Associations of serum EBV DNA and gammopathy with post‐transplant lymphoproliferative disease

Abstract:  Background:  Post‐transplant lymphoproliferative disease (PTLD) is a life‐threatening complication of immunosuppression following transplantation. Epstein–Barr virus (EBV) and gammopathy in serum are associated with PTLD, but these two parameters have not been evaluated in parallel for their association with PTLD.

[1]  G. Pruneri,et al.  Comparative genome‐wide profiling of post‐transplant lymphoproliferative disorders and diffuse large B‐cell lymphomas , 2006, British journal of haematology.

[2]  D. Porter,et al.  Serum protein electrophoresis abnormalities in adult solid organ transplant patients with post‐transplant lymphoproliferative disorder * , 2005, Clinical transplantation.

[3]  G. Pantaleo,et al.  Functional Heterogeneity of Memory CD4 T Cell Responses in Different Conditions of Antigen Exposure and Persistence1 , 2005, The Journal of Immunology.

[4]  V. Kindler,et al.  Human tonsil implants xenotransplanted in SCID mice display broad lymphocytic diversity and cellular activation profile similar to those in the original lymphoid organ , 2005, Xenotransplantation.

[5]  B. Dastugue,et al.  Identification of biologic markers of the premature rupture of fetal membranes: Proteomic approach , 2003, Proteomics.

[6]  L. Applegate,et al.  Plasticity of protein expression during culture of fetal skin cells , 2003, Electrophoresis.

[7]  D. Porter,et al.  Post-transplant lymphoproliferative disorder: a review , 2003, Bone Marrow Transplantation.

[8]  H. Wada,et al.  Significance of serial real‐time PCR monitoring of EBV genome load in living donor liver transplantation , 2002, Clinical transplantation.

[9]  P. Bucsky,et al.  PATIENTS AT RISK FOR DEVELOPMENT OF POSTTRANSPLANT LYMPHOPROLIFERATIVE DISORDER: PLASMA VERSUS PERIPHERAL BLOOD MONONUCLEAR CELLS AS MATERIAL FOR QUANTIFICATION OF EPSTEIN-BARR VIRAL LOAD BY USING REAL-TIME QUANTITATIVE POLYMERASE CHAIN REACTION1,2 , 2001, Transplantation.

[10]  D. Samuel,et al.  Detection of gammopathy by serum protein electrophoresis for predicting and managing therapy of lymphoproliferative disorder in 911 recipients of liver transplants. , 2001, Blood.

[11]  D. Nadal,et al.  Dynamics of Epstein‐Barr virus DNA levels in serum during EBV‐associated disease , 2001, Journal of medical virology.

[12]  D. Hébert,et al.  Utility of semiquantitative polymerase chain reaction for Epstein-Barr virus to measure virus load in pediatric organ transplant recipients with and without posttransplant lymphoproliferative disease. , 2001, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[13]  S. Cockfield.  Identifying the patient at risk for post‐transplant lymphoproliferative disorder , 2001, Transplant infectious disease : an official journal of the Transplantation Society.

[14]  J. Reyes,et al.  Epstein–Barr virus load monitoring: its role in the prevention and management of post‐transplant lymphoproliferative disease , 2001, Transplant infectious disease : an official journal of the Transplantation Society.

[15]  Jaap M Middeldorp,et al.  Toward Standardization of Epstein-Barr Virus DNA Load Monitoring: Unfractionated Whole Blood as Preferred Clinical Specimen , 2001, Journal of Clinical Microbiology.

[16]  D. Ellis,et al.  Pediatric Solid-Organ Transplant Recipients Carry Chronic Loads of Epstein-Barr Virus Exclusively in the Immunoglobulin D-Negative B-Cell Compartment , 2001, Journal of Clinical Microbiology.

[17]  Y. Lo,et al.  Quantitative analysis of circulating cell‐free Epstein–Barr virus (EBV) DNA levels in patients with EBV‐associated lymphoid malignancies , 2000, British journal of haematology.

[18]  P. Francioli,et al.  Preemptive treatment approach to cytomegalovirus (CMV) infection in solid organ transplant patients: relationship between compliance with the guidelines and prevention of CMV morbidity , 2000, Transplant infectious disease : an official journal of the Transplantation Society.

[19]  N. Ohkohchi,et al.  Usefulness of quantitative real‐time polymerase chain reaction in following up patients with Epstein–Barr virus infection after liver transplantation , 2000, Clinical transplantation.

[20]  F. Baldanti,et al.  High Levels of Epstein-Barr Virus DNA in Blood of Solid-Organ Transplant Recipients and Their Value in Predicting Posttransplant Lymphoproliferative Disorders , 2000, Journal of Clinical Microbiology.

[21]  A. Osterhaus,et al.  Development of a Real-Time Quantitative Assay for Detection of Epstein-Barr Virus , 2000, Journal of Clinical Microbiology.

[22]  A. Niveleau,et al.  Oligo‐monoclonal immunoglobulins frequently develop during concurrent cytomegalovirus (CMV) and Epstein–Barr virus (EBV) infections in patients after renal transplantation , 1999, Clinical and experimental immunology.

[23]  Jaap M Middeldorp,et al.  Monitoring of Epstein-Barr Virus DNA Load in Peripheral Blood by Quantitative Competitive PCR , 1999, Journal of Clinical Microbiology.

[24]  T. Jaskowski,et al.  Comparison of capillary zone and immunosubtraction with agarose gel and immunofixation electrophoresis for detecting and identifying monoclonal gammopathies. , 1999, American journal of clinical pathology.

[25]  A. Limaye,et al.  Detection of Epstein-Barr Virus DNA in Sera from Transplant Recipients with Lymphoproliferative Disorders , 1999, Journal of Clinical Microbiology.

[26]  T. Morishima,et al.  Quantitative Analysis of Epstein-Barr Virus Load by Using a Real-Time PCR Assay , 1999, Journal of Clinical Microbiology.

[27]  A. Secchi,et al.  Mono-oligoclonal immunoglobulin abnormalities in diabetic patients after kidney transplantation: influence of simultaneous pancreas graft , 1998, Diabetologia.

[28]  E. Cesarman,et al.  The morphologic and molecular genetic categories of posttransplantation lymphoproliferative disorders are clinically relevant , 1998, Cancer.

[29]  P. Chatellard,et al.  Single tube competitive PCR for quantitation of CMV DNA in the blood of HIV+ and solid organ transplant patients. , 1998, Journal of virological methods.

[30]  D. Samuel,et al.  Occurrence of gammopathies and lymphoproliferative disorders in liver transplant recipients randomized to tacrolimus (FK506)- or cyclosporine-based immunosuppression. , 1998, Liver Transplantation and Surgery.

[31]  M. Picot,et al.  Prevalence of monoclonal immunoglobulins after liver transplantation: relationship with posttransplant lymphoproliferative disorders. , 1998, Transplantation.

[32]  T. Hauet,et al.  High prevalence and usual persistence of serum monoclonal immunoglobulins evidenced by sensitive methods in renal transplant recipients. , 1997, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[33]  N. Harris,et al.  Posttransplant lymphoproliferative disorders: summary of Society for Hematopathology Workshop. , 1997, Seminars in diagnostic pathology.

[34]  T. Habermann,et al.  Development of monoclonal gammopathy precedes the development of Epstein-Barr virus-induced posttransplant lymphoproliferative disorder. , 1996, Liver transplantation and surgery : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[35]  D. Samuel,et al.  Monoclonal and oligoclonal gammopathies in liver transplant recipients. , 1994, Transplantation.

[36]  A. Fischer,et al.  PROSPECTIVE STUDY OF THE OCCURRENCE OF MONOCLONAL GAMMAPATHIES FOLLOWING BONE MARROW TRANSPLANTATION IN YOUNG CHILDREN , 1990, Transplantation.

[37]  R. Buckley,et al.  Development of multiple monoclonal serum immunoglobulins (multiclonal gammopathy) following both HLA-identical unfractionated and T cell-depleted haploidentical bone marrow transplantation in severe combined immunodeficiency , 1990, Journal of Clinical Immunology.

[38]  A. Haverich,et al.  High incidence of monoclonal immunoglobulins in patients after liver or heart transplantation. , 1988, Transplantation.

[39]  L. Hutt-Fletcher,et al.  B cell activation by cytomegalovirus , 1983, The Journal of experimental medicine.

[40]  M. Hirsch,et al.  Functional properties of T lymphocytes and their subsets in cytomegalovirus mononucleosis. , 1983, Journal of immunology.

[41]  A. Solomon,et al.  Transient monoclonal gammopathy associated with cytomegalovirus infection. , 1974, Blood.

[42]  Theodore A. Mork,et al.  Young Children , 1949, Nature.

[43]  F. Baldanti,et al.  Post-transplant lymphoproliferative disorders: improved outcome after clinico-pathologically tailored treatment. , 2002, Haematologica.

[44]  V. Romagosa,et al.  Post-transplant lymphomas: a 20-year epidemiologic, clinical and pathologic study in a single center. , 2001, Haematologica.

[45]  J. Tissot,et al.  ELECTROPHORESIS | Two-Dimensional Polyacrylamide Gel Electrophoresis , 2000 .

[46]  M. Picot,et al.  PREVALENCE OF MONOCLONAL IMMUNOGLOBULINS AFTER LIVER TRANSPLANTATION , 1998 .

[47]  D. Hochstrasser,et al.  Two‐dimensional electrophoresis as an aid in the analysis of the clonality of immunoglobulins , 1993, Electrophoresis.

[48]  B. Fenton.  Two-dimensional polyacrylamide gel electrophoresis. , 1993, Methods in molecular biology.

[49]  P. Lang,et al.  Monoclonal immunoglobulins in patients with renal transplants: characterization, evolution and risk factors. , 1992, Transplant international : official journal of the European Society for Organ Transplantation.

[50]  J. Preiksaitis,et al.  Cyclosporine-associated lymphoproliferation, despite controlled cyclosporine blood concentrations, in a renal allograft recipient. , 1985, Proceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress.