Effect of nanoparticles on the cell life cycle.

Effect of Nanoparticles on the Cell Life Cycle Morteza Mahmoudi,* Kayhan Azadmanesh, Mohammad A. Shokrgozar, W. Shane Journeay, and Sophie Laurent National Cell Bank, Pasteur Institute of Iran, Tehran, 1316943551 Iran Virology Department, Pasteur Institute of Iran, Tehran, 1316943551 Iran Nanotechnology Toxicology Consulting & Training, Inc., Nova Scotia, Canada Faculty of Medicine, Dalhousie Medical School, Dalhousie University, Halifax, Nova Scotia, Canada Department of General, Organic, and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, University of Mons, Avenue Maistriau, 19, B-7000 Mons, Belgium Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

[1]  Min Chen,et al.  Formation of nucleoplasmic protein aggregates impairs nuclear function in response to SiO2 nanoparticles. , 2005, Experimental cell research.

[2]  Karthikeyan Subramani,et al.  Magnetic resonance imaging tracking of stem cells in vivo using iron oxide nanoparticles as a tool for the advancement of clinical regenerative medicine. , 2011, Chemical reviews.

[3]  John D. Potter,et al.  Flow cytometric analysis of the cell cycle phase specificity of DNA damage induced by radiation, hydrogen peroxide and doxorubicin. , 2002, Carcinogenesis.

[4]  J. Paulauskis,et al.  Role of the Scavenger Receptor MARCO in Alveolar Macrophage Binding of Unopsonized Environmental Particles , 1999, The Journal of experimental medicine.

[5]  Eladia María Peña-Méndez,et al.  GOLD AND NANO-GOLD IN MEDICINE: OVERVIEW, TOXICOLOGY AND PERSPECTIVES , 2009 .

[6]  Jeremy N Skepper,et al.  Effect of ultrasmall superparamagnetic iron oxide nanoparticles (Ferumoxtran-10) on human monocyte-macrophages in vitro. , 2007, Biomaterials.

[7]  Robert Langer,et al.  Nanoparticle technologies for cancer therapy. , 2010, Handbook of experimental pharmacology.

[8]  P. Mastrantonio,et al.  Bordetella pertussis-Infected Human Monocyte-Derived Dendritic Cells Undergo Maturation and Induce Th1 Polarization and Interleukin-23 Expression , 2005, Infection and Immunity.

[9]  J. M. de la Fuente,et al.  Cell Response to Magnetic Glyconanoparticles: Does the Carbohydrate Matter? , 2007, IEEE Transactions on NanoBioscience.

[10]  R. Weissleder,et al.  Uptake of dextran‐coated monocrystalline iron oxides in tumor cells and macrophages , 1997, Journal of magnetic resonance imaging : JMRI.

[11]  P. Kaldis,et al.  Mammalian cell-cycle regulation: several Cdks, numerous cyclins and diverse compensatory mechanisms , 2009, Oncogene.

[12]  Choon Nam Ong,et al.  Gold Nanoparticles Induce Oxidative Damage in Lung Fibroblasts In Vitro , 2008 .

[13]  Frank Dolbeare,et al.  Bromodeoxyuridine: a diagnostic tool in biology and medicine, Part I: Historical perspectives, histochemical methods and cell kinetics , 2004, The Histochemical Journal.

[14]  F. Faraci,et al.  The role of oxidative stress and NADPH oxidase in cerebrovascular disease. , 2008, Trends in molecular medicine.

[15]  Michael N. Helmus,et al.  How to commercialize nanotechnology , 2006, Nature nanotechnology.

[16]  Werner A. Kaiser,et al.  Cytotoxicity of selected magnetic fluids on human adenocarcinoma cells , 2003 .

[17]  B. Sanderson,et al.  Cyto- and genotoxicity of ultrafine TiO2 particles in cultured human lymphoblastoid cells. , 2007, Mutation research.

[18]  Doris A Taylor,et al.  Improved Efficacy of Stem Cell Labeling for Magnetic Resonance Imaging Studies by the Use of Cationic Liposomes , 2003, Cell transplantation.

[19]  Mansoo Choi,et al.  Body Distribution of Inhaled Fluorescent Magnetic Nanoparticles in the Mice , 2008, Journal of occupational health.

[20]  Abbas S. Milani,et al.  Synthesis, surface architecture and biological response of superparamagnetic iron oxide nanoparticles for application in drug delivery: a review , 2010 .

[21]  Vicki Stone,et al.  Toxicology of nanoparticles: A historical perspective , 2007 .

[22]  L. Kamentsky,et al.  Microscope-based multiparameter laser scanning cytometer yielding data comparable to flow cytometry data. , 1991, Cytometry.

[23]  L. Fang,et al.  Bioeffects of different functionalized silica nanoparticles on HaCaT cell line , 2006 .

[24]  Peter van Gelderen,et al.  Magnetodendrimers allow endosomal magnetic labeling and in vivo tracking of stem cells , 2001, Nature Biotechnology.

[25]  David Kirkland,et al.  An investigation of the photo-clastogenic potential of ultrafine titanium dioxide particles. , 2007, Mutation research.

[26]  E. P. Hunter,et al.  Reaction mechanisms of peroxyl and C-centered radicals with sulfhydryls. , 1986, Journal of free radicals in biology & medicine.

[27]  S. Soenen,et al.  Assessing cytotoxicity of (iron oxide-based) nanoparticles: an overview of different methods exemplified with cationic magnetoliposomes. , 2009, Contrast media & molecular imaging.

[28]  P. Couvreur,et al.  A new nanomedicine of gemcitabine displays enhanced anticancer activity in sensitive and resistant leukemia types. , 2007, Journal of controlled release : official journal of the Controlled Release Society.

[29]  Mark R Wiesner,et al.  In vitro interactions between DMSA-coated maghemite nanoparticles and human fibroblasts: A physicochemical and cyto-genotoxical study. , 2006, Environmental science & technology.

[30]  Sara Linse,et al.  Understanding the nanoparticle–protein corona using methods to quantify exchange rates and affinities of proteins for nanoparticles , 2007, Proceedings of the National Academy of Sciences.

[31]  M. El-Sayed,et al.  Nuclear targeting of gold nanoparticles in cancer cells induces DNA damage, causing cytokinesis arrest and apoptosis. , 2010, Journal of the American Chemical Society.

[32]  R. Weissleder,et al.  Cellular Uptake and Trafficking of a Prototypical Magnetic Iron Oxide Label In Vitro , 1995, Investigative radiology.

[33]  Richard A. L. Jones.  Nanotechnology, energy and markets. , 2009, Nature nanotechnology.

[34]  A. Jasanoff,et al.  Calcium-sensitive MRI contrast agents based on superparamagnetic iron oxide nanoparticles and calmodulin , 2006, Proceedings of the National Academy of Sciences.

[35]  Arezou A Ghazani,et al.  Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells. , 2006, Nano letters.

[36]  Sungho Jin,et al.  Nanotoxicity of iron oxide nanoparticle internalization in growing neurons. , 2007, Biomaterials.

[37]  J. Gearhart,et al.  In vitro toxicity of nanoparticles in BRL 3A rat liver cells. , 2005, Toxicology in vitro : an international journal published in association with BIBRA.

[38]  G. Oberdörster,et al.  Nanotoxicology: An Emerging Discipline Evolving from Studies of Ultrafine Particles , 2005, Environmental health perspectives.

[39]  G. Kaloyanides.  Antibiotic-related nephrotoxicity. , 1994, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[40]  S. M. Robinson,et al.  Transport of Human Immunodeficiency Virus Type 1 Pseudoviruses across the Blood-Brain Barrier: Role of Envelope Proteins and Adsorptive Endocytosis , 2001, Journal of Virology.

[41]  Tilman Grune,et al.  Iron oxide particles for molecular magnetic resonance imaging cause transient oxidative stress in rat macrophages. , 2004, Free radical biology & medicine.

[42]  Katharina D'Herde,et al.  Apoptosis and necrosis: detection, discrimination and phagocytosis. , 2008, Methods.

[43]  H. Demir,et al.  Conjugated polymer nanoparticles. , 2010, Nanoscale.

[44]  T. Pisitkun,et al.  Exosomes in urine: who would have thought...? , 2007, Kidney international.

[45]  H. Jeng,et al.  Toxicity of Metal Oxide Nanoparticles in Mammalian Cells , 2006, Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering.

[46]  N. Sharon,et al.  Nonopsonic phagocytosis of microorganisms. , 1995, Annual review of microbiology.

[47]  R. White,et al.  Flow cytometry after bromodeoxyuridine labeling to measure S and G2+M phase durations plus doubling times in vitro and in vivo , 2006, Nature Protocols.

[48]  M. Gago-Domínguez,et al.  Role of lipid peroxidation and oxidative stress in the association between thyroid diseases and breast cancer. , 2008, Critical reviews in oncology/hematology.

[49]  Xinglu Huang,et al.  The promotion of human malignant melanoma growth by mesoporous silica nanoparticles through decreased reactive oxygen species. , 2010, Biomaterials.

[50]  A. Stefanović,et al.  HDL 2 particles are associated with hyperglycaemia, lower PON1 activity and oxidative stress in type 2 diabetes mellitus patients. , 2010, Clinical biochemistry.

[51]  Lisa Brannon-Peppas,et al.  Preparation and initial characterization of biodegradable particles containing gadolinium-DTPA contrast agent for enhanced MRI , 2008, Proceedings of the National Academy of Sciences.

[52]  Tae-Jong Yoon,et al.  Toxicity and tissue distribution of magnetic nanoparticles in mice. , 2006, Toxicological sciences : an official journal of the Society of Toxicology.

[53]  Sara Linse,et al.  Detailed identification of plasma proteins adsorbed on copolymer nanoparticles. , 2007, Angewandte Chemie.

[54]  Wolfgang Kreyling,et al.  Ultrafine Particles Cross Cellular Membranes by Nonphagocytic Mechanisms in Lungs and in Cultured Cells , 2005, Environmental health perspectives.

[55]  C. Bode,et al.  Superparamagnetic iron oxide binding and uptake as imaged by magnetic resonance is mediated by the integrin receptor Mac-1 (CD11b/CD18): implications on imaging of atherosclerotic plaques. , 2007, Atherosclerosis.

[56]  C. Tros de Ilarduya,et al.  Pharmacodynamics of cisplatin-loaded PLGA nanoparticles administered to tumor-bearing mice. , 2010, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[57]  S M Moghimi,et al.  Long-circulating and target-specific nanoparticles: theory to practice. , 2001, Pharmacological reviews.

[58]  P. Stroeve,et al.  Templated growth of superparamagnetic iron oxide nanoparticles by temperature programming in the presence of poly(vinyl alcohol) , 2010 .

[59]  Su Jin Kang,et al.  Titanium dioxide nanoparticles trigger p53‐mediated damage response in peripheral blood lymphocytes , 2008, Environmental and molecular mutagenesis.

[60]  E. Cadenas.  Mitochondrial free radical production and cell signaling. , 2004, Molecular aspects of medicine.

[61]  Lawrence E Murr,et al.  Comparative in vitro cytotoxicity assessment of some manufacturednanoparticulate materials characterized by transmissionelectron microscopy , 2005 .

[62]  Jie Chen,et al.  Gold nanoparticle sensitize radiotherapy of prostate cancer cells by regulation of the cell cycle , 2009, Nanotechnology.

[63]  B. Kim,et al.  Titanium dioxide nanoparticles induce apoptosis through the JNK/p38-caspase-8-Bid pathway in phytohemagglutinin-stimulated human lymphocytes. , 2009, Biochemical and biophysical research communications.

[64]  Jeff W M Bulte,et al.  Feridex labeling of mesenchymal stem cells inhibits chondrogenesis but not adipogenesis or osteogenesis , 2004, NMR in biomedicine.

[65]  Julie W. Fitzpatrick,et al.  Principles for characterizing the potential human health effects from exposure to nanomaterials: elements of a screening strategy , 2005, Particle and Fibre Toxicology.

[66]  Elizabeth C. Theil,et al.  Ferritins: iron/oxygen biominerals in protein nanocages , 2006, JBIC Journal of Biological Inorganic Chemistry.

[67]  M. Yacamán,et al.  The bactericidal effect of silver nanoparticles , 2005, Nanotechnology.

[68]  E. Ogier-Denis,et al.  Diesel exhaust particles induce matrix metalloprotease-1 in human lung epithelial cells via a NADP(H) oxidase/NOX4 redox-dependent mechanism. , 2007, American journal of physiology. Lung cellular and molecular physiology.

[69]  Ralph Weissleder,et al.  Differential conjugation of tat peptide to superparamagnetic nanoparticles and its effect on cellular uptake. , 2002, Bioconjugate chemistry.

[70]  A. Ivask,et al.  Profiling of the reactive oxygen species-related ecotoxicity of CuO, ZnO, TiO2, silver and fullerene nanoparticles using a set of recombinant luminescent Escherichia coli strains: differentiating the impact of particles and solubilised metals , 2010, Analytical and bioanalytical chemistry.

[71]  Simon Benita,et al.  Targeting of nanoparticles to the clathrin-mediated endocytic pathway. , 2007, Biochemical and biophysical research communications.

[72]  G. Prindull.  Final checkup of neoplastic DNA replication: evidence for failure in decision-making at the mitotic cell cycle checkpoint G(1)/S. , 2008, Experimental hematology.

[73]  L. Forró,et al.  Cellular toxicity of carbon-based nanomaterials. , 2006, Nano letters.

[74]  M. Mahmoudi,et al.  Cytotoxicity of Uncoated and Polyvinyl Alcohol Coated Superparamagnetic Iron Oxide Nanoparticles , 2009 .

[75]  J F Leary,et al.  Doublet discrimination in DNA cell-cycle analysis. , 2001, Cytometry.

[76]  A. Pollack,et al.  Simultaneous estimation of T(G2+M), T(S), and T(pot) using single sample dynamic tumor data from bivariate DNA-thymidine analogue cytometry. , 2000, Cytometry.

[77]  Chung-Yuan Mou,et al.  Bifunctional magnetic silica nanoparticles for highly efficient human stem cell labeling. , 2007, Nano letters.

[78]  Ralph Weissleder,et al.  Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells , 2000, Nature Biotechnology.

[79]  J. Gillard,et al.  Atorvastatin and uptake of ultrasmall superparamagnetic iron oxide nanoparticles (Ferumoxtran-10) in human monocyte-macrophages: implications for magnetic resonance imaging. , 2008, Biomaterials.

[80]  M. Mahmoudi,et al.  Recent advances in surface engineering of superparamagnetic iron oxide nanoparticles for biomedical applications , 2010 .

[81]  Suresh Valiyaveettil,et al.  DNA damage and p53-mediated growth arrest in human cells treated with platinum nanoparticles. , 2010, Nanomedicine.

[82]  J. Smith,et al.  Do cells cycle? , 1973, Proceedings of the National Academy of Sciences of the United States of America.

[83]  T. Xia,et al.  Understanding biophysicochemical interactions at the nano-bio interface. , 2009, Nature materials.

[84]  Ming Wang,et al.  Mechanisms of unmodified CdSe quantum dot-induced elevation of cytoplasmic calcium levels in primary cultures of rat hippocampal neurons. , 2008, Biomaterials.

[85]  A. Curtis,et al.  Receptor-mediated targeting of magnetic nanoparticles using insulin as a surface ligand to prevent endocytosis , 2003, IEEE Transactions on NanoBioscience.

[86]  B. Van Houten,et al.  Role of mitochondrial DNA in toxic responses to oxidative stress. , 2006, DNA repair.

[87]  M. Barbacid,et al.  Cell cycle, CDKs and cancer: a changing paradigm , 2009, Nature Reviews Cancer.

[88]  A. Curtis,et al.  Dextran and albumin derivatised iron oxide nanoparticles: influence on fibroblasts in vitro. , 2003, Biomaterials.

[89]  C. Parish,et al.  Monitoring lymphocyte proliferation in vitro and in vivo with the intracellular fluorescent dye carboxyfluorescein diacetate succinimidyl ester , 2007, Nature Protocols.

[90]  P. Morais,et al.  Toxic effects of ionic magnetic fluids in mice , 1999 .

[91]  David Kirkland,et al.  Clastogenicity, photo-clastogenicity or pseudo-photo-clastogenicity: Genotoxic effects of zinc oxide in the dark, in pre-irradiated or simultaneously irradiated Chinese hamster ovary cells. , 2006, Mutation research.

[92]  Toshiyuki Saito,et al.  DNA damage-dependent cell cycle checkpoints and genomic stability. , 2006, DNA and cell biology.

[93]  Mingqiang Zhu,et al.  Heparin-paclitaxel conjugates as drug delivery system: synthesis, self-assembly property, drug release, and antitumor activity. , 2009, Bioconjugate chemistry.

[94]  Steffen Loft,et al.  Oxidative stress-induced DNA damage by particulate air pollution. , 2005, Mutation research.

[95]  Fiona Wood,et al.  Nanocrystalline silver dressings in wound management: a review , 2006, International journal of nanomedicine.

[96]  L. J. Lee,et al.  Cationic lipid-coated magnetic nanoparticles associated with transferrin for gene delivery. , 2008, International journal of pharmaceutics.

[97]  Z. Darżynkiewicz,et al.  Simultaneous analysis of cell cycle kinetics at two different DNA ploidy levels based on DNA content and cyclin B measurements. , 1993, Cancer research.

[98]  Abraham Ulman,et al.  Adverse effects of citrate/gold nanoparticles on human dermal fibroblasts. , 2006, Small.

[99]  Zbigniew Darzynkiewicz,et al.  Cytometry of the cell cycle: Cycling through history , 2004, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

[100]  W. Xiao,et al.  DNA Damage Checkpoints Are Involved in Postreplication Repair , 2006, Genetics.

[101]  H. Moon,et al.  PEGylated conjugated linoleic acid stimulation of apoptosis via a p53-mediated signaling pathway in MCF-7 breast cancer cells. , 2008, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[102]  James R Baker,et al.  Understanding specific and nonspecific toxicities: a requirement for the development of dendrimer-based pharmaceuticals. , 2010, Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology.

[103]  D. Rouch,et al.  Understanding cellular responses to toxic agents: a model for mechanism-choice in bacterial metal resistance , 1995, Journal of Industrial Microbiology.

[104]  S. Cooper,et al.  Rethinking synchronization of mammalian cells for cell cycle analysis , 2003, Cellular and Molecular Life Sciences CMLS.

[105]  J. Kirschvink,et al.  Magnetite in human tissues: a mechanism for the biological effects of weak ELF magnetic fields. , 1992, Bioelectromagnetics.

[106]  Ajay Kumar Gupta,et al.  Cytotoxicity suppression and cellular uptake enhancement of surface modified magnetic nanoparticles. , 2005, Biomaterials.

[107]  Gert Storm,et al.  Surface modification of nanoparticles to oppose uptake by the mononuclear phagocyte system , 1995 .

[108]  R Weissleder,et al.  Superparamagnetic iron oxide: pharmacokinetics and toxicity. , 1989, AJR. American journal of roentgenology.

[109]  David B Warheit,et al.  Assessing toxicity of fine and nanoparticles: comparing in vitro measurements to in vivo pulmonary toxicity profiles. , 2007, Toxicological sciences : an official journal of the Society of Toxicology.

[110]  Scott T. Clarke,et al.  Detection of S-phase cell cycle progression using 5-ethynyl-2'-deoxyuridine incorporation with click chemistry, an alternative to using 5-bromo-2'-deoxyuridine antibodies. , 2008, BioTechniques.

[111]  Corie Lok.  Alan Hall, chairman, cell biology programme, Memorial Sloan-Kettering Cancer Center, New York , 2006 .

[112]  S. Sahoo,et al.  Intracellular trafficking of nuclear localization signal conjugated nanoparticles for cancer therapy. , 2010, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[113]  Clinton F Jones,et al.  In vitro assessments of nanomaterial toxicity. , 2009, Advanced drug delivery reviews.

[114]  M. Roberts,et al.  Grey Goo on the Skin? Nanotechnology, Cosmetic and Sunscreen Safety , 2007, Critical reviews in toxicology.

[115]  Matthew J Dalby,et al.  The influence of transferrin stabilised magnetic nanoparticles on human dermal fibroblasts in culture. , 2004, International journal of pharmaceutics.

[116]  D. Maysinger,et al.  Micellar Nanocontainers Distribute to Defined Cytoplasmic Organelles , 2003, Science.

[117]  J. Schlager,et al.  DNA damage response to different surface chemistry of silver nanoparticles in mammalian cells. , 2008, Toxicology and applied pharmacology.

[118]  Rafael Núñez,et al.  DNA measurement and cell cycle analysis by flow cytometry. , 2001, Current issues in molecular biology.

[119]  P. Hoet,et al.  Nanoparticles – known and unknown health risks , 2004, Journal of nanobiotechnology.

[120]  Isabelle Raynal,et al.  Macrophage Endocytosis of Superparamagnetic Iron Oxide Nanoparticles: Mechanisms and Comparison of Ferumoxides and Ferumoxtran-10 , 2004, Investigative radiology.

[121]  D. Leslie-Pelecky,et al.  Biodistribution, clearance, and biocompatibility of iron oxide magnetic nanoparticles in rats. , 2008, Molecular pharmaceutics.

[122]  Michael N Helmus.  From the lab to the market. , 2007, Nature nanotechnology.

[123]  Shiladitya Sengupta,et al.  Fullerenol-cytotoxic conjugates for cancer chemotherapy. , 2009, ACS nano.

[124]  J. Lysiak,et al.  Oxidative stress: a common factor in testicular dysfunction. , 2008, Journal of andrology.

[125]  H. Karlsson,et al.  Copper oxide nanoparticles are highly toxic: a comparison between metal oxide nanoparticles and carbon nanotubes. , 2008, Chemical research in toxicology.

[126]  Timothy J. Mitchison,et al.  A chemical method for fast and sensitive detection of DNA synthesis in vivo , 2008, Proceedings of the National Academy of Sciences.

[127]  Feng Gao,et al.  Oxidative stress contributes to silica nanoparticle-induced cytotoxicity in human embryonic kidney cells. , 2009, Toxicology in vitro : an international journal published in association with BIBRA.

[128]  Philippe Robert,et al.  Recent advances in iron oxide nanocrystal technology for medical imaging. , 2006, Advanced drug delivery reviews.

[129]  George M Whitesides,et al.  Nanoscience, nanotechnology, and chemistry. , 2005, Small.

[130]  M. Melamed,et al.  Laser-scanning cytometry: A new instrumentation with many applications. , 1999, Experimental cell research.

[131]  T. Hei,et al.  Genotoxic responses to titanium dioxide nanoparticles and fullerene in gpt delta transgenic MEF cells , 2009, Particle and Fibre Toxicology.

[132]  Paolo Ubezio,et al.  Interpreting cell cycle effects of drugs: the case of melphalan , 2006, Cancer Chemotherapy and Pharmacology.

[133]  M. Goicochea,et al.  Oxidative stress and inflammation, a link between chronic kidney disease and cardiovascular disease. , 2008, Kidney international. Supplement.

[134]  E. Korn,et al.  PHAGOCYTOSIS OF LATEX BEADS BY ACANTHAMOEBA , 1967, The Journal of cell biology.

[135]  P. Morais,et al.  Morphological analysis of mouse lungs after treatment with magnetite-based magnetic fluid stabilized with DMSA , 2005 .

[136]  Paul K Wallace,et al.  Cell Tracking 2007: A Proliferation of Probes and Applications , 2007, Immunological investigations.

[137]  A. Curtis,et al.  Cell response to dextran-derivatised iron oxide nanoparticles post internalisation. , 2004, Biomaterials.

[138]  V. Torchilin,et al.  Biodegradable long-circulating polymeric nanospheres. , 1994, Science.

[139]  A. Weiss,et al.  Influence of CR3 (CD11b/CD18) Expression on Phagocytosis of Bordetella pertussis by Human Neutrophils , 2005, Infection and Immunity.

[140]  Jenny R. Roberts,et al.  Skin as a route of exposure and sensitization in chronic beryllium disease. , 2003, Environmental health perspectives.

[141]  Yin-Kai Chen,et al.  The promotion of human mesenchymal stem cell proliferation by superparamagnetic iron oxide nanoparticles. , 2009, Biomaterials.

[142]  Morteza Mahmoudi,et al.  A new approach for the in vitro identification of the cytotoxicity of superparamagnetic iron oxide nanoparticles. , 2010, Colloids and surfaces. B, Biointerfaces.

[143]  K. Shedden,et al.  Analysis of cell-cycle-specific gene expression in human cells as determined by microarrays and double-thymidine block synchronization , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[144]  B. Jiang,et al.  Size-dependent effects of tungsten carbide-cobalt particles on oxygen radical production and activation of cell signaling pathways in murine epidermal cells. , 2009, Toxicology and applied pharmacology.

[145]  H. Vali,et al.  Cytotoxicity and Cell Cycle Effects of Bare and Poly(vinyl alcohol)‐Coated Iron Oxide Nanoparticles in Mouse Fibroblasts , 2009 .

[146]  Morteza Mahmoudi,et al.  Optimal design and characterization of superparamagnetic iron oxide nanoparticles coated with polyvinyl alcohol for targeted delivery and imaging. , 2008, The journal of physical chemistry. B.

[147]  A. Tsourkas,et al.  Size, charge and concentration dependent uptake of iron oxide particles by non-phagocytic cells. , 2008, Biomaterials.

[148]  K. Jan,et al.  Ultrafine titanium dioxide particles in the absence of photoactivation can induce oxidative damage to human bronchial epithelial cells. , 2005, Toxicology.

[149]  Mark R Wiesner,et al.  Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm. , 2006, Nano letters.

[150]  S. Tsuji,et al.  Enhancement of macrophage phagocytosis upon iC3b deposition on apoptotic cells , 1996, FEBS letters.

[151]  S. Pervaiz,et al.  Automated laser scanning cytometry: A powerful tool for multi‐parameter analysis of drug‐induced apoptosis , 2007, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

[152]  E. Amaro,et al.  Kinetics of elimination and distribution in blood and liver of biocompatible ferrofluids based on Fe3O4 nanoparticles: An EPR and XRF study , 2008 .

[153]  Morteza Mahmoudi,et al.  An in vitro study of bare and poly(ethylene glycol)-co-fumarate-coated superparamagnetic iron oxide nanoparticles: a new toxicity identification procedure , 2009, Nanotechnology.

[154]  H. Shapiro,et al.  The evolution of cytometers , 2004, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

[155]  K. Kishi,et al.  Profile of cell cycle in hematopoietic malignancy by DNA/RNA quantitation using 7AAD/PY. , 1996, Experimental hematology.

[156]  Jean-Luc Coll,et al.  Targeting cyclin B1 through peptide-based delivery of siRNA prevents tumour growth , 2009, Nucleic acids research.

[157]  Miqin Zhang,et al.  Methotrexate-modified superparamagnetic nanoparticles and their intracellular uptake into human cancer cells. , 2005, Langmuir : the ACS journal of surfaces and colloids.

[158]  M Laird Forrest,et al.  Effects of nanomaterial physicochemical properties on in vivo toxicity. , 2009, Advanced drug delivery reviews.

[159]  W. Rogers,et al.  Factors regulating macrophage endocytosis of nanoparticles: implications for targeted magnetic resonance plaque imaging. , 2005, Atherosclerosis.

[160]  Evaluation of multi-organ DNA damage by comet assay from 28 days repeated dose oral toxicity test in mice: a practical approach for test integration in regulatory toxicity testing. , 2010, Regulatory toxicology and pharmacology : RTP.

[161]  J. Larsen,et al.  Detection of proliferating cell nuclear antigen. , 2001, Methods in cell biology.

[162]  L. Venema.  Nanoscience: Small talk , 2006, Nature.

[163]  Ashley I Bush,et al.  Metals in Alzheimer's and Parkinson's diseases. , 2008, Current opinion in chemical biology.

[164]  Jerry S. H. Lee,et al.  Magnetic nanoparticles in MR imaging and drug delivery. , 2008, Advanced drug delivery reviews.

[165]  A. Seifalian,et al.  Properties Evaluation of a New MRI Contrast Agent Based on Gd-Loaded Nanoparticles , 2010, Biological Trace Element Research.

[166]  P. Morais,et al.  In vitro biological activities of anionic gamma-Fe2O3 nanoparticles on human melanoma cells. , 2008, Journal of nanoscience and nanotechnology.

[167]  D. Astruc,et al.  Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology. , 2004, Chemical reviews.

[168]  Nathan Kohler,et al.  Surface modification of superparamagnetic magnetite nanoparticles and their intracellular uptake. , 2002, Biomaterials.

[169]  M. Hande,et al.  Cytotoxicity and genotoxicity of silver nanoparticles in human cells. , 2009, ACS nano.

[170]  A. Curtis,et al.  Lactoferrin and ceruloplasmin derivatized superparamagnetic iron oxide nanoparticles for targeting cell surface receptors. , 2004, Biomaterials.

[171]  V. Shastri,et al.  The effect of silica nanoparticle-modified surfaces on cell morphology, cytoskeletal organization and function. , 2008, Biomaterials.

[172]  Bernadette Bensaude-Vincent,et al.  Materials science: a field about to explode? , 2004, Nature Materials.

[173]  Christian Joachim,et al.  To be nano or not to be nano? , 2005, Nature materials.

[174]  R. L. Jones,et al.  Unique cellular interaction of silver nanoparticles: size-dependent generation of reactive oxygen species. , 2008, The journal of physical chemistry. B.

[175]  Tung-Sheng Shih,et al.  Disturbed mitotic progression and genome segregation are involved in cell transformation mediated by nano-TiO2 long-term exposure. , 2009, Toxicology and applied pharmacology.

[176]  J. Joh,et al.  Characterization, in vitro cytotoxicity assessment, and in vivo visualization of multimodal, RITC-labeled, silica-coated magnetic nanoparticles for labeling human cord blood-derived mesenchymal stem cells. , 2010, Nanomedicine : nanotechnology, biology, and medicine.

[177]  A. Nel,et al.  Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage. , 2002, Environmental health perspectives.

[178]  L. Murr,et al.  Cytotoxic effects of aggregated nanomaterials. , 2007, Acta biomaterialia.

[179]  J. Rosenecker,et al.  Insights into the mechanism of magnetofection using PEI‐based magnetofectins for gene transfer , 2004, The journal of gene medicine.

[180]  C. Robic,et al.  Magnetic iron oxide nanoparticles: synthesis, stabilization, vectorization, physicochemical characterizations, and biological applications. , 2008, Chemical reviews.

[181]  J. Carter,et al.  Metals associated with both the water-soluble and insoluble fractions of an ambient air pollution particle catalyze an oxidative stress. , 1999, Inhalation toxicology.

[182]  J. Connor,et al.  Ferritin: a novel mechanism for delivery of iron to the brain and other organs. , 2007, American journal of physiology. Cell physiology.

[183]  Warren C W Chan,et al.  Elucidating the mechanism of cellular uptake and removal of protein-coated gold nanoparticles of different sizes and shapes. , 2007, Nano letters.

[184]  S. Maiti,et al.  Dendritic effect of ligand-coated nanoparticles: enhanced apoptotic activity of silica-berberine nanoconjugates. , 2009, Langmuir : the ACS journal of surfaces and colloids.

[185]  A. Rees,et al.  Peptide delivery to the brain via adsorptive-mediated endocytosis: Advances with SynB vectors , 2002, AAPS PharmSci.

[186]  P. Morais,et al.  Biological effects of magnetic fluids: toxicity studies , 1999 .

[187]  V. Ganapathy,et al.  Functional coupling between a bafilomycin A1-sensitive proton pump and a probenecid-sensitive folate transporter in human placental choriocarcinoma cells. , 1994, Biochimica et biophysica acta.

[188]  P. Kesharwani,et al.  Dendrimer toxicity: Let's meet the challenge. , 2010, International journal of pharmaceutics.

[189]  N. Dhalla,et al.  Role of oxidative stress in cardiovascular diseases , 2000, Journal of hypertension.

[190]  Paula M Jacobs,et al.  Preclinical Safety and Pharmacokinetic Profile of Ferumoxtran-10, an Ultrasmall Superparamagnetic Iron Oxide Magnetic Resonance Contrast Agent , 2006, Investigative radiology.

[191]  Lili He,et al.  In vitro evaluation of the genotoxicity of a family of novel MeO-PEG-poly(D,L-lactic-co-glycolic acid)-PEG-OMe triblock copolymer and PLGA nanoparticles , 2009, Nanotechnology.

[192]  Florence Gazeau,et al.  Universal cell labelling with anionic magnetic nanoparticles. , 2008, Biomaterials.

[193]  Y. Dupertuis,et al.  A pitfall of propidium iodide staining in fluorescence-activated cell sorting cell cycle analysis? , 2007, Cancer research.

[194]  M. Block,et al.  Microglia-mediated neurotoxicity: uncovering the molecular mechanisms , 2007, Nature Reviews Neuroscience.

[195]  E. Nigg,et al.  Cyclin‐dependent protein kinases: Key regulators of the eukaryotic cell cycle , 1995, BioEssays : news and reviews in molecular, cellular and developmental biology.

[196]  S. Gordon,et al.  Scavenger receptors in innate immunity. , 2002, Current opinion in immunology.

[197]  W. Chan,et al.  Nanotoxicity: the growing need for in vivo study. , 2007, Current opinion in biotechnology.

[198]  S. Soenen,et al.  Addressing the problem of cationic lipid-mediated toxicity: the magnetoliposome model. , 2009, Biomaterials.

[199]  Catrin Albrecht,et al.  Cellular responses to nanoparticles: Target structures and mechanisms , 2007 .

[200]  T. Waseem,et al.  Ferritin, a protein containing iron nanoparticles, induces reactive oxygen species formation and inhibits glutamate uptake in rat brain synaptosomes , 2008, Brain Research.

[201]  J. Audet,et al.  High-resolution tracking of cell division suggests similar cell cycle kinetics of hematopoietic stem cells stimulated in vitro and in vivo. , 2000, Blood.

[202]  Zi-rong Xu,et al.  In vitro effects of chitosan nanoparticles on proliferation of human gastric carcinoma cell line MGC803 cells. , 2005, World journal of gastroenterology.

[203]  M. E. Kooi,et al.  Accumulation of Ultrasmall Superparamagnetic Particles of Iron Oxide in Human Atherosclerotic Plaques Can Be Detected by In Vivo Magnetic Resonance Imaging , 2003, Circulation.

[204]  T. Xia,et al.  Toxic Potential of Materials at the Nanolevel , 2006, Science.

[205]  P. Walczak,et al.  Applicability and limitations of MR tracking of neural stem cells with asymmetric cell division and rapid turnover: The case of the Shiverer dysmyelinated mouse brain , 2007, Magnetic resonance in medicine.

[206]  M. Mahmoudi,et al.  Superparamagnetic Iron Oxide Nanoparticles with Rigid Cross-linked Polyethylene Glycol Fumarate Coating for Application in Imaging and Drug Delivery , 2009 .

[207]  A. Torricelli,et al.  From flow cytometric BrdUrd data to cell population growth and doubling time. , 1997, Cytometry.

[208]  G. Li,et al.  Nanometer size diesel exhaust particles are selectively toxic to dopaminergic neurons: the role of microglia, phagocytosis, and NADPH oxidase , 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[209]  Patrick A. Cooke,et al.  Molecular Characterization of the Cytotoxic Mechanism of Multiwall Carbon Nanotubes and Nano-onions on Human Skin Fibroblast , 2005 .

[210]  F. Bonomini,et al.  Atherosclerosis and oxidative stress. , 2008, Histology and histopathology.

[211]  Michael Aschner,et al.  Effects of Nanoparticles on the Adhesion and Cell Viability on Astrocytes , 2007, Biological Trace Element Research.

[212]  D. Begley.  Delivery of therapeutic agents to the central nervous system: the problems and the possibilities. , 2004, Pharmacology & therapeutics.

[213]  P Stroeve,et al.  Cell toxicity of superparamagnetic iron oxide nanoparticles. , 2009, Journal of colloid and interface science.

[214]  J. Debatin,et al.  Magnetic Resonance Imaging of Atherosclerotic Plaque With Ultrasmall Superparamagnetic Particles of Iron Oxide in Hyperlipidemic Rabbits , 2001, Circulation.

[215]  Qamar Rahman,et al.  Evidence that ultrafine titanium dioxide induces micronuclei and apoptosis in Syrian hamster embryo fibroblasts. , 2002, Environmental health perspectives.

[216]  Michael P. Murphy,et al.  How mitochondria produce reactive oxygen species , 2008, The Biochemical journal.

[217]  N. Monteiro-Riviere,et al.  Penetration of intact skin by quantum dots with diverse physicochemical properties. , 2006, Toxicological sciences : an official journal of the Society of Toxicology.

[218]  A. B. Lyons,et al.  Analysing cell division in vivo and in vitro using flow cytometric measurement of CFSE dye dilution. , 2000, Journal of immunological methods.

[219]  Jeff W. M. Bulte.  Magnetic nanoparticles as markers for cellular MR imaging , 2005 .

[220]  R. Müller,et al.  Cytotoxicity of magnetite-loaded polylactide, polylactide/glycolide particles and solid lipid nanoparticles , 1996 .

[221]  H Stein,et al.  Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. , 1984, Journal of immunology.

[222]  S. Dowdy,et al.  TAT transduction: the molecular mechanism and therapeutic prospects. , 2007, Trends in molecular medicine.

[223]  Navid B. Saleh,et al.  Titanium dioxide (P25) produces reactive oxygen species in immortalized brain microglia (BV2): implications for nanoparticle neurotoxicity. , 2006, Environmental science & technology.

[224]  J. Bacri,et al.  Intracellular uptake of anionic superparamagnetic nanoparticles as a function of their surface coating. , 2003, Biomaterials.

[225]  N. Simionescu,et al.  Anionized and cationized hemeundecapeptides as probes for cell surface charge and permeability studies: differentiated labeling of endothelial plasmalemmal vesicles , 1985, The Journal of cell biology.

[226]  Tian Xia,et al.  The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles. , 2008, Free radical biology & medicine.

[227]  T. Kelly,et al.  Postreplication gaps at UV lesions are signals for checkpoint activation , 2010, Proceedings of the National Academy of Sciences.

[228]  Sara Linse,et al.  The nanoparticle-protein complex as a biological entity; a complex fluids and surface science challenge for the 21st century. , 2007, Advances in colloid and interface science.

[229]  Abbas S. Milani,et al.  Multiphysics Flow Modeling and in Vitro Toxicity of Iron Oxide Nanoparticles Coated with Poly(vinyl alcohol) , 2009 .

[230]  Hui Li,et al.  Nanoparticle-driven DNA damage mimics irradiation-related carcinogenesis pathways , 2008, European Respiratory Journal.

[231]  Maria Jose Alonso,et al.  Chitosan-based nanostructures: a delivery platform for ocular therapeutics. , 2010, Advanced drug delivery reviews.

[232]  Nastassja A. Lewinski,et al.  Cytotoxicity of nanoparticles. , 2008, Small.

[233]  Yu Zhang,et al.  Intrinsic peroxidase-like activity of ferromagnetic nanoparticles. , 2007, Nature nanotechnology.

[234]  M. Mahmoudi,et al.  Superparamagnetic iron oxide nanoparticles (SPIONs): development, surface modification and applications in chemotherapy. , 2011, Advanced drug delivery reviews.

[235]  Zhigang Wang,et al.  Gd-DTPA-loaded PLGA microbubbles as both ultrasound contrast agent and MRI contrast agent--a feasibility research. , 2010, Journal of biomedical materials research. Part B, Applied biomaterials.