An Oscillation-Based Technique for Degradation Monitoring of Sensing and Actuation Electrodes Within Microfluidic Systems

There is significant interest in the use of electrodes for sensing or actuation in bio-fluidic microsystems. Within these systems high levels of reliability are crucial and complimented by requirements for extremely low probabilities of false positive and false negatives. This paper extends previous work on impedance and oscillation based condition monitoring of electrode arrays by investigating the application of oscillation built-in self-test to a microfluidic based electrodes for conductance measurements and a system level implementation for monitoring multiple electrodes on-line.

[1]  B. Wheeler,et al.  Chronic electrical stimulation of cultured hippocampal networks increases spontaneous spike rates , 2009, Journal of Neuroscience Methods.

[2]  Pascal Nouet,et al.  Evaluation of the oscillation-based test methodology for micro-electro-mechanical systems , 2002, Proceedings 20th IEEE VLSI Test Symposium (VTS 2002).

[3]  A. Agogino,et al.  A resonant accelerometer with two-stage microleverage mechanisms fabricated by SOI-MEMS technology , 2005, IEEE Sensors Journal.

[4]  Andrew Richardson,et al.  Built-in Test Solutions for the Electrode Structures in Bio-Fluidic Microsystems , 2009, 2009 14th IEEE European Test Symposium.

[5]  H.G. Kerkhoff,et al.  VHDL-AMS fault simulation for testing DNA bio-sensing arrays , 2005, IEEE Sensors, 2005..

[6]  Krishnendu Chakrabarty Design Automation and Test Solutions for Digital Microfluidic Biochips , 2010, IEEE Transactions on Circuits and Systems I: Regular Papers.

[7]  Krishnendu Chakrabarty,et al.  On-Line Testing of Lab-on-Chip Using Reconfigurable Digital-Microfluidic Compactors , 2009, International Journal of Parallel Programming.

[8]  Arun Ravindran,et al.  Efficient parallel testing and diagnosis of digital microfluidic biochips , 2009, JETC.

[9]  A. Richardson,et al.  Embedded test & health monitoring strategies for bio-fluidic microystems , 2008, 2008 2nd Electronics System-Integration Technology Conference.

[10]  Martin Z. Bazant,et al.  Induced-charge electrokinetic phenomena , 2003 .

[11]  B. Kaminska,et al.  Oscillation-test strategy for analog and mixed-signal integrated circuits , 1996, Proceedings of 14th VLSI Test Symposium.

[12]  RavindranArun,et al.  Efficient parallel testing and diagnosis of digital microfluidic biochips , 2009 .

[13]  Fei Su,et al.  Testing of droplet-based microelectrofluidic systems , 2003, International Test Conference, 2003. Proceedings. ITC 2003..

[14]  Leif Nyholm,et al.  Electrochemical techniques for lab-on-a-chip applications. , 2005, The Analyst.

[15]  B. Wheeler,et al.  Chronic network stimulation enhances evoked action potentials , 2010, Journal of neural engineering.

[16]  Ulrich Egert,et al.  Biological application of microelectrode arrays in drug discovery and basic research , 2003, Analytical and bioanalytical chemistry.

[17]  K. Chakrabarty,et al.  Ensuring the operational health of droplet-based microelectrofluidic biosensor systems , 2005, IEEE Sensors Journal.

[18]  R. Maboudian,et al.  Corrosion mechanism and surface passivation strategies of polycrystalline silicon electrodes , 2011 .

[19]  Hans G. Kerkhoff Testing Microelectronic Biofluidic Systems , 2007, IEEE Design & Test of Computers.

[20]  S. Martinoia,et al.  Extracellular recordings from locally dense microelectrode arrays coupled to dissociated cortical cultures , 2009, Journal of Neuroscience Methods.

[21]  M. Ramasubramanian,et al.  An integrated fiberoptic–microfluidic device for agglutination detection and blood typing , 2009, Biomedical microdevices.

[22]  Hans G. Kerkhoff,et al.  Design and Test of an Oscillation-based System Architecture for DNA Sensor Arrays , 2005 .

[23]  Krishnendu Chakrabarty,et al.  Fault Diagnosis in Lab-on-Chip Using Digital Microfluidic Logic Gates , 2008, 2008 IEEE 14th International Mixed-Signals, Sensors, and Systems Test Workshop.

[24]  M. Sawan,et al.  Bacteria growth monitoring through an on-chip capacitive sensor , 2008, 2008 IEEE 14th International Mixed-Signals, Sensors, and Systems Test Workshop.

[25]  Fei Su,et al.  Defect-oriented testing and diagnosis of digital microfluidics-based biochips , 2005, IEEE International Conference on Test, 2005..

[26]  Andrew Richardson,et al.  An on-line monitoring technique for electrode degradation in bio-fluidic microsystems , 2010, 2010 IEEE International Test Conference.

[27]  Ingo Bojak,et al.  Classification of cortical microcircuits based on micro-electrode-array data from slices of rat barrel cortex , 2009, Neural Networks.

[28]  Fei Su,et al.  Microfluidics-Based Biochips: Technology Issues, Implementation Platforms, and Design-Automation Challenges , 2006, IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems.