Abnormally increased vocal responses to pitch feedback perturbations in patients with cerebellar degeneration.

Cerebellar degeneration (CD) has deleterious effects on speech motor behavior. Recently, a dissociation between feedback and feedforward control of speaking was observed in CD: Whereas CD patients exhibited reduced adaptation across trials to consistent formant feedback alterations, they showed enhanced within-trial compensation for unpredictable formant feedback perturbations. In this study, it was found that CD patients exhibit abnormally increased within-trial vocal compensation responses to unpredictable pitch feedback perturbations. Taken together with recent findings, the results indicate that CD is associated with a general hypersensitivity to auditory feedback during speaking.

[1]  Coarticulation • Suprasegmentals,et al.  Acoustic Phonetics , 2019, The SAGE Encyclopedia of Human Communication Sciences and Disorders.

[2]  Mitsuo Kawato,et al.  Internal models for motor control and trajectory planning , 1999, Current Opinion in Neurobiology.

[3]  B. Day,et al.  Influence of vision on upper limb reaching movements in patients with cerebellar ataxia. , 1998, Brain : a journal of neurology.

[4]  Keith Johnson,et al.  Partial Compensation for Altered Auditory Feedback: A Tradeoff with Somatosensory Feedback? , 2012, Language and speech.

[5]  Satrajit S. Ghosh,et al.  A neuroimaging study of premotor lateralization and cerebellar involvement in the production of phonemes and syllables. , 2008, Journal of speech, language, and hearing research : JSLHR.

[6]  D. Wolpert,et al.  Internal models in the cerebellum , 1998, Trends in Cognitive Sciences.

[7]  Satrajit S. Ghosh,et al.  fMRI investigation of unexpected somatosensory feedback perturbation during speech , 2011, NeuroImage.

[8]  R. Cowie,et al.  Postlingually Acquired Deafness: Speech Deterioration and the Wider Consequences , 1992 .

[9]  Benjamin Parrell,et al.  Impaired Feedforward Control and Enhanced Feedback Control of Speech in Patients with Cerebellar Degeneration , 2017, The Journal of Neuroscience.

[10]  S. M. Morton,et al.  Cerebellar Contributions to Locomotor Adaptations during Splitbelt Treadmill Walking , 2006, The Journal of Neuroscience.

[11]  S. Nagarajan,et al.  Vocal motor control and central auditory impairments in unilateral vocal fold paralysis , 2018, The Laryngoscope.

[12]  D. Nowak,et al.  Preserved and impaired aspects of predictive grip force control in cerebellar patients , 2005, Clinical Neurophysiology.

[13]  Richard B. Ivry,et al.  Consensus Paper: Roles of the Cerebellum in Motor Control—The Diversity of Ideas on Cerebellar Involvement in Movement , 2011, The Cerebellum.

[14]  Frank H Guenther,et al.  The DIVA model: A neural theory of speech acquisition and production , 2011, Language and cognitive processes.

[15]  S. Nagarajan,et al.  Abnormal Speech Motor Control in Individuals with 16p11.2 Deletions , 2017, Scientific Reports.

[16]  Raymond D. Kent,et al.  A speaking task analysis of the dysarthria in cerebellar disease. , 1997, Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics.

[17]  Michael I. Jordan,et al.  Sensorimotor adaptation in speech production. , 1998, Science.

[18]  Frank H. Guenther,et al.  An fMRI investigation of syllable sequence production , 2006, NeuroImage.

[19]  Bernard S. Lee.  Some Effects of Side‐Tone Delay , 1950 .

[20]  J. Krakauer,et al.  A computational neuroanatomy for motor control , 2008, Experimental Brain Research.

[21]  C. Larson,et al.  Voice F0 responses to manipulations in pitch feedback. , 1998, The Journal of the Acoustical Society of America.

[22]  Jason A. Tourville,et al.  Neural mechanisms underlying auditory feedback control of speech , 2008, NeuroImage.

[23]  Hermann Ackermann,et al.  Cerebellar contributions to speech production and speech perception: psycholinguistic and neurobiological perspectives , 2008, Trends in Neurosciences.

[24]  K. Munhall,et al.  Compensation following real-time manipulation of formants in isolated vowels. , 2006, The Journal of the Acoustical Society of America.

[25]  S. Gilman,et al.  Speech disorders in cerebellar disease , 1978, Annals of neurology.

[26]  K. Spencer,et al.  The neural basis of ataxic dysarthria , 2008, The Cerebellum.

[27]  Charles R. Larson,et al.  Interactions between auditory and somatosensory feedback for voice F0 control , 2008, Experimental Brain Research.

[28]  Srikantan S. Nagarajan,et al.  Speech Production as State Feedback Control , 2011, Front. Hum. Neurosci..

[29]  G. Hickok.  Computational neuroanatomy of speech production , 2012, Nature Reviews Neuroscience.

[30]  K. Vossel,et al.  Abnormal vocal behavior predicts executive and memory deficits in Alzheimer's disease , 2017, Neurobiology of Aging.

[31]  Oleg Korzyukov,et al.  Functional role of delta and theta band oscillations for auditory feedback processing during vocal pitch motor control , 2015, Front. Neurosci..

[32]  Jeffery A. Jones,et al.  Control of vocalization at utterance onset and mid-utterance: Different mechanisms for different goals , 2009, Brain Research.

[33]  Srikantan S. Nagarajan,et al.  Reality Monitoring and Feedback Control of Speech Production Are Related Through Self-Agency , 2018, Front. Hum. Neurosci..