Density of Upper Respiratory Colonization With Streptococcus pneumoniae and Its Role in the Diagnosis of Pneumococcal Pneumonia Among Children Aged <5 Years in the PERCH Study

Upper airway pneumococcal colonization density among children hospitalized with World Health Organization–defined pneumonia was associated with microbiologically confirmed pneumococcal pneumonia (MCPP). The optimal colonization density threshold for discriminating MCPP from non-MCPP was ≥7 log10 copies/mL (sensitivity, 64.3%, specificity, 92.2%).

S. Madhi | K. O'Brien | S. Zeger | R. Karron | D. Murdoch | W. B. | L. Hammitt | H. Endtz | S. Maloney | J. Scott | D. Thea | T. Anderson | Y. Jahan | W. A. Brooks | D. Feikin | Zhenke Wu | J. Mwansa | M. Antonio | E. Machuka | O. Levine | A. Kamau | H. Baggett | S. Howie | S. Kazungu | Christine Prosperi | J. Rhodes | L. Mwananyanda | P. Seidenberg | J. Chipeta | G. Mackenzie | M. Tapia | S. Sow | U. Onwuchekwa | M. T. | E. Wangeci Kagucia | D. Moore | K. Kotloff | K. Zaman | W. Paveenkittiporn | C. Bunthi | K. Z | L. Hossain | P. Akarasewi | Boubou Tamboura | A. Touré | M. Sylla | W. Fu | G. Kwenda | Melissa M Higdon | Maria Deloria Knoll | P. Adrian | Juliet O. Awori | V. Baillie | Jane Crawley | A. DeLuca | A. Driscoll | B. Ebruke | N. Fancourt | D. Goswami | M. Groome | N. Kourouma | L. Kuwanda | Mengying Li | N. Mahomed | J. McLellan | Joanne L. Mitchell | S. Morpeth | Azwifarwi Mudau | Daniel E Park | Pongpun Sawatwong | A. Shamsul | Somwe wa Somwe | S. Thamthitiwat | Nora L. Watson | S. Zaman | L. H. | H. Ashraf | Barameht Piralam | R. K. | D. G. | M. K | O. L. | Justin M. Mulindwa | D. M. | D. M. | J. Duncan | M. Deloria Knoll | M. Higdon | M. Ominde | K. K. | M. H | S. M. | S. M. | S. Z | M. K. | K L O S M D D R A N A J Nicholas Wei L L M M E R A M O L K F D D Fancourt Fu H H Wangeci Kagucia K L | K. O | D. F | A. D | A. D | D. P | C. P. | N. W | D. M. | S. C H | B. E | M. A. | J. G S | J. A. | S. M | S. S. | V. B | H. B | D. T | S. Z. | B. Tamboura | J. Mulindwa | R. K | V. B. | K. Z. | Locadiah Kuwanda | J. Scott | D. M | D. F. | S. M | M. T. | S. S | D. T. | Somwe Wa Somwe | D. G. | O. L. | A. d | A. J. D | M. H. | D. R. M | D. G. | S. M | D. M. | Syed M. A. Zaman | A. D. | A. D. | C. P. | D. R. M | S C M | S A M

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