Plasmapheresis as an adjunct to management of Rh isoimmunization.

Plasmapheresis as therapy for Rh isoimmunization has gained recent attention in Great Britain; however, this technique has not been widely accepted in the United States. At Wilford Hall USAF Medical Center, separator was beneficial in the management of a patient with Rh isoimmunization. A decrease in the delta optical density (OD) 450 followed the onset of plasmapheresis by 3 and 4 weeks and a correlation between the plasma anti-D concentration and the severity of the delta OD 450 was demonstrated.