Motion Processing Deficits in Migraine

This study was designed to determine whether cortical motion processing abnormalities are present in individuals with migraine. Performance was measured using a visual motion coherence task (motion coherence perimetry, MCP) thought to depend on the operation of cortical area V5. Motion coherence thresholds were measured using stimuli composed of moving dots at 17 locations in the central ± 20° of visual field. Pre-cortical visual function was also measured using frequency doubling perimetry (FDP) at the same 17 locations. Several migraine subjects demonstrated significant pre-cortical visual functional abnormalities, however, most subjects had normal visual fields measured with FDP. Abnormal MCP performance was measured in 15 of 19 migraine-with-aura subjects, and 11 of 17 migraine-without-aura subjects. A decreased ability to detect coherent motion may possibly be explained by an increase in baseline neuronal noise, such as would be consistent with the concept of cortical hyperexcitability in migraine.

[1]  Chris A. Johnson,et al.  Frequency-doubling technology perimetry. , 2003, Ophthalmology clinics of North America.

[2]  J. Schoenen,et al.  Evoked potentials and transcranial magnetic stimulation in migraine: published data and viewpoint on their pathophysiologic significance , 2003, Clinical Neurophysiology.

[3]  J. Schoenen,et al.  Electrophysiological Studies in Migraine: A Comprehensive Review of Their Interest and Limitations , 2003, Cephalalgia : an international journal of headache.

[4]  D. Badcock,et al.  Contrast-processing dysfunction in both magnocellular and parvocellular pathways in migraineurs with or without aura. , 2003, Investigative ophthalmology & visual science.

[5]  K. Welch,et al.  Contrasts in cortical magnesium, phospholipid and energy metabolism between migraine syndromes , 2002, Neurology.

[6]  L. Battelli,et al.  Transcranial magnetic stimulation of visual area V5 in migraine , 2002, Neurology.

[7]  Michael Wall,et al.  Sensitivity and specificity of frequency doubling perimetry in neuro-ophthalmic disorders: a comparison with conventional automated perimetry. , 2002, Investigative ophthalmology & visual science.

[8]  G. Benedek,et al.  Spatial Contrast Sensitivity of Migraine Patients Without Aura , 2002, Cephalalgia : an international journal of headache.

[9]  Chris A. Johnson,et al.  Performance of efficient test procedures for frequency-doubling technology perimetry in normal and glaucomatous eyes. , 2002, Investigative ophthalmology & visual science.

[10]  Chris A. Johnson,et al.  Short-wavelength sensitivity deficits in patients with migraine. , 2002, Archives of ophthalmology.

[11]  Christopher C. Pack,et al.  Dynamic properties of neurons in cortical area MT in alert and anaesthetized macaque monkeys , 2001, Nature.

[12]  A J Shepherd,et al.  Increased visual after-effects following pattern adaptation in migraine: a lack of intracortical excitation? , 2001, Brain : a journal of neurology.

[13]  S. Drance,et al.  Risk factors for progression of visual field abnormalities in normal-tension glaucoma. , 2001, American journal of ophthalmology.

[14]  E. Chronicle,et al.  Visual Cortex Excitability in Migraine With and Without Aura , 2001, Headache.

[15]  T. Resink,et al.  Vasospasm, its Role in the Pathogenesis of Diseases with Particular Reference to the Eye , 2001, Progress in Retinal and Eye Research.

[16]  D. Badcock,et al.  Visual dysfunction between migraine events. , 2001, Investigative ophthalmology & visual science.

[17]  A. T. Smith,et al.  Spatiotemporal Frequency and Direction Sensitivities of Human Visual Areas Measured Using fMRI , 2000, NeuroImage.

[18]  A Berthoz,et al.  Visual perception of motion and 3-D structure from motion: an fMRI study. , 2000, Cerebral cortex.

[19]  D. Badcock,et al.  Visual field losses in subjects with migraine headaches. , 2000, Investigative ophthalmology & visual science.

[20]  F. Wilkinson,et al.  Visual Contrast Gain Control in Migraine: Measures of Visual Cortical Excitability and Inhibition , 2000, Cephalalgia : an international journal of headache.

[21]  C. Johnson,et al.  Frequency doubling technology perimetry for detection of glaucomatous visual field loss. , 2000, American journal of ophthalmology.

[22]  F. Wilkinson,et al.  Orientation Discrimination Thresholds in Migraine: A Measure of Visual Cortical Inhibition , 2000, Cephalalgia.

[23]  M W Greenlee,et al.  Human cortical areas underlying the perception of optic flow: brain imaging studies. , 2000, International review of neurobiology.

[24]  P. Martus,et al.  Migraine and tension headache in high-pressure and normal-pressure glaucoma. , 2000, American journal of ophthalmology.

[25]  B C Chauhan,et al.  Test-retest variability of frequency-doubling perimetry and conventional perimetry in glaucoma patients and normal subjects. , 1999, Investigative ophthalmology & visual science.

[26]  D. Broadway,et al.  Glaucoma and vasospasm , 1998, The British journal of ophthalmology.

[27]  E. Chronicle,et al.  Cognitive Processing in Migraine: A Failure To Find Facilitation in Patients with Aura , 1998, Cephalalgia : an international journal of headache.

[28]  S. Orgül,et al.  Optic nerve blood-flow abnormalities in glaucoma , 1998, Progress in Retinal and Eye Research.

[29]  L. Malis.  Spinal arteriovenous malformations: a personal review , 1998, Journal of Clinical Neuroscience.

[30]  J. Schoenen.  Cortical electrophysiology in migraine and possible pathogenetic implications. , 1998, Clinical neuroscience.

[31]  J. J. Wang,et al.  Is there an association between migraine headache and open-angle glaucoma? Findings from the Blue Mountains Eye Study. , 1997, Ophthalmology.

[32]  O. Meienberg,et al.  Cold-Induced Acral Vasospasm in Migraine as Assessed by Nailfold Video-Microscopy: Prevalence and Response to Migraine Prophylaxis , 1997, Angiology.

[33]  J. B. Levitt,et al.  Functional properties of neurons in macaque area V3. , 1997, Journal of neurophysiology.

[34]  C. Johnson,et al.  Screening for glaucomatous visual field loss with frequency-doubling perimetry. , 1997, Investigative ophthalmology & visual science.

[35]  M. Nicolela,et al.  Various glaucomatous optic nerve appearances: clinical correlations. , 1996, Ophthalmology.

[36]  A. Wilkins,et al.  Thresholds for Detection of a Target Against a Background Grating Suggest Visual Dysfunction in Migraine With Aura But Not Migraine Without Aura , 1995, Cephalalgia : an international journal of headache.

[37]  S. Kosslyn,et al.  Visual processing in migraineurs. , 1995, Brain : a journal of neurology.

[38]  E. Chronicle,et al.  Might Migraine Damage The Brain? , 1994, Cephalalgia : an international journal of headache.

[39]  David R. Badcock,et al.  Global motion perception: Interaction of the ON and OFF pathways , 1994, Vision Research.

[40]  K. Ruddock,et al.  Precortical dysfunction of spatial and temporal visual processing in migraine. , 1994, Journal of neurology, neurosurgery, and psychiatry.

[41]  R. Klein,et al.  Migraine headache and its association with open-angle glaucoma: the Beaver Dam Eye Study. , 1993, Investigative ophthalmology & visual science.

[42]  P. H. Schiller,et al.  The effects of V4 and middle temporal (MT) area lesions on visual performance in the rhesus monkey , 1993, Visual Neuroscience.

[43]  Scott N. J. Watamaniuk,et al.  Dependence of speed and direction perception on cinematogram dot density , 1993, Vision Research.

[44]  Ted Maddess,et al.  Performance of nonlinear visual units in ocular hypertension and glaucoma , 1992 .

[45]  J. Flammer.  Psychophysical mechanisms and treatment of vasospastic disorders in normal-tension glaucoma. , 1992, Bulletin de la Societe belge d'ophtalmologie.

[46]  JH Maunsell,et al.  Does primate motion perception depend on the magnocellular pathway? , 1991, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[47]  A. Wilkins,et al.  Colour and visual discomfort in migraineurs , 1991, The Lancet.

[48]  M. Shirakashi,et al.  Prevalence of migraine in low-tension glaucoma and primary open-angle glaucoma in Japanese. , 1991, The British journal of ophthalmology.

[49]  C. Baker,et al.  Residual motion perception in a "motion-blind" patient, assessed with limited-lifetime random dot stimuli , 1991, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[50]  O. Meienberg,et al.  Finger Microcirculation in Classical Migraine , 1991 .

[51]  N. Ramadan,et al.  The concept of migraine as a state of central neuronal hyperexcitability. , 1990, Neurologic clinics.

[52]  M. Soso,et al.  Migraine and stripe-induced visual discomfort. , 1989, Archives of neurology.

[53]  K. H. Britten,et al.  Neuronal correlates of a perceptual decision , 1989, Nature.

[54]  W. Newsome,et al.  A selective impairment of motion perception following lesions of the middle temporal visual area (MT) , 1988, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[55]  E. Switkes,et al.  Functional anatomy of macaque striate cortex. III. Color , 1988, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[56]  E. Switkes,et al.  Functional anatomy of macaque striate cortex. IV. Contrast and magno- parvo streams , 1988, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[57]  Giuseppe Orefice,et al.  Flunarizine in Prophylaxis of Childhood Migraine: A Double-Blind, Placebo-Controlled, Crossover Study , 1988, Cephalalgia : an international journal of headache.

[58]  M Schulzer,et al.  Response of blood flow to warm and cold in normal and low-tension glaucoma patients. , 1988, American journal of ophthalmology.

[59]  Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain. Headache Classification Committee of the International Headache Society. , 1988, Cephalalgia : an international journal of headache.

[60]  F. Ederer.  Migraine and low-tension glaucoma. A case control study. , 1986, Investigative ophthalmology & visual science.

[61]  A. Wilkins,et al.  A neurological basis for visual discomfort. , 1984, Brain : a journal of neurology.

[62]  D H Kelly,et al.  Nonlinear visual responses to flickering sinusoidal gratings. , 1981, Journal of the Optical Society of America.

[63]  D. H. Kelly.  Frequency Doubling in Visual Responses , 1966 .