In vitro anticancer properties and biological evaluation of novel natural alkaloid jerantinine B.

[1]  T. Bradshaw,et al.  Novel antitumour indole alkaloid, Jerantinine A, evokes potent G2/M cell cycle arrest targeting microtubules , 2014, Investigational New Drugs.

[2]  Amandine Rovini,et al.  ROS-mediated EB1 phosphorylation through Akt/GSK3β pathway: implication in cancer cell response to microtubule-targeting agents , 2014, Oncotarget.

[3]  Davide Staedler,et al.  Total synthesis and biological evaluation of jerantinine E. , 2013, Angewandte Chemie.

[4]  N. Dhami Trends in Pharmacognosy: A modern science of natural medicines , 2013 .

[5]  T. Mak,et al.  Modulation of oxidative stress as an anticancer strategy , 2013, Nature Reviews Drug Discovery.

[6]  M. Diederich,et al.  Anticancer bioactivity of compounds from medicinal plants used in European medieval traditions. , 2013, Biochemical pharmacology.

[7]  S. Yip,et al.  Personalizing the treatment of pediatric medulloblastoma: Polo-like kinase 1 as a molecular target in high-risk children. , 2013, Cancer research.

[8]  A. Vollmar,et al.  Targeting apoptosis pathways by natural compounds in cancer: marine compounds as lead structures and chemical tools for cancer therapy. , 2013, Cancer letters.

[9]  I. Smal,et al.  End-binding proteins sensitize microtubules to the action of microtubule-targeting agents , 2013, Proceedings of the National Academy of Sciences.

[10]  Marta Cascante,et al.  Targeting cell cycle regulation in cancer therapy. , 2013, Pharmacology & therapeutics.

[11]  Hannah M Jones,et al.  Predicting pharmacokinetic profiles using in silico derived parameters. , 2013, Molecular pharmaceutics.

[12]  T. Kundu,et al.  Differential effects of garcinol and curcumin on histone and p53 modifications in tumour cells , 2013, BMC Cancer.

[13]  G. Barrera Oxidative Stress and Lipid Peroxidation Products in Cancer Progression and Therapy , 2012, ISRN oncology.

[14]  Shudong Wang,et al.  ZJU-6, a novel derivative of Erianin, shows potent anti-tubulin polymerisation and anti-angiogenic activities , 2012, Investigational New Drugs.

[15]  Antonello Caruso,et al.  Application of PBPK modeling to predict human intestinal metabolism of CYP3A substrates - an evaluation and case study using GastroPlus. , 2012, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[16]  J. Crison,et al.  The Use of Modeling Tools to Drive Efficient Oral Product Design , 2012, The AAPS Journal.

[17]  J. Parojčić,et al.  A case study on the in silico absorption simulations of levothyroxine sodium immediate‐release tablets , 2012, Biopharmaceutics & drug disposition.

[18]  S. Kuo,et al.  2-(3-Methoxyphenyl)-5-methyl-1,8-naphthyridin-4(1H)-one (HKL-1) induces G2/M arrest and mitotic catastrophe in human leukemia HL-60 cells. , 2012, Toxicology and applied pharmacology.

[19]  Jan Snoeys,et al.  From preclinical to human – prediction of oral absorption and drug–drug interaction potential using physiologically based pharmacokinetic (PBPK) modeling approach in an industrial setting: a workflow by using case example , 2012, Biopharmaceutics & drug disposition.

[20]  Xinyuan Zhang,et al.  The role of predictive biopharmaceutical modeling and simulation in drug development and regulatory evaluation. , 2011, International journal of pharmaceutics.

[21]  J. Jassem,et al.  Cellular Redox Pathways as a Therapeutic Target in the Treatment of Cancer , 2011, Drugs.

[22]  Richard A. Stanton,et al.  Drugs that target dynamic microtubules: A new molecular perspective , 2011, Medicinal research reviews.

[23]  Y. Degenhardt,et al.  Targeting Polo-like Kinase in Cancer Therapy , 2010, Clinical Cancer Research.

[24]  H. Koeffler,et al.  A novel treatment strategy targeting polo-like kinase 1 in hematological malignancies , 2009, Leukemia.

[25]  K. Komiyama,et al.  Jerantinines A-G, cytotoxic Aspidosperma alkaloids from Tabernaemontana corymbosa. , 2008, Journal of natural products.

[26]  Neil Parrott,et al.  Applications of physiologically based absorption models in drug discovery and development. , 2008, Molecular pharmaceutics.

[27]  Tycho Heimbach,et al.  Prodrugs: design and clinical applications , 2008, Nature Reviews Drug Discovery.

[28]  L. A. Fenu,et al.  Prediction of Human Pharmacokinetics Using Physiologically Based Modeling: A Retrospective Analysis of 26 Clinically Tested Drugs , 2007, Drug Metabolism and Disposition.

[29]  D. Rudolph,et al.  712 POSTER In vivo efficacy of BI 2536, a potent and selective inhibitor of the mitotic kinase Plk1, in human hematopoietic cancers , 2007 .

[30]  A. Ullrich,et al.  Targeting polo-like kinase 1 for cancer therapy , 2006, Nature Reviews Cancer.

[31]  Anupama Munshi,et al.  Clonogenic cell survival assay. , 2005, Methods in molecular medicine.

[32]  W. Plunkett,et al.  Transcription inhibition by flavopiridol: mechanism of chronic lymphocytic leukemia cell death. , 2005, Blood.

[33]  Thierry Lavé,et al.  Application of full physiological models for pharmaceutical drug candidate selection and extrapolation of pharmacokinetics to man. , 2005, Basic & clinical pharmacology & toxicology.

[34]  M. Hämäläinen,et al.  Predicting the intestinal absorption potential of hits and leads. , 2004, Drug discovery today. Technologies.

[35]  M. Jordan,et al.  Microtubules as a target for anticancer drugs , 2004, Nature Reviews Cancer.

[36]  Xiaoqi Liu,et al.  Polo-like kinase (Plk)1 depletion induces apoptosis in cancer cells , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[37]  W. Kamps,et al.  Vincristine induced apoptosis in acute lymphoblastic leukaemia cells: a mitochondrial controlled pathway regulated by reactive oxygen species? , 2002, International journal of oncology.

[38]  S. Kaufmann,et al.  G1 and G2 cell-cycle arrest following microtubule depolymerization in human breast cancer cells , 2002 .

[39]  J. Phillipson,et al.  Phytochemistry and medicinal plants. , 2001, Phytochemistry.

[40]  F. Levi-Schaffer,et al.  Role of reactive oxygen species (ROS) in apoptosis induction , 2000, Apoptosis.

[41]  M. Hengartner The biochemistry of apoptosis , 2000, Nature.

[42]  Alan G. Porter,et al.  Caspase-3 Is Required for DNA Fragmentation and Morphological Changes Associated with Apoptosis* , 1998, The Journal of Biological Chemistry.

[43]  M. Andreeff,et al.  Accumulation of cyclin B1, activation of cyclin B1‐dependent kinase and induction of programmed cell death in human epidermoid carcinoma KB cells treated with taxol , 1998, International journal of cancer.

[44]  I Nicoletti,et al.  A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. , 1991, Journal of immunological methods.

[45]  L. Hartwell,et al.  Checkpoints: controls that ensure the order of cell cycle events. , 1989, Science.

[46]  T. Mosmann Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. , 1983, Journal of immunological methods.

[47]  J. Riordan,et al.  Cell surface P-glycoprotein associated with multidrug resistance in mammalian cell lines. , 1983, Science.

[48]  J. Lee,et al.  In vitro reconstitution of calf brain microtubules: effects of solution variables. , 1977, Biochemistry.

[49]  M. M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. , 1976, Analytical biochemistry.

[50]  C. Cantor,et al.  Microtubule assembly in the absence of added nucleotides. , 1973, Proceedings of the National Academy of Sciences of the United States of America.

[51]  Sai Zhang,et al.  Vincristine induces cell cycle arrest and apoptosis in SH-SY5Y human neuroblastoma cells. , 2013, International journal of molecular medicine.

[52]  Paraskevi Giannakakou,et al.  Targeting microtubules for cancer chemotherapy. , 2005, Current medicinal chemistry. Anti-cancer agents.

[53]  J. Plumb Cell sensitivity assays: clonogenic assay. , 2004, Methods in molecular medicine.

[54]  S. Kaufmann,et al.  G(1) and G(2) cell-cycle arrest following microtubule depolymerization in human breast cancer cells. , 2002, The Journal of clinical investigation.

[55]  M. González-Cid,et al.  Comparison of the aneugenic effect of vinorelbine and vincristine in cultured human lymphocytes. , 1999, Mutagenesis.

[56]  D. M. Morgan,et al.  Tetrazolium (MTT) assay for cellular viability and activity. , 1998, Methods in molecular biology.