Quantitative Absorption and Scattering Spectra in Thick Tissues Using Broadband Diffuse Optical Spectroscopy

Near-infraredspectroscopyisawell-establishedtechniquethathasbeenappliedtoavarietyofmedicaldiagnosticproblems.Recentexamplesincludedetectingperipheralvasculardis-ease,compartmentsyndrome,andvariousformsofcancer(Fantinietal.,1998;Zonios et al.,1999; Benaron et al., 2000; Giannotti et al., 2000; Tromberg et al., 2000; Wariar et al.,2000; Cerussi 2001). Because near-infrared light penetrates bone, near-infrared spec-troscopy is also widely used for noninvasive brain imaging to monitor cortical activation,neonatal cerebral oxygenation, and hematomas (Adcock et al., 1999; Fantini et al., 1999;Benaron et al.,2000;Springettetal.,2000).Theuseofmodel-based

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