Spectral morphological analysis of skin lesions with a polarization multispectral dermoscope.

Dermoscopy is the conventional technique used for the clinical inspection of human skin lesions. However, the identification of diagnostically relevant morphologies can become a complex task. We report on the development of a polarization multispectral dermoscope for the in vivo imaging of skin lesions. Linearly polarized illumination at three distinct spectral regions (470, 530 and 625 nm), is performed by high luminance LEDs. Processing of the acquired images, by means of spectral and polarization filtering, produces new contrast images, each one specific for melanin absorption, hemoglobin absorption, and single scattering. Analysis of such images could facilitate the identification of pathological morphologies.

[1]  R. Anderson,et al.  The optics of human skin. , 1981, The Journal of investigative dermatology.

[2]  Gianluca Petrillo,et al.  Vascular structures in skin tumors: a dermoscopy study. , 2004, Archives of dermatology.

[3]  Efthimios Kaxiras,et al.  Melanin absorption spectroscopy: new method for noninvasive skin investigation and melanoma detection. , 2008, Journal of biomedical optics.

[4]  J. Walsh,et al.  Comparative study of polarized light propagation in biologic tissues. , 2002, Journal of biomedical optics.

[5]  M. Leahy,et al.  Sub‐epidermal imaging using polarized light spectroscopy for assessment of skin microcirculation , 2007, Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging.

[6]  H Radousky,et al.  Deep subsurface imaging in tissues using spectral and polarization filtering. , 2000, Optics express.

[7]  Jessica C Ramella-Roman,et al.  Imaging skin pathology with polarized light. , 2002, Journal of biomedical optics.

[8]  S. Menzies,et al.  A sensitivity and specificity analysis of the surface microscopy features of invasive melanoma , 1996, Melanoma research.

[9]  G. Zonios,et al.  Skin melanin, hemoglobin, and light scattering properties can be quantitatively assessed in vivo using diffuse reflectance spectroscopy. , 2001, The Journal of investigative dermatology.

[10]  A. Marghoob,et al.  Differences in Dermoscopic Images from Nonpolarized Dermoscope and Polarized Dermoscope Influence the Diagnostic Accuracy and Confidence Level: A Pilot Study , 2008, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[11]  R. Webb,et al.  In vivo confocal scanning laser microscopy of human skin: melanin provides strong contrast. , 1995, The Journal of investigative dermatology.

[12]  W. Stolz,et al.  The ABCD rule of dermatoscopy. High prospective value in the diagnosis of doubtful melanocytic skin lesions. , 1994, Journal of the American Academy of Dermatology.

[13]  M. Oliviero,et al.  Automatic differentiation of melanoma from melanocytic nevi with multispectral digital dermoscopy: a feasibility study. , 2001, Journal of the American Academy of Dermatology.

[14]  Ralph Braun,et al.  The performance of SolarScan: an automated dermoscopy image analysis instrument for the diagnosis of primary melanoma. , 2005, Archives of dermatology.

[15]  Harold S Rabinovitz,et al.  Dermoscopy of pigmented skin lesions. , 2005, Journal of the American Academy of Dermatology.

[16]  E. Claridge,et al.  Spectrophotometric intracutaneous analysis: a new technique for imaging pigmented skin lesions , 2002, The British journal of dermatology.

[17]  K Wolff,et al.  In vivo epiluminescence microscopy of pigmented skin lesions. I. Pattern analysis of pigmented skin lesions. , 1987, Journal of the American Academy of Dermatology.

[18]  S. Jacques,et al.  Imaging superficial tissues with polarized light , 2000, Lasers in surgery and medicine.

[19]  Judith R. Mourant,et al.  Light scattering from cells: the contribution of the nucleus and the effects of proliferative status , 2000 .

[20]  A. Lallas,et al.  Dermoscopy in general dermatology. , 2013, Dermatologic clinics.

[21]  R. Anderson Polarized light examination and photography of the skin. , 1991, Archives of dermatology.

[22]  Anthony J. Durkin,et al.  Chromophore concentrations, absorption and scattering properties of human skin in-vivo. , 2009, Optics express.

[23]  G. Argenziano,et al.  Epiluminescence microscopy for the diagnosis of doubtful melanocytic skin lesions. Comparison of the ABCD rule of dermatoscopy and a new 7-point checklist based on pattern analysis. , 1998, Archives of dermatology.

[24]  Byungjo Jung,et al.  Multimodal facial color imaging modality for objective analysis of skin lesions. , 2008, Journal of Biomedical Optics.

[25]  J. C. van der Leun,et al.  FORWARD SCATTERING PROPERTIES OF HUMAN EPIDERMAL LAYERS , 1984, Photochemistry and photobiology.

[26]  George Papanicolaou,et al.  Optical polarization imaging in biological tissue , 2001, SPIE BiOS.