The TLK1-Nek1 axis promotes prostate cancer progression.

[1]  A. De Benedetti,et al.  Targeting the TLK1/NEK1 DDR axis with Thioridazine suppresses outgrowth of androgen independent prostate tumors , 2019, International journal of cancer.

[2]  Camille Stephan-Otto Attolini,et al.  Tousled-like kinases stabilize replication forks and show synthetic lethality with checkpoint and PARP inhibitors , 2018, Science Advances.

[3]  G. Sunavala-Dossabhoy.  Preserving salivary gland physiology against genotoxic damage - the Tousled way. , 2018, Oral diseases.

[4]  A. De Benedetti,et al.  Identification of the proteome complement of humanTLK1 reveals it binds and phosphorylates NEK1 regulating its activity , 2017, Cell cycle.

[5]  Annelot M. Dekker,et al.  NEK1 variants confer susceptibility to amyotrophic lateral sclerosis , 2016, Nature Genetics.

[6]  Olivia Barton,et al.  Nek1 Regulates Rad54 to Orchestrate Homologous Recombination and Replication Fork Stability. , 2016, Molecular cell.

[7]  N. Sonenberg,et al.  Targeting the translation machinery in cancer , 2015, Nature Reviews Drug Discovery.

[8]  J. Kobarg,et al.  New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing , 2015, Proteome Science.

[9]  N. Sonenberg,et al.  Targeting the eIF4F translation initiation complex: a critical nexus for cancer development. , 2015, Cancer research.

[10]  Zhongming Zhao,et al.  Key regulators in prostate cancer identified by co-expression module analysis , 2014, BMC Genomics.

[11]  J. Kobarg,et al.  "Stop Ne(c)king around": How interactomics contributes to functionally characterize Nek family kinases. , 2014, World journal of biological chemistry.

[12]  L. Zou,et al.  Nek1 kinase associates with ATR–ATRIP and primes ATR for efficient DNA damage signaling , 2013, Proceedings of the National Academy of Sciences.

[13]  A. Benedetti.  The Tousled-Like Kinases as Guardians of Genome Integrity , 2012 .

[14]  A. De Benedetti,et al.  The expression of tousled kinases in CaP cell lines and its relation to radiation response and DSB repair , 2011, The Prostate.

[15]  Sarat Chandarlapaty,et al.  Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer. , 2011, Cancer cell.

[16]  D. Riley,et al.  Nek1 kinase functions in DNA damage response and checkpoint control through a pathway independent of ATM and ATR , 2011, Cell cycle.

[17]  Huai-Chin Chiang,et al.  Mutation of NIMA-related kinase 1 (NEK1) leads to chromosome instability , 2011, Molecular Cancer.

[18]  D. Moura,et al.  Nek1 silencing slows down DNA repair and blocks DNA damage-induced cell cycle arrest. , 2010, Mutagenesis.

[19]  D. Riley,et al.  Never-in-mitosis related Kinase 1 functions in DNA damage response and checkpoint control , 2008, Cell cycle.

[20]  C. Meschonat,et al.  Correlation of TLK1B in elevation and recurrence in doxorubicin-treated breast cancer patients with high eIF4E overexpression. , 2007, Journal of the American College of Surgeons.

[21]  J. Graff,et al.  eIF-4E expression and its role in malignancies and metastases , 2004, Oncogene.

[22]  A. De Benedetti,et al.  Translation of the radioresistance kinase TLK1B is induced by γ-irradiation through activation of mTOR and phosphorylation of 4E-BP1 , 2004, BMC Molecular Biology.

[23]  A. Benedetti,et al.  A translationally regulated Tousled kinase phosphorylates histone H3 and confers radioresistance when overexpressed , 2001, Oncogene.

[24]  E. Birkenmeier,et al.  Mutations in a NIMA-related kinase gene, Nek1, cause pleiotropic effects including a progressive polycystic kidney disease in mice. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[25]  A. De Benedetti,et al.  Elevated expression of eIF4E in confined early breast cancer lesions: Possible role of hypoxia , 1999, International journal of cancer.

[26]  M. Kattan,et al.  Androgen-independent prostate cancer progression in the TRAMP model. , 1997, Cancer research.

[27]  J. Rosen,et al.  Metastatic prostate cancer in a transgenic mouse. , 1996, Cancer research.

[28]  S. Osmani,et al.  Mitotic induction and maintenance by overexpression of a G2-specific gene that encodes a potential protein kinase , 1988, Cell.

[29]  J. Mathis,et al.  Phenothiazine Inhibitors of TLKs Affect Double-Strand Break Repair and DNA Damage Response Recovery and Potentiate Tumor Killing with Radiomimetic Therapy. , 2013, Genes & cancer.