Cognitive impairment in major depression.

In the past decade, a growing bulk of evidence has accumulated to suggest that patients suffering from major depression (MD) present some cognitive disturbances, such as impairment in attention, working memory, and executive function, including cognitive inhibition, problem- and task-planning. If the results of short-term memory assessment in depressed patients are equivocal, a general consensus exists that memory problems are secondary to attentional dysfunctions, and reflect the inability to concentrate. Moreover, both unipolar and bipolar patients show evidence of impaired verbal learning that has been commonly interpreted as reflecting an inability to transfer information from short-term to long-term storage. According to some authors, there would be a gender-related as well age-related specificity of some disturbances. Depressed patients also show impairments of executive functions and their recent exploration through brain imaging techniques has recently permitted to formulate some general hypotheses on the possible involvement of different brain areas in MD.

[1]  C. Mormont.  The influence of age and depression on intellectual and memory performances. , 1984, Acta psychiatrica Belgica.

[2]  D. Kupfer,et al.  Psychomotor activity in mania. , 1974, Archives of general psychiatry.

[3]  K. Oedegaard,et al.  Impairment across executive functions in recurrent major depression , 2004, Nordic journal of psychiatry.

[4]  M. Taylor,et al.  Importance of schizophrenic symptoms in the diagnosis of mania. , 1981, The American journal of psychiatry.

[5]  M. Shapiro,et al.  An investigation of the nature of cognitive impairment in co-operative psychiatric patients. , 1955, The British journal of medical psychology.

[6]  D. Rubinow,et al.  Cortisol hypersecretion and cognitive impairment in depression. , 1984, Archives of general psychiatry.

[7]  D. Rapaport,et al.  Diagnostic psychological testing: The theory, statistical evaluation, and diagnostic application of a battery of tests: Volume II. , 1946 .

[8]  L. S. Strömgren.  The influence of depression on memory , 1977, Acta psychiatrica Scandinavica.

[9]  R. Senf,et al.  Psychopathology of schizophrenia and depression. I. Effect of amytal and amphetamine sulfate on level and maintenance of attention. , 1952, The American journal of psychiatry.

[10]  Klaus P. Ebmeier,et al.  The cognitive neuropsychology of depression in the elderly , 2007, Psychological Medicine.

[11]  W Hulstijn,et al.  Retardation in depression: assessment by means of simple motor tasks. , 1999, Journal of affective disorders.

[12]  F. Goodwin,et al.  Depression during mania: clinical observations and theoretical implications. , 1972, The American journal of psychiatry.

[13]  E. Granholm,et al.  Verbal memory deficits associated with major affective disorders: a comparison of unipolar and bipolar patients. , 1987, Journal of affective disorders.

[14]  K. Hugdahl,et al.  Attention profile in schizophrenia compared with depression: differential effects of processing speed, selective attention and vigilance , 2003, Acta psychiatrica Scandinavica.

[15]  N. Raoux,et al.  Executive functioning and verbal memory in young patients with unipolar depression and schizophrenia , 1999, Psychiatry Research.

[16]  Depressive deficits in memory: Processing initiative and resource allocation. , 1990 .

[17]  H. Mayberg.  Modulating dysfunctional limbic-cortical circuits in depression: towards development of brain-based algorithms for diagnosis and optimised treatment. , 2003, British medical bulletin.

[18]  M. Caligiuri,et al.  Motor and cognitive aspects of motor retardation in depression. , 2000, Journal of affective disorders.

[19]  B. Carroll,et al.  Speech pause time: a marker of psychomotor retardation among endogenous depressives. , 1981, Biological psychiatry.

[20]  Til Wykes,et al.  Effects of depressed mood on objective and subjective measures of attention. , 2003, The Journal of neuropsychiatry and clinical neurosciences.

[21]  M. Jarvik,et al.  Memory Functions in Depression: Improvement With Antidepressant Medication , 1976 .

[22]  C Stough,et al.  Evidence of an early information processing speed deficit in unipolar major depression , 2002, Psychological Medicine.

[23]  G. Repovš,et al.  Executive dysfunction in late-onset depression. , 2008, Psychiatria Danubina.

[24]  R. Bornstein,et al.  Relative memory deficits in recurrent versus first-episode major depression on a word-list learning task. , 1999, Neuropsychology.

[25]  A. W. Siegman,et al.  Anxiety and depression in speech. , 1970, Journal of consulting and clinical psychology.

[26]  J. Suvisaari,et al.  A review on cognitive impairments in depressive and anxiety disorders with a focus on young adults. , 2008, Journal of affective disorders.

[27]  Herbert Weingartner,et al.  Thinking Disorder in Depression: Logic and Strategy in an Abstract Reasoning Task , 1983 .

[28]  K. Hall,et al.  Some factors affecting reaction times to auditory stimuli in mental patients. , 1954, The Journal of mental science.

[29]  H. Sackeim,et al.  Effects of depression and ECT on anterograde memory , 1986, Biological Psychiatry.

[30]  P. Wittman.  The Babcock deterioration test in state hospital practice. , 1933 .

[31]  I. Blackburn.  Mental and Psychomotor Speed in Depression and Mania , 1975, British Journal of Psychiatry.

[32]  G. MacQueen,et al.  Recollection memory deficits in patients with major depressive disorder predicted by past depressions but not current mood state or treatment status , 2002, Psychological Medicine.

[33]  R. Post,et al.  Halstead-Reitan Category Test in Bipolar and Unipolar Affective Disorders: Relationship to Age and Phase of Illness , 1980, The Journal of nervous and mental disease.

[34]  Richard J. Porter,et al.  Neurocognitive impairment in drug-free patients with major depressive disorder , 2003, British Journal of Psychiatry.

[35]  R. Cancro,et al.  Depression and mania , 1988 .

[36]  M. Lader.  Anxiety and Depression , 1983 .

[37]  R. Fieve,et al.  Depressive symptoms in patients with unipolar and bipolar affective disorder. , 1976, Comprehensive psychiatry.

[38]  W. Miller.  Psychological deficit in depression. , 1975, Psychological bulletin.

[39]  J. Ottosson,et al.  Memory functions in endogenous depression before and after electroconvulsive therapy. , 1961, Archives of general psychiatry.

[40]  E. A. Berg,et al.  A simple objective technique for measuring flexibility in thinking. , 1948, The Journal of general psychology.

[41]  D. Murphy,et al.  Intellectual Function in Primary Affective Disorder , 1982, British Journal of Psychiatry.

[42]  M. Åsberg,et al.  Memory effects of clomipramine treatment: Relationship to CSF monoamine metabolites and drug concentrations in plasma , 1991, Biological Psychiatry.

[43]  D. Murphy,et al.  Influence of affective states and psychoactive drugs on verbal learning and memory. , 1973, The American journal of psychiatry.

[44]  J. Kocsis,et al.  Memory Deficits in Depression: Evidence Utilizing the Wechsler Memory Scale , 1980, Perceptual and motor skills.

[45]  D. Murphy,et al.  Idiosyncratic patterns of learning and word association during mania. , 1971, The American journal of psychiatry.

[46]  M. Thase,et al.  Prefrontal cortical dysfunction in depression determined by Wisconsin Card Sorting Test performance. , 1999, The American journal of psychiatry.

[47]  B. Carroll,et al.  Decrease in speech pause times with treatment of endogenous depression. , 1980, Biological psychiatry.

[48]  W. Morgan.  Selected physiological and psychomotor correlates of depression in psychiatric patients. , 1968, Research quarterly.

[49]  M. Harrow,et al.  PSYCHOMOTOR RETARDATION IN DEPRESSIVE SYNDROMES , 1967, The Journal of nervous and mental disease.

[50]  Richard J. McPartland,et al.  Psychomotor activity in affective states. , 1974 .

[51]  C. Bradshaw,et al.  Elongation of Pause-Time in Speech: A Simple, Objective Measure of Motor Retardation in Depression , 1976, British Journal of Psychiatry.