Meta-analysis of three genome-wide association studies identifies susceptibility loci for at

and Patient recruitment and sample acquisition were undertaken by EB, MG, LM, AL, DGRE, ERM, HJWT and members of the CORGI Consortium, and by RMa, RMi, EJ and DJK. Sample preparation was performed by KH, SLS and EEMJ. Genotyping was performed and co-ordinated by LGC-C, KH, AMJ, MC, EEMJ, AW and EDo. AD and EDe supplied eQTL data.Institute of Cancer Research and local collaborators: Patient recruitment and sample acquisition to NSCCG were SP. Co-ordination of preparation and genotyping was by PB. and genotyping were by BO. Colon and Patient recruitment and sample acquisition were by SF and members of the SOCCS and COGS study teams. Sample preparation was co-ordinated by SF. Genotyping was co- ordinated ET, and JGDP performed bioinformatic analyses. Abstract Genome-wide association (GWA) studies have thus far identified 10 loci at which common variants influence the risk of developing colorectal cancer (CRC). To enhance power to identify additional loci, we conducted a meta-analysis of three GWA studies from the UK totalling 3,334 cases and 4,628 controls, followed by multiple validation analyses, involving a total of 18,095 CRC cases and 20,197 controls. We identified new associations at 4 CRC risk loci: 1q41 (rs6691170, OR=1.06, P=9.55x10 -10 ; rs6687758, OR=1.09, P=2.27x10 -9 ); 3q26.2 (rs10936599, OR=0.93, P=3.39x10 -8 ); 12q13.13 (rs11169552, OR=0.92, P=1.89x10 -10 ; rs7136702, OR=1.06, P=4.02=x10 -8 ); and 20q13.33 (rs4925386, OR=0.93, P=1.89x10 -10 ). As well as identifying multiple new CRC risk loci this analysis provides evidence that additional CRC-associated variants of similar effect size remain to be discovered.