Cerebrospinal fluid concentration of complement component 4A is increased in first episode schizophrenia

[1]  A. Zalesky,et al.  Increased peripheral inflammation in schizophrenia is associated with worse cognitive performance and related cortical thickness reductions , 2021, European Archives of Psychiatry and Clinical Neuroscience.

[2]  S. Erhardt,et al.  Disrupted sensorimotor gating in first-episode psychosis patients is not affected by short-term antipsychotic treatment , 2021, Schizophrenia Research.

[3]  K. Blennow,et al.  Cerebrospinal fluid biomarker panel for synaptic dysfunction in Alzheimer's disease , 2021, Alzheimer's & dementia.

[4]  Christopher W. Whelan,et al.  Overexpression of schizophrenia susceptibility factor human complement C4A promotes excessive synaptic loss and behavioral changes in mice , 2020, Nature Neuroscience.

[5]  M. Leboyer,et al.  Elevated expression of complement C4 in the mouse prefrontal cortex causes schizophrenia-associated phenotypes , 2020, bioRxiv.

[6]  A. Malhotra,et al.  Complement component C4 levels in the cerebrospinal fluid and plasma of patients with schizophrenia , 2020, Neuropsychopharmacology.

[7]  S. Djurovic,et al.  Association between complement component 4A expression, cognitive performance and brain imaging measures in UK Biobank , 2020, Psychological Medicine.

[8]  P. Worley,et al.  Neuronal pentraxin 2: a synapse-derived CSF biomarker in genetic frontotemporal dementia , 2020, Journal of Neurology, Neurosurgery, and Psychiatry.

[9]  Qijing Bo,et al.  Higher Serum C-Reactive Protein Levels in Catatonic Patients: A Comparison to Non-catatonic Patients and Healthy Controls. , 2020, Schizophrenia bulletin.

[10]  L. Perez-Cano,et al.  Brain gene co-expression networks link complement signaling with convergent synaptic pathology in schizophrenia , 2020, Nature Neuroscience.

[11]  M. D. Forti,et al.  Baseline high levels of complement component 4 predict worse clinical outcome at 1-year follow-up in first-episode psychosis , 2020, Brain, Behavior, and Immunity.

[12]  O. Howes,et al.  Synaptic density marker SV2A is reduced in schizophrenia patients and unaffected by antipsychotics in rats , 2020, Nature Communications.

[13]  R. Kahn,et al.  Synapse Pathology in Schizophrenia: A Meta-analysis of Postsynaptic Elements in Postmortem Brain Studies , 2019, Schizophrenia bulletin.

[14]  R. Perlis,et al.  Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning , 2019, Nature Neuroscience.

[15]  R. Lenroot,et al.  C-Reactive Protein: Higher During Acute Psychotic Episodes and Related to Cortical Thickness in Schizophrenia and Healthy Controls , 2018, Front. Immunol..

[16]  A. Malhotra,et al.  Cytokines in cerebrospinal fluid of patients with schizophrenia spectrum disorders: New data and an updated meta-analysis , 2018, Schizophrenia Research.

[17]  Rajiv P. Sharma,et al.  C4A mRNA expression in PBMCs predicts the presence and severity of delusions in schizophrenia and bipolar disorder with psychosis , 2018, Schizophrenia Research.

[18]  M. Gill,et al.  Genetically predicted complement component 4A expression: effects on memory function and middle temporal lobe activation , 2018, Psychological Medicine.

[19]  R. Murray,et al.  Remission and recovery from first-episode psychosis in adults: systematic review and meta-analysis of long-term outcome studies , 2017, British Journal of Psychiatry.

[20]  R. Murray,et al.  Complement system biomarkers in first episode psychosis , 2017, Schizophrenia Research.

[21]  K. Roy,et al.  Habituation based synaptic plasticity and organismic learning in a quantum perovskite , 2017, Nature Communications.

[22]  P. O’Reilly,et al.  An Examination of Polygenic Score Risk Prediction in Individuals With First-Episode Psychosis , 2017, Biological Psychiatry.

[23]  Giulio Genovese,et al.  Schizophrenia risk from complex variation of complement component 4 , 2016, Nature.

[24]  J. Smoller,et al.  A genome-wide association study of kynurenic acid in cerebrospinal fluid: implications for psychosis and cognitive impairment in bipolar disorder , 2015, Molecular Psychiatry.

[25]  N. Schork,et al.  Understanding and predicting suicidality using a combined genomic and clinical risk assessment approach , 2015, Molecular Psychiatry.

[26]  R. Lenroot,et al.  Elevated peripheral cytokines characterize a subgroup of people with schizophrenia displaying poor verbal fluency and reduced Broca's area volume , 2015, Molecular Psychiatry.

[27]  C. Svensson,et al.  Increased levels of IL-6 in the cerebrospinal fluid of patients with chronic schizophrenia--significance for activation of the kynurenine pathway. , 2015, Journal of psychiatry & neuroscience : JPN.

[28]  N. Schork,et al.  Discovery and validation of blood biomarkers for suicidality , 2013, Molecular Psychiatry.

[29]  Stephanie T. Lane,et al.  Clarifying the nature of startle habituation using latent curve modeling. , 2013, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[30]  B. Barres,et al.  The complement system: an unexpected role in synaptic pruning during development and disease. , 2012, Annual review of neuroscience.

[31]  J. Schröder,et al.  Activation of brain interleukin-1β in schizophrenia , 2009, Molecular Psychiatry.

[32]  John D. Lambris,et al.  The Classical Complement Cascade Mediates CNS Synapse Elimination , 2007, Cell.

[33]  L. Fañanás,et al.  Effect of interleukin‐1β gene functional polymorphism on dorsolateral prefrontal cortex activity in schizophrenic patients , 2007, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[34]  M. Geyer,et al.  Deficits in prepulse inhibition and habituation in never-medicated, first-episode schizophrenia , 2003, Biological Psychiatry.

[35]  H. Colten,et al.  Regulation of synthesis of complement protein C4 in human fibroblasts: cell- and gene-specific effects of cytokines and lipopolysaccharide. , 1994, Immunology.

[36]  Y. Niho,et al.  Effects of cell differentiation on the synthesis of the third and fourth component of complement (C3, C4) by the human monocytic cell line U937. , 1992, Immunology.

[37]  Christian Grillon,et al.  Gating and habituation of the startle reflex in schizophrenic patients. , 1992 .

[38]  S Cichon,et al.  A genome-wide association study of kynurenic acid in cerebrospinal fluid: implications for psychosis and cognitive impairment in bipolar disorder , 2013, Molecular Psychiatry.