Impaired movement control in Alzheimer's disease

Movement accuracy in normal subjects depends on feedforward commands based on representation in memory of spatial and biomechanical features. Here we ask whether memory deficits in Alzheimer's disease (AD) interfere with movement planning and execution. Nine AD patients and nine age-matched controls moved a cursor to targets without seeing their limb. Starting and target positions were always visible on a screen, while, during movement, cursor position was either visible or blanked. Patients' paths showed discontinuous segments and prolonged movement time; movement inaccuracy, which increased without visual feedback, correlated significantly with scores of disease severity, working memory and attention.

[1]  M. Folstein,et al.  Clinical diagnosis of Alzheimer's disease , 1984, Neurology.

[2]  S. Ellias,et al.  Quantitative assessment of movement in Alzheimer's disease. , 1995, Journal of geriatric psychiatry and neurology.

[3]  Robert Sutton,et al.  Applications of Human Performance Models to System Design , 1989, Springer US.

[4]  L. Mansi,et al.  CORTICAL ABNORMALITIES IN ALZHEIMER'S DISEASE , 1984, Annals of neurology.

[5]  A. Schultz,et al.  Maintenance of balance, gait patterns, and obstacle clearance in Alzheimer's disease , 1995, Neurology.

[6]  G. Fullerton Psychology and physiology. , 1896 .

[7]  S. Folstein,et al.  "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. , 1975, Journal of psychiatric research.

[8]  J. Gordon,et al.  Learning a visuomotor transformation in a local area of work space produces directional biases in other areas. , 1995, Journal of neurophysiology.

[9]  E Capitani,et al.  Raven's coloured progressive matrices: normative values on 305 adult normal controls. , 1987, Functional neurology.

[10]  Robert Sessions Woodworth,et al.  THE ACCURACY OF VOLUNTARY MOVEMENT , 1899 .

[11]  R L Sainburg,et al.  Control of limb dynamics in normal subjects and patients without proprioception. , 1995, Journal of neurophysiology.

[12]  R. Wilson,et al.  Motor signs are infrequent in dementia of the Alzheimer type , 1984, Annals of neurology.

[13]  P. Goldman-Rakic,et al.  Functional magnetic resonance imaging of human prefrontal cortex activation during a spatial working memory task. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[14]  D. Buchner,et al.  Falls and fractures in patients with Alzheimer-type dementia. , 1987, JAMA.

[15]  John L Bradshaw,et al.  Response programming in dementia of the Alzheimer type: A kinematic analysis , 1997, Neuropsychologia.

[16]  Richard J. Jagacinski,et al.  Target Acquisition: Performance Measures, Process Models, and Design Implications , 1989 .