Potential of Microfluidics and Single Cell Analysis in Metabolomics (Micrometabolomics)
暂无分享,去创建一个
[1] A. Zeng,et al. Microtechnology meets systems biology: the small molecules of metabolome as next big targets. , 2010, Journal of biotechnology.
[2] Robert T. Kennedy,et al. Quantitative monitoring of insulin secretion from single islets of Langerhans in parallel on a microfluidic chip. , 2009, Analytical chemistry.
[3] S. Bodovitz,et al. Single cell analysis: the new frontier in 'omics'. , 2010, Trends in biotechnology.
[4] Hongyuan Chen,et al. Separation of caffeine and theophylline in poly(dimethylsiloxane) microchannel electrophoresis with electrochemical detection. , 2005, Journal of chromatography. A.
[5] Daniel J Marchiarullo,et al. Towards an integrated microfluidic device for spaceflight clinical diagnostics Microchip-based solid-phase extraction of hydroxyl radical markers. , 2008, Journal of chromatography. A.
[6] A. Chaudhary,et al. Validating regulatory-compliant wide dynamic range bioanalytical assays using chip-based nanoelectrospray tandem mass spectrometry. , 2005, Rapid communications in mass spectrometry : RCM.
[7] Godfrey L. Smith,et al. Microfluidic systems to examine intercellular coupling of pairs of cardiac myocytes. , 2007, Lab on a chip.
[8] Bingcheng Lin,et al. Characterization of drug metabolites and cytotoxicity assay simultaneously using an integrated microfluidic device. , 2009, Lab on a chip.
[9] Jong Hwan Sung,et al. A micro cell culture analog (microCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs. , 2009, Lab on a chip.
[10] C D Mansfield,et al. Integration of microfluidics with biomedical infrared spectroscopy for analytical and diagnostic metabolic profiling. , 2006, IEE proceedings. Nanobiotechnology.
[11] M. Schwarz,et al. Determination of cationic neurotransmitters and metabolites in brain homogenates by microchip electrophoresis and carbon nanotube-modified amperometry. , 2007, Journal of chromatography. A.
[12] J. Michael Ramsey,et al. Microchip Capillary Electrophoresis with an Integrated Postcolumn Reactor , 1994 .
[13] Taesung Kim,et al. Microfluidic Technologies for Synthetic Biology , 2011, International journal of molecular sciences.
[14] Cécile Legallais,et al. A cocktail of metabolic probes demonstrates the relevance of primary human hepatocyte cultures in a microfluidic biochip for pharmaceutical drug screening. , 2011, International journal of pharmaceutics.
[15] Paul H. Gamache,et al. Metabolomic applications of electrochemistry/Mass spectrometry , 2004, Journal of the American Society for Mass Spectrometry.
[16] David I. Ellis,et al. Metabolomics: Current analytical platforms and methodologies , 2005 .
[17] D. Spence,et al. A microfluidic technique for monitoring bloodstream analytes indicative of C-peptide resistance in type 2 diabetes. , 2009, The Analyst.
[18] D. Beebe,et al. Fundamentals of microfluidic cell culture in controlled microenvironments. , 2010, Chemical Society reviews.
[19] Wataru Satoh,et al. On-chip culturing of hepatocytes and monitoring their ammonia metabolism. , 2009, Lab on a chip.
[20] D. Chiu,et al. High-throughput capillary-electrophoresis analysis of the contents of a single mitochondria. , 2009, Analytical chemistry.
[21] Edward S Yeung,et al. High-spatial and high-mass resolution imaging of surface metabolites of Arabidopsis thaliana by laser desorption-ionization mass spectrometry using colloidal silver. , 2010, Analytical chemistry.
[22] Jack D Henion,et al. Chip-based solid-phase extraction pretreatment for direct electrospray mass spectrometry analysis using an array of monolithic columns in a polymeric substrate. , 2003, Analytical chemistry.
[23] Charles S Henry,et al. Comparison of surfactants for dynamic surface modification of poly(dimethylsiloxane) microchips , 2005, Electrophoresis.
[24] Donald Wlodkowic,et al. Microfluidic single-cell array cytometry for the analysis of tumor apoptosis. , 2009, Analytical chemistry.
[25] Laurent Griscom,et al. Development of a Renal Microchip for In Vitro Distal Tubule Models , 2007, Biotechnology progress.
[26] S. Wakida,et al. High-throughput assay of nitric oxide metabolites in human plasma without deproteinization by lab-on-a-chip electrophoresis using a zwitterionic additive. , 2008, Journal of chromatography. A.
[27] D. J. Harrison,et al. Effects of injector geometry and sample matrix on injection and sample loading in integrated capillary electrophoresis devices , 1999, Electrophoresis.
[28] Lisa J. Mellander,et al. Temporal resolution in electrochemical imaging on single PC12 cells using amperometry and voltammetry at microelectrode arrays. , 2011, Analytical chemistry.
[29] Helen Song,et al. Millisecond kinetics on a microfluidic chip using nanoliters of reagents. , 2003, Journal of the American Chemical Society.
[30] Hidenori Nagai,et al. Simultaneous determination of nitrate and nitrite in biological fluids by capillary electrophoresis and preliminary study on their determination by microchip capillary electrophoresis. , 2004, Journal of chromatography. A.
[31] Charles S Henry,et al. Review: Microfluidic applications in metabolomics and metabolic profiling. , 2009, Analytica chimica acta.
[32] Mariusz Kowalczyk,et al. A strategy for identifying differences in large series of metabolomic samples analyzed by GC/MS. , 2004, Analytical chemistry.
[33] Jin‐Ming Lin,et al. Microfluidic cell culture and metabolism detection with electrospray ionization quadrupole time-of-flight mass spectrometer. , 2010, Analytical chemistry.
[34] Dan Bratton,et al. Static microdroplet arrays: a microfluidic device for droplet trapping, incubation and release for enzymatic and cell-based assays. , 2009, Lab on a chip.
[35] Laura J. Itle,et al. Microreactor Microfluidic Systems with Human Microsomes and Hepatocytes for use in Metabolite Studies , 2005, Biomedical microdevices.
[36] D. J. Harrison,et al. Planar chips technology for miniaturization and integration of separation techniques into monitoring systems. Capillary electrophoresis on a chip , 1992 .
[37] Kanaka Hettiarachchi,et al. Polymer-lipid microbubbles for biosensing and the formation of porous structures. , 2010, Journal of colloid and interface science.
[38] C. Hop. Use of nano-electrospray for metabolite identification and quantitative absorption, distribution, metabolism and excretion studies. , 2006, Current drug metabolism.
[39] Angela Man,et al. Toward point-of-care diagnostic metabolic fingerprinting: quantification of plasma creatinine by infrared spectroscopy of microfluidic-preprocessed samples. , 2009, The Analyst.
[40] Thomas Laurell,et al. Continuous separation of cells and particles in microfluidic systems. , 2010, Chemical Society reviews.
[41] Jun Kameoka,et al. Chip-based P450 drug metabolism coupled to electrospray ionization-mass spectrometry detection. , 2003, Analytical chemistry.
[42] Michael G. Roper,et al. Microfluidic perfusion system for automated delivery of temporal gradients to islets of Langerhans. , 2009, Analytical chemistry.
[43] Tomoyoshi Soga,et al. Metabolome analysis by capillary electrophoresis-mass spectrometry. , 2007, Journal of chromatography. A.
[44] B. Karger,et al. Microfabricated devices for capillary electrophoresis-electrospray mass spectrometry. , 1999, Analytical chemistry.
[45] K. Murayama,et al. Simultaneous measurement of monoamines, metabolites and amino acids in brain tissue and microdialysis perfusates. , 1993, Journal of chromatography.
[46] Man Bock Gu,et al. Fabrication of a bio-MEMS based cell-chip for toxicity monitoring. , 2007, Biosensors & bioelectronics.
[47] Richard M. Caprioli,et al. MALDI-FTICR imaging mass spectrometry of drugs and metabolites in tissue. , 2008, Analytical chemistry.
[48] S. Wakida,et al. High-throughput nitric oxide assay in biological fluids using microchip capillary electrophoresis. , 2006, Journal of chromatography. A.
[49] W. Matson,et al. Characterization of diet-dependent metabolic serotypes: analytical and biological variability issues in rats. , 2001, The Journal of nutrition.
[50] C. Barbas,et al. Capillary electrophoresis as a metabolomic tool in antioxidant therapy studies. , 2008, Journal of pharmaceutical and biomedical analysis.
[51] V. Dolnik,et al. Polymer wall coatings for capillary electrophoresis , 2001, Electrophoresis.
[52] Elizabeth Guihen,et al. Rapid separation of antimicrobial metabolites by microchip electrophoresis with UV linear imaging detection. , 2005, Journal of chromatography. A.
[53] Andreas Manz,et al. Microfluidics: Applications for analytical purposes in chemistry and biochemistry , 2008, Electrophoresis.
[54] J. Michael Ramsey,et al. Effects of injection schemes and column geometry on the performance of microchip electrophoresis devices , 1994 .
[55] Bifeng Liu,et al. Subsecond separation of cellular flavin coenzymes by microchip capillary electrophoresis with laser-induced fluorescence detection. , 2003, Journal of chromatography. A.
[56] Daniel T. Chiu,et al. Chemistry and biology in femtoliter and picoliter volume droplets. , 2009, Accounts of chemical research.
[57] R. Ramautar,et al. CE‐MS in metabolomics , 2009, Electrophoresis.
[58] Charles S Henry,et al. Electrode array detector for microchip capillary electrophoresis. , 2009, The Analyst.
[59] Christoph A. Merten,et al. Miniaturization and parallelization of biological and chemical assays in microfluidic devices. , 2010, Chemistry & biology.
[60] D. J. Harrison,et al. Capillary electrophoresis and sample injection systems integrated on a planar glass chip , 1992 .
[61] David J. Fischer,et al. Recent developments in electrochemical detection for microchip capillary electrophoresis , 2004, Electrophoresis.
[62] Javeed Shaikh Mohammed,et al. Microfluidic device for multimodal characterization of pancreatic islets. , 2009, Lab on a chip.
[63] Baoyue Zhang,et al. An integrated microfluidic cell array for apoptosis and proliferation analysis induction of breast cancer cells. , 2010, Biomicrofluidics.
[64] D. Beebe,et al. Physics and applications of microfluidics in biology. , 2002, Annual review of biomedical engineering.
[65] R. Contreras,et al. Total serum protein N‐glycome profiling on a capillary electrophoresis‐microfluidics platform , 2004, Electrophoresis.
[66] Andreas Manz,et al. Micro total analysis systems: latest achievements. , 2008, Analytical chemistry.
[67] Jonathan W. Song,et al. Characterization and resolution of evaporation-mediated osmolality shifts that constrain microfluidic cell culture in poly(dimethylsiloxane) devices. , 2007, Analytical chemistry.
[68] G. Chang,et al. A new method for CE-EC determination of mercaptopurine (MP) in a PMMA biochip with on-chip gold nano-electrode ensemble (GNEE) working and decouple electrodes. , 2009, Journal of nanoscience and nanotechnology.
[69] Zong-li Wang,et al. Analysis of inorganic and small organic ions by CE with amperometric detection , 2007, Electrophoresis.
[70] Godfrey L. Smith,et al. Metabolic monitoring of the electrically stimulated single heart cell within a microfluidic platform. , 2006, Lab on a chip.
[71] James W. Jorgenson,et al. Zone electrophoresis in open-tubular glass capillaries , 1981 .
[72] Noritada Kaji,et al. Microchip analysis of plant glucosinolates , 2008, Electrophoresis.
[73] Jing‐Juan Xu,et al. Determination of morphine and codeine in urine using poly(dimethylsiloxane) microchip electrophoresis with electrochemical detection. , 2007, Journal of pharmaceutical and biomedical analysis.
[74] He Zhu,et al. A microdevice for multiplexed detection of T-cell-secreted cytokines. , 2008, Lab on a chip.
[75] I. García-Pérez,et al. Metabolic fingerprinting of Schistosoma mansoni infection in mice urine with capillary electrophoresis , 2008, Electrophoresis.
[76] M. Hearn,et al. Open-tubular capillary electrochromatography coupled with electrospray ionization mass spectrometry for peptide analysis. , 2007, Analytical chemistry.
[77] J. Cooper,et al. Tumors on chips: oncology meets microfluidics. , 2010, Current opinion in chemical biology.
[78] K. Faure. Liquid chromatography on chip , 2010, Electrophoresis.
[79] Frank Kohler,et al. Deep UV laser-induced fluorescence detection of unlabeled drugs and proteins in microchip electrophoresis. , 2005, Analytical chemistry.
[80] R Kaliszan,et al. Increasing conclusiveness of metabonomic studies by chem-informatic preprocessing of capillary electrophoretic data on urinary nucleoside profiles. , 2007, Journal of pharmaceutical and biomedical analysis.
[81] J. Landers,et al. Fundamentals and practice for ultrasensitive laser‐induced fluorescence detection in microanalytical systems , 2004, Electrophoresis.
[82] Robert T Kennedy,et al. Continuous-flow enzyme assay on a microfluidic chip for monitoring glycerol secretion from cultured adipocytes. , 2009, Analytical chemistry.
[83] D. Cole,et al. Determination of homocysteine by HPLC with pulsed integrated amperometry. , 1995, Clinical chemistry.
[84] A. deMello,et al. Quantitative detection of protein expression in single cells using droplet microfluidics. , 2007, Chemical communications.
[85] I. García-Pérez,et al. Metabolic fingerprinting with capillary electrophoresis. , 2008, Journal of chromatography. A.
[86] Yiqing Lin,et al. Microscale LC-MS-NMR platform applied to the identification of active cyanobacterial metabolites. , 2008, Analytical chemistry.
[87] S. Gaskell,et al. New Applications of Mass Spectrometry in Lipid Analysis* , 2011, The Journal of Biological Chemistry.
[88] Todd Thorsen,et al. Noninvasive metabolic profiling using microfluidics for analysis of single preimplantation embryos. , 2008, Analytical chemistry.
[89] Jun Kameoka,et al. A polymeric microchip with integrated tips and in situ polymerized monolith for electrospray mass spectrometry. , 2005, Lab on a chip.