al.  An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors. , 1997, Molecular cell.

[15]  J. Wikberg,et al.  Phage Display Selection on Whole Cells Yields a Peptide Specific for Melanocortin Receptor 1* , 1997, The Journal of Biological Chemistry.

[16]  W. Fair,et al.  Prostate‐specific membrane antigen , 1997, The Prostate.

[17]  D. Grignon,et al.  Diagnostic and prognostic markers for human prostate cancer , 1997, The Prostate.

[18]  M. Webber,et al.  Immortalized and tumorigenic adult human prostatic epithelial cell lines: Characteristics and applications. Part 3. Oncogenes, suppressor genes, and applications , 1997, The Prostate.

[19]  D. Bostwick,et al.  Platelet‐derived growth factor A and B chains and the α and β receptors in prostatic intraepithelial neoplasia , 1996 .

[20]  G. P. Smith,et al.  A library of organic landscapes on filamentous phage. , 1996, Protein engineering.

[21]  B. Clark,et al.  A model phage display subtraction method with potential for analysis of differential gene expression , 1996, FEBS letters.

[22]  Erkki Ruoslahti,et al.  Organ targeting In vivo using phage display peptide libraries , 1996, Nature.

[23]  William J. Dower,et al.  Toward cell–targeting gene therapy vectors: Selection of cell–binding peptides from random peptide–presenting phage libraries , 1996, Nature Medicine.

[24]  Ronald W. Barrett,et al.  Peptides Which Bind to E-selectin and Block Neutrophil Adhesion (*) , 1995, The Journal of Biological Chemistry.

[25]  A. Folgori,et al.  A general strategy to identify mimotopes of pathological antigens using only random peptide libraries and human sera. , 1994, The EMBO journal.

[26]  P. Scardino,et al.  Association of transforming growth factor-beta 1 with prostate cancer: an immunohistochemical study. , 1993, Human pathology.

[27]  P. Sluss,et al.  Insulin‐like growth factor I: Action and receptor characterization in human prostate cancer cell lines , 1993, The Prostate.

[28]  M. Gleave,et al.  Prostate and bone fibroblasts induce human prostate cancer growth in vivo: implications for bidirectional tumor-stromal cell interaction in prostate carcinoma growth and metastasis. , 1992, The Journal of urology.

[29]  W. Isaacs,et al.  Wild-type p53 suppresses growth of human prostate cancer cells containing mutant p53 alleles. , 1991, Cancer research.

[30]  A W Partin,et al.  Fourier analysis of cell motility: correlation of motility with metastatic potential. , 1989, Proceedings of the National Academy of Sciences of the United States of America.