Application of Proteomics in Food Technology and Food Biotechnology: Process Development, Quality Control and Product Safety

Summary Human food is a very complex biological mixture and food processing and safety are very important and essential disciplines. Proteomics technology using different high-performance separation techniques such as two-dimensional gel electrophoresis, one-dimensional and multidimensional chromatography, combined with high-resolution mass spectrometry has the power to monitor the protein composition of foods and their changes during the production process. The use of proteomics in food technology is presented, especially for characterization and standardization of raw materials, process development, detection of batch-to-batch variations and quality control of the final product. Further attention is paid to the aspects of food safety, especially regarding biological and microbial safety and the use of genetically modified foods.

[1]  A. R. Brandão,et al.  Image analysis of two-dimensional gel electrophoresis for comparative proteomics of transgenic and non-transgenic soybean seeds. , 2010, Journal of proteomics.

[2]  A. D’Alessandro,et al.  The egg white and yolk interactomes as gleaned from extensive proteomic data. , 2010, Journal of proteomics.

[3]  P. Kaur,et al.  Proteome Analysis of a Food Borne Pathogen Enteroaggregative Escherichia coli under Acid Stress , 2010 .

[4]  M. Affolter,et al.  OMICS-rooted studies of milk proteins, oligosaccharides and lipids. , 2009, Journal of proteomics.

[5]  R. Levin The Use of Molecular Methods for Detecting and Discriminating Salmonella Associated with Foods — A Review , 2009 .

[6]  P. Ferranti,et al.  Analysis of food proteins and peptides by mass spectrometry-based techniques. , 2009, Journal of chromatography. A.

[7]  J. M. Gallardo,et al.  Mass spectrometry characterization of species-specific peptides from arginine kinase for the identification of commercially relevant shrimp species. , 2009, Journal of proteome research.

[8]  J. Clifton,et al.  Proteomic characterization of plasma‐derived clotting factor VIII–von Willebrand factor concentrates , 2009, Electrophoresis.

[9]  K. Doh-ura,et al.  Autoantibody to glial fibrillary acidic protein in the sera of cattle with bovine spongiform encephalopathy , 2009, Proteomics.

[10]  J. Rappsilber,et al.  Proteomic profiling of PrP27‐30‐enriched preparations extracted from the brain of hamsters with experimental scrapie , 2009, Proteomics.

[11]  M. Affolter,et al.  Label-free quantitative proteomics of two Bifidobacterium longum strains. , 2009, Journal of proteomics.

[12]  M. Leippe,et al.  2‐D DIGE analysis of the proteome of extracts from peanut variants reveals striking differences in major allergen contents , 2009, Proteomics.

[13]  H. Zerby,et al.  Functional proteomic analysis predicts beef tenderness and the tenderness differential. , 2009, Journal of agricultural and food chemistry.

[14]  A. Nasi,et al.  Proteomic approaches to study structure, functions and toxicity of legume seeds lectins. Perspectives for the assessment of food quality and safety. , 2009, Journal of proteomics.

[15]  S. Maleki,et al.  Resolution and identification of major peanut allergens using a combination of fluorescence two-dimensional differential gel electrophoresis, Western blotting and Q-TOF mass spectrometry. , 2009, Journal of proteomics.

[16]  Jay J Thelen,et al.  Validation of gel-free, label-free quantitative proteomics approaches: applications for seed allergen profiling. , 2009, Journal of proteomics.

[17]  G. Aldini,et al.  Searching for allergens in maize kernels via proteomic tools. , 2009, Journal of proteomics.

[18]  J. Clifton,et al.  Proteomic analysis for process development and control of therapeutic protein separation from human plasma , 2009, Electrophoresis.

[19]  P. Ximénez-Embún,et al.  Proteomic analysis by two-dimensional differential gel electrophoresis (2D DIGE) of a high-pressure effect in Bacillus cereus. , 2009, Journal of agricultural and food chemistry.

[20]  J. Jardin,et al.  Comparison of electrospray and matrix-assisted laser desorption ionization on the same hybrid quadrupole time-of-flight tandem mass spectrometer: application to bidimensional liquid chromatography of proteins from bovine milk fraction. , 2009, Journal of chromatography. A.

[21]  M. Desvaux,et al.  Comparative subproteome analyses of planktonic and sessile Staphylococcus xylosus C2a: new insight in cell physiology of a coagulase-negative Staphylococcus in biofilm. , 2009, Journal of proteome research.

[22]  W. Weckwerth,et al.  Evidence for novel tomato seed allergens: IgE-reactive legumin and vicilin proteins identified by multidimensional protein fractionation-mass spectrometry and in silico epitope modeling. , 2009, Journal of proteome research.

[23]  C. D. Page,et al.  Prion disease diagnosis by proteomic profiling. , 2009, Journal of proteome research.

[24]  Qibin Zhang,et al.  A perspective on the Maillard reaction and the analysis of protein glycation by mass spectrometry: probing the pathogenesis of chronic disease. , 2009, Journal of proteome research.

[25]  Nichollas E. Scott,et al.  Campylobacter proteomics: guidelines, challenges and future perspectives , 2009, Expert review of proteomics.

[26]  R. Chen,et al.  Amyloid-degrading ability of nattokinase from Bacillus subtilis natto. , 2009, Journal of agricultural and food chemistry.

[27]  D. Bannerman,et al.  Proteomic analysis of differentially expressed proteins in bovine milk during experimentally induced Escherichia coli mastitis. , 2008, Journal of dairy science.

[28]  Jérôme Garin,et al.  Protein Standard Absolute Quantification (PSAQ) for improved investigation of staphylococcal food poisoning outbreaks , 2008, Proteomics.

[29]  F. Jessen,et al.  Effects of tetracycline administration on the proteomic profile of pig muscle samples (L. dorsi). , 2008, Journal of agricultural and food chemistry.

[30]  B. Carratù,et al.  Determination of alpha-amylase inhibitor activity of phaseolamin from kidney bean (Phaseolus vulgaris) in dietary supplements by HPAEC-PAD. , 2008, Analytica chimica acta.

[31]  W. Schulz-Schaeffer,et al.  Physiological role of the cellular prion protein (PrPc): protein profiling study in two cell culture systems. , 2008, Journal of proteome research.

[32]  L. Ruiz,et al.  Proteomics of stress response in Bifidobacterium. , 2008, Frontiers in bioscience : a journal and virtual library.

[33]  D. Josić,et al.  Application of proteomics in biotechnology – Microbial proteomics , 2008, Biotechnology journal.

[34]  K. Shimakura,et al.  Sarcoplasmic Calcium-Binding Protein: Identification as a New Allergen of the Black Tiger Shrimp Penaeus monodon , 2008, International Archives of Allergy and Immunology.

[35]  A. Cifuentes,et al.  CE‐MS of zein proteins from conventional and transgenic maize , 2007, Electrophoresis.

[36]  Mark R Marten,et al.  Proteomics of filamentous fungi. , 2007, Trends in biotechnology.

[37]  K. Hollung,et al.  Application of proteomics to understand the molecular mechanisms behind meat quality. , 2007, Meat science.

[38]  K. Glenn Nutritional and safety assessments of foods and feeds nutritionally improved through biotechnology: lysine maize as a case study. , 2007, Journal of AOAC International.

[39]  F. Jessen,et al.  Protein and lipid oxidation during frozen storage of rainbow trout (Oncorhynchus mykiss). , 2007, Journal of agricultural and food chemistry.

[40]  A. Maldonado,et al.  Plant proteome analysis: A 2006 update , 2007, Proteomics.

[41]  T. Ishii,et al.  Proteomic analysis of wheat flour allergens. , 2007, Journal of agricultural and food chemistry.

[42]  Prateek Gupta,et al.  Genomics and proteomics in process development: opportunities and challenges. , 2007, Trends in biotechnology.

[43]  G. Pessi,et al.  Global transcriptome analysis of the heat shock response of Bifidobacterium longum. , 2007, FEMS microbiology letters.

[44]  Rita Batista,et al.  A Proteomic Study to Identify Soya Allergens – The Human Response to Transgenic versus Non-Transgenic Soya Samples , 2007, International Archives of Allergy and Immunology.

[45]  Hongwei Xie,et al.  Identification of carbonylated proteins from enriched rat skeletal muscle mitochondria using affinity chromatography‐stable isotope labeling and tandem mass spectrometry , 2007, Proteomics.

[46]  Y. Nagashima,et al.  Molecular cloning of tropomyosins identified as allergens in six species of crustaceans. , 2007, Journal of agricultural and food chemistry.

[47]  T. Sklaviadis,et al.  Identification of proteins with high affinity for refolded and native PrPC , 2006, Proteomics.

[48]  J. Callahan,et al.  Confirmation of peanut protein using peptide markers in dark chocolate using liquid chromatography-tandem mass spectrometry (LC-MS/MS). , 2006, Journal of agricultural and food chemistry.

[49]  Dilip Chokshi Toxicity Studies of Blockal, a Dietary Supplement Containing Phase 2 Starch Neutralizer (Phase 2), a Standardized Extract of the Common White Kidney Bean (Phaseolus vulgaris) , 2006, International journal of toxicology.

[50]  M. Dacasto,et al.  Illegal Drug Treatments and Drug Metabolism: Biomarkers or Not? , 2006, Veterinary Research Communications.

[51]  A. Urbani,et al.  The Proteomic Approach as a Tool to Detect the Illegal Treatment of Cattle with Performance Enhancing Agents , 2006, Veterinary Research Communications.

[52]  C. Gillen,et al.  Molecular characterization of the sarcoplasmic calcium-binding protein (SCP) from crayfish Procambarus clarkii. , 2006, Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology.

[53]  S. Vilain,et al.  Multivariate approach to comparing whole-cell proteomes of Bacillus cereus indicates a biofilm-specific proteome. , 2006, Journal of proteome research.

[54]  Liuyu Huang,et al.  A Proteome Reference Map and Proteomic Analysis of Bifidobacterium longum NCC2705*S , 2006, Molecular & Cellular Proteomics.

[55]  N. Birmingham,et al.  Allergic and Anaphylactic Response to Sesame Seeds in Mice: Identification of Ses i 3 and Basic Subunit of 11s Globulins as Allergens , 2006, International Archives of Allergy and Immunology.

[56]  S. Salminen,et al.  Human Studies on Probiotics: What Is Scientifically Proven , 2006 .

[57]  J. Clifton,et al.  Proteomic characterization of inter‐alpha inhibitor proteins from human plasma , 2006, Proteomics.

[58]  A. Urbani,et al.  Proteomic investigation in the detection of the illicit treatment of calves with growth‐promoting agents , 2006, Proteomics.

[59]  S. Natarajan,et al.  Characterization of storage proteins in wild (Glycine soja) and cultivated (Glycine max) soybean seeds using proteomic analysis. , 2006, Journal of agricultural and food chemistry.

[60]  J. Callahan,et al.  Detection, confirmation, and quantification of staphylococcal enterotoxin B in food matrixes using liquid chromatography--mass spectrometry. , 2006, Analytical chemistry.

[61]  M. Morzel,et al.  Proteome analysis of the sarcoplasmic fraction of pig semimembranosus muscle: implications on meat color development. , 2006, Journal of agricultural and food chemistry.

[62]  Mahalingam Ramkumar,et al.  Effects of subminimum inhibitory concentrations of antibiotics on the Pasteurella multocida proteome. , 2006, Journal of proteome research.

[63]  F. Jessen,et al.  Changes in cod muscle proteins during frozen storage revealed by proteome analysis and multivariate data analysis , 2006, Proteomics.

[64]  K. Engel,et al.  Application of two-dimensional gel electrophoresis to interrogate alterations in the proteome of genetically modified crops. 1. Assessing analytical validation. , 2006, Journal of agricultural and food chemistry.

[65]  Markus Lipp,et al.  Application of two-dimensional gel electrophoresis to interrogate alterations in the proteome of gentically modified crops. 3. Assessing unintended effects. , 2006, Journal of agricultural and food chemistry.

[66]  W. Ens,et al.  Determination and characterization of site-specific N-glycosylation using MALDI-Qq-TOF tandem mass spectrometry: case study with a plant protease. , 2006, Analytical chemistry.

[67]  K. Isono,et al.  Genome sequencing and analysis of Aspergillus oryzae , 2005, Nature.

[68]  E. Quemeneur,et al.  Industrial process proteomics: alfalfa protein patterns during wet fractionation processing. , 2005, Biotechnology and bioengineering.

[69]  Laurent Debrauwer,et al.  Selection of biomarkers by a multivariate statistical processing of composite metabonomic data sets using multiple factor analysis. , 2005, Journal of proteome research.

[70]  Cécile Canlet,et al.  Homeostatic signature of anabolic steroids in cattle using 1H-13C HMBC NMR metabonomics. , 2005, Journal of proteome research.

[71]  R. Asero Plant Food Allergies: A Suggested Approach to Allergen-Resolved Diagnosis in the Clinical Practice by Identifying Easily Available Sensitization Markers , 2005, International Archives of Allergy and Immunology.

[72]  J. Tabet,et al.  Carbonylation of milk powder proteins as a consequence of processing conditions , 2005, Proteomics.

[73]  Peter B Harrington,et al.  Immunomagnetic isolation of enterohemorrhagic Escherichia coli O157:H7 from ground beef and identification by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and database searches. , 2005, Analytical chemistry.

[74]  J. Banfield,et al.  Community Proteomics of a Natural Microbial Biofilm , 2005, Science.

[75]  Richard E. Goodman,et al.  Assessing Genetically Modified Crops to Minimize the Risk of Increased Food Allergy: A Review , 2005, International Archives of Allergy and Immunology.

[76]  P. Brigidi,et al.  A proteomic view of Bifidobacterium infantis generated by multi‐dimensional chromatography coupled with tandem mass spectrometry , 2005, Proteomics.

[77]  B. Chromy,et al.  Host–pathogen interactions: a proteomic view , 2005, Expert review of proteomics.

[78]  Gennaro Marino,et al.  Monitoring food quality by microfluidic electrophoresis, gas chromatography, and mass spectrometry techniques: effects of aquaculture on the sea bass (Dicentrarchus labrax). , 2005, Analytical chemistry.

[79]  H. Deeth,et al.  Analysis of O‐glycosylation site occupancy in bovine κ‐casein glycoforms separated by two‐dimensional gel electrophoresis , 2005, Proteomics.

[80]  Eugen Damoc,et al.  Immunoaffinity reactors for prion protein qualitative analysis , 2005, Proteomics.

[81]  G. Junter,et al.  Immobilized viable microbial cells: from the process to the proteome ... or the cart before the horse , 2004 .

[82]  J. Grosclaude,et al.  Hydrolysis of the amyloid prion protein and nonpathogenic meat and bone meal by anaerobic thermophilic prokaryotes and streptomyces subspecies. , 2004, Journal of agricultural and food chemistry.

[83]  J. Jenkins,et al.  Structural, Biological, and Evolutionary Relationships of Plant Food Allergens Sensitizing via the Gastrointestinal Tract , 2004, Critical reviews in food science and nutrition.

[84]  J. Jahier,et al.  Proteomic analysis of aneuploid lines in the homeologous group 1 of the hexaploid wheat cultivar Courtot , 2004, Proteomics.

[85]  Yuji Haishima,et al.  Proteomic Analysis of Putative Latex Allergens , 2004, International Archives of Allergy and Immunology.

[86]  T. Adachi,et al.  Expression and epitope analysis of the major allergenic protein Fag e 1 from buckwheat. , 2004, Journal of plant physiology.

[87]  Marina Carbonaro,et al.  Proteomics: present and future in food quality evaluation , 2004 .

[88]  F. Cánovas,et al.  Plant proteome analysis , 2004, Proteomics.

[89]  Esther J Kok,et al.  Comparative safety assessment for biotech crops. , 2003, Trends in biotechnology.

[90]  A. Zeng,et al.  Combined use of proteomic analysis and enzyme activity assays for metabolic pathway analysis of glycerol fermentation by Klebsiella pneumoniae , 2003, Biotechnology and bioengineering.

[91]  G. Reese,et al.  Seafood Allergy and Allergens: A Review , 2003, Marine Biotechnology.

[92]  Karin Sauer,et al.  The genomics and proteomics of biofilm formation , 2003, Genome Biology.

[93]  J. M. Gallardo,et al.  Proteomics as a tool for the investigation of seafood and other marine products. , 2003, Journal of proteome research.

[94]  B. Chiang,et al.  Proteomics and Immunological Analysis of a Novel Shrimp Allergen, Pen m 21 , 2003, The Journal of Immunology.

[95]  W. R. Peterson,et al.  Characterization of the soluble allergenic proteins of cashew nut (Anacardium occidentale L.). , 2002, Journal of agricultural and food chemistry.

[96]  B. Wedzicha,et al.  Food chemistry: Acrylamide is formed in the Maillard reaction , 2002, Nature.

[97]  Andrew Cockburn,et al.  Assuring the safety of genetically modified (GM) foods: the importance of an holistic, integrative approach. , 2002, Journal of biotechnology.

[98]  A. Namane,et al.  A proteomic study of Escherichia coli O157:H7 NCTC 12900 cultivated in biofilm or in planktonic growth mode. , 2002, FEMS microbiology letters.

[99]  P. Roepstorff,et al.  Identification of protein degradation during post-mortem storage of pig meat. , 2002, Journal of agricultural and food chemistry.

[100]  G. Junter,et al.  Immobilized-cell physiology: current data and the potentialities of proteomics , 2002 .

[101]  A. Scaloni,et al.  Characterization of heat-induced lactosylation products in caseins by immunoenzymatic and mass spectrometric methodologies. , 2002, Biochimica et biophysica acta.

[102]  J. Theron,et al.  Proteomic Analysis Reveals Differential Protein Expression by Bacillus cereus during Biofilm Formation , 2002, Applied and Environmental Microbiology.

[103]  A. Namane,et al.  Comparison of protein patterns of Listeria monocytogenes grown in biofilm or in planktonic mode by proteomic analysis. , 2002, FEMS microbiology letters.

[104]  L. Smeller Pressure-temperature phase diagrams of biomolecules. , 2002, Biochimica et biophysica acta.

[105]  D. Mollé,et al.  Heat-induced covalent complex between casein micelles and beta-lactoglobulin from goat's milk: identification of an involved disulfide bond. , 2002, Journal of agricultural and food chemistry.

[106]  D. Schmid,et al.  Broadband detection electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry to reveal enzymatically and chemically induced deamidation reactions within peptides. , 2001, Analytical chemistry.

[107]  M. Ishida,et al.  Identification of tropomyosin as a major allergen in the octopus Octopus vulgaris and elucidation of its IgE‐binding epitopes , 2001 .

[108]  R. Lametsch,et al.  Proteome analysis applied to meat science: characterizing postmortem changes in porcine muscle. , 2001, Journal of agricultural and food chemistry.

[109]  H. Gabius,et al.  Plant lectins: Occurrence, biochemistry, functions and applications , 2001, Glycoconjugate Journal.

[110]  K. Murayama,et al.  Rapid determination of parvalbumin amino acid sequence from Rana catesbeiana (pI 4.78) by combination of ESI mass spectrometry, protein sequencing, and amino acid analysis. , 2000, Journal of biochemistry.

[111]  S. G. Uzogara,et al.  The impact of genetic modification of human foods in the 21st century: a review. , 2000, Biotechnology advances.

[112]  G. Schmidt,et al.  Basic features of the stress response in three species of bifidobacteria: B. longum, B. adolescentis, and B. breve. , 2000, International journal of food microbiology.

[113]  K. Kailasapathy,et al.  Survival and therapeutic potential of probiotic organisms with reference to Lactobacillus acidophilus and Bifidobacterium spp. , 2000, Immunology and cell biology.

[114]  M. Friedman,et al.  Chemistry, biochemistry, nutrition, and microbiology of lysinoalanine, lanthionine, and histidinoalanine in food and other proteins. , 1999, Journal of agricultural and food chemistry.

[115]  R. Wolfe,et al.  Testosterone injection stimulates net protein synthesis but not tissue amino acid transport. , 1998, The American journal of physiology.

[116]  E. Damme,et al.  Prevalence, biological activity and genetic manipulation of lectins in foods , 1996 .

[117]  W. Jaffé,et al.  Heat-labile growth-inhibiting factors in beans (Phaseolus vulgaris). , 1968, The Journal of nutrition.

[118]  J. Wiltfang,et al.  Ubiquitin as potential cerebrospinal fluid marker of Creutzfeldt–Jakob disease , 2010, Proteomics.

[119]  A. D’Alessandro,et al.  The red blood cell proteome and interactome: an update. , 2010, Journal of proteome research.

[120]  W. Hancock,et al.  Mass spectrometric determination of disulfide linkages in recombinant therapeutic proteins using online LC-MS with electron-transfer dissociation. , 2009, Analytical chemistry.

[121]  Yufei Wang,et al.  Analysis of host-inducing proteome changes in bifidobacterium longum NCC2705 grown in Vivo. , 2008, Journal of proteome research.

[122]  Jianzhong Han,et al.  Proteomics: present and future in food science and technology , 2008 .

[123]  A. Strom,et al.  Identification of prion protein binding proteins by combined use of far‐Western immunoblotting, two dimensional gel electrophoresis and mass spectrometry , 2006, Proteomics.

[124]  K. Engel,et al.  Application of two-dimensional gel electrophoresis to interrogate alterations in the proteome of genetically modified crops. 2. Assessing natural variability. , 2006, Journal of agricultural and food chemistry.

[125]  A. Schmidt,et al.  A novel strategy for quantitative proteomics using isotope‐coded protein labels , 2005, Proteomics.

[126]  V. Brözel,et al.  Novel method for the proteomic investigation of a dairy-associated Bacillus cereus biofilm. , 2001, FEMS microbiology letters.