PRMT6 methylation of RCC1 regulates mitosis, tumorigenicity, and radiation response of glioblastoma stem cells.

[1]  A. Mes-Masson,et al.  Ran GTPase: A Key Player in Tumor Progression and Metastasis , 2020, Frontiers in Cell and Developmental Biology.

[2]  G. Zachos,et al.  DNA damage response proteins regulating mitotic cell division: double agents preserving genome stability , 2020, The FEBS journal.

[3]  Chang-Young Jang,et al.  PRMT6-mediated H3R2me2a guides Aurora B to chromosome arms for proper chromosome segregation , 2020, Nature Communications.

[4]  Q. Guo,et al.  Small molecule modulators targeting protein kinase CK1 and CK2. , 2019, European journal of medicinal chemistry.

[5]  Jianqiang Bao,et al.  PRMT6 Promotes Lung Tumor Progression via the Alternate Activation of Tumor-Associated Macrophages , 2019, Molecular Cancer Research.

[6]  S. Richard,et al.  The regulation, functions and clinical relevance of arginine methylation , 2019, Nature Reviews Molecular Cell Biology.

[7]  Clare C. Davies,et al.  PRMTs and Arginine Methylation: Cancer's Best-Kept Secret? , 2019, Trends in molecular medicine.

[8]  J. Rich,et al.  Glioblastoma stem cells: lessons from the tumor hierarchy in a lethal cancer , 2019, Genes & development.

[9]  M. Ernst,et al.  Therapeutically exploiting STAT3 activity in cancer — using tissue repair as a road map , 2018, Nature Reviews Cancer.

[10]  Manu Sebastian,et al.  Mouse Models of Overexpression Reveal Distinct Oncogenic Roles for Different Type I Protein Arginine Methyltransferases. , 2018, Cancer research.

[11]  A. Villunger,et al.  Perturbing mitosis for anti‐cancer therapy: is cell death the only answer? , 2018, EMBO reports.

[12]  M. Wilkins,et al.  Characterization of Protein Methyltransferases Rkm1, Rkm4, Efm4, Efm7, Set5 and Hmt1 Reveals Extensive Post-Translational Modification. , 2018, Journal of molecular biology.

[13]  B. Strahl,et al.  The Arginine Methyltransferase PRMT6 Regulates DNA Methylation and Contributes to Global DNA Hypomethylation in Cancer. , 2017, Cell reports.

[14]  C. James,et al.  MST4 Phosphorylation of ATG4B Regulates Autophagic Activity, Tumorigenicity, and Radioresistance in Glioblastoma , 2017, Cancer cell.

[15]  A. Hjelmeland,et al.  Protein kinase CK2 is important for the function of glioblastoma brain tumor initiating cells , 2017, Journal of Neuro-Oncology.

[16]  S. Richard,et al.  Arginine Methylation: The Coming of Age. , 2017, Molecular cell.

[17]  C. Tsao,et al.  Emerging role of microRNA-21 in cancer (Review) , 2016 .

[18]  Lars J. Jensen,et al.  Proteome-wide analysis of arginine monomethylation reveals widespread occurrence in human cells , 2016, Science Signaling.

[19]  J. Ramalho-Carvalho,et al.  Histone methyltransferase PRMT6 plays an oncogenic role of in prostate cancer , 2016, Oncotarget.

[20]  Yu Pan,et al.  RCC1-dependent activation of Ran accelerates cell cycle and DNA repair, inhibiting DNA damage–induced cell senescence , 2016, Molecular biology of the cell.

[21]  Song Tan,et al.  Recognition of the nucleosome by chromatin factors and enzymes. , 2016, Current opinion in structural biology.

[22]  T. Hori,et al.  Chromatin binding of RCC1 during mitosis is important for its nuclear localization in interphase , 2016, Molecular biology of the cell.

[23]  T. Mak,et al.  Targeting Mitosis in Cancer: Emerging Strategies. , 2015, Molecular cell.

[24]  P. Raman,et al.  A LIN28B-RAN-AURKA Signaling Network Promotes Neuroblastoma Tumorigenesis. , 2015, Cancer cell.

[25]  J. Rich,et al.  Cancer stem cells in glioblastoma , 2015, Genes & development.

[26]  Tim J. Wigle,et al.  Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First PRMT6 Tool Compound. , 2015, ACS medicinal chemistry letters.

[27]  M. Dasso,et al.  RanBP1 governs spindle assembly by defining mitotic Ran-GTP production. , 2014, Developmental cell.

[28]  R. McLendon,et al.  EGFR phosphorylation of DCBLD2 recruits TRAF6 and stimulates AKT-promoted tumorigenesis. , 2014, The Journal of clinical investigation.

[29]  S. Cheshier,et al.  Casein Kinase 2α Regulates Glioblastoma Brain Tumor Initiating Cell Growth through the β-Catenin Pathway , 2014, Oncogene.

[30]  Wei Huang,et al.  CARM1 methylates chromatin remodeling factor BAF155 to enhance tumor progression and metastasis. , 2014, Cancer cell.

[31]  Se Hoon Kim,et al.  Mesenchymal differentiation mediated by NF-κB promotes radiation resistance in glioblastoma. , 2013, Cancer cell.

[32]  M. Wainberg,et al.  Automethylation of protein arginine methyltransferase 6 (PRMT6) regulates its stability and its anti-HIV-1 activity , 2013, Retrovirology.

[33]  Timothy L Bailey,et al.  Defining the RGG/RG motif. , 2013, Molecular cell.

[34]  P. Benos,et al.  Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3 , 2013, Proceedings of the National Academy of Sciences.

[35]  Fang Wang,et al.  An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells , 2013, Science.

[36]  P. Bastiaens,et al.  Cell cycle-dependent binding modes of the ran exchange factor RCC1 to chromatin. , 2013, Biophysical journal.

[37]  S. Stupp,et al.  Nanofiber-mediated inhibition of focal adhesion kinase sensitizes glioma stemlike cells to epidermal growth factor receptor inhibition. , 2013, Neuro-oncology.

[38]  M. Bedford,et al.  Protein arginine methyltransferases and cancer , 2012, Nature Reviews Cancer.

[39]  P. Tan,et al.  p53-Independent regulation of p21Waf1/Cip1 expression and senescence by PRMT6 , 2012, Nucleic acids research.

[40]  U. Bauer,et al.  The arginine methyltransferase PRMT6 regulates cell proliferation and senescence through transcriptional repression of tumor suppressor genes , 2012, Nucleic acids research.

[41]  Frédérick A. Mallette,et al.  Ablation of PRMT6 reveals a role as a negative transcriptional regulator of the p53 tumor suppressor , 2012, Nucleic acids research.

[42]  Lynda Chin,et al.  Emerging insights into the molecular and cellular basis of glioblastoma. , 2012, Genes & development.

[43]  A. Fojo,et al.  Inhibitors Targeting Mitosis: Tales of How Great Drugs against a Promising Target Were Brought Down by a Flawed Rationale , 2012, Clinical Cancer Research.

[44]  Penny A Jeggo,et al.  Understanding the limitations of radiation-induced cell cycle checkpoints , 2011, Critical reviews in biochemistry and molecular biology.

[45]  B. Ponder,et al.  Dysregulation of PRMT1 and PRMT6, Type I arginine methyltransferases, is involved in various types of human cancers , 2011, International journal of cancer.

[46]  Song Tan,et al.  Structure of RCC1 chromatin factor bound to the nucleosome core particle , 2010, Nature.

[47]  Song Tan,et al.  RCC1 uses a conformationally diverse loop region to interact with the nucleosome: a model for the RCC1-nucleosome complex. , 2010, Journal of molecular biology.

[48]  K. Aldape,et al.  EGF-induced ERK activation promotes CK2-mediated disassociation of alpha-Catenin from beta-Catenin and transactivation of beta-Catenin. , 2009, Molecular cell.

[49]  G. Smyth,et al.  ELDA: extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays. , 2009, Journal of immunological methods.

[50]  S. Clarke,et al.  Protein arginine methylation in mammals: who, what, and why. , 2009, Molecular cell.

[51]  J. L. Rosa,et al.  The RCC1 superfamily: from genes, to function, to disease. , 2008, Biochimica et biophysica acta.

[52]  P. Clarke,et al.  Spatial and temporal coordination of mitosis by Ran GTPase , 2008, Nature Reviews Molecular Cell Biology.

[53]  D. Altieri,et al.  Tumor cell dependence on Ran-GTP-directed mitosis. , 2008, Cancer research.

[54]  Y. Dou,et al.  PRMT6-mediated methylation of R2 in histone H3 antagonizes H3 K4 trimethylation. , 2007, Genes & development.

[55]  E. Guccione,et al.  Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive , 2007, Nature.

[56]  J. Shabanowitz,et al.  N-terminal α-methylation of RCC1 is necessary for stable chromatin association and normal mitosis , 2007, Nature Cell Biology.

[57]  J. Swedlow,et al.  Phosphorylation Regulates the Dynamic Interaction of RCC1 with Chromosomes during Mitosis , 2004, Current Biology.

[58]  Yixian Zheng,et al.  Phosphorylation of RCC1 in mitosis is essential for producing a high RanGTP concentration on chromosomes and for spindle assembly in mammalian cells. , 2004, Genes & development.

[59]  D. Wirtz,et al.  A mechanism of coupling RCC1 mobility to RanGTP production on the chromatin in vivo , 2003, The Journal of cell biology.

[60]  W. Moore,et al.  Targeting of RCC1 to Chromosomes Is Required for Proper Mitotic Spindle Assembly in Human Cells , 2002, Current Biology.

[61]  C. Allis,et al.  Chromatin docking and exchange activity enhancement of RCC1 by histones H2A and H2B. , 2001, Science.

[62]  A. Merlo,et al.  Frequent Co‐Alterations of TP53, p16/CDKN2A, p14ARF, PTEN Tumor Suppressor Genes in Human Glioma Cell Lines. , 1999, Brain pathology.

[63]  A Valencia,et al.  Model of the ran-RCC1 interaction using biochemical and docking experiments. , 1999, Journal of molecular biology.