Autophagy: A protective mechanism in response to stress and inflammation.

Autophagy is one of the intracellular systems that is responsible for protein trafficking (degradation/recycling) in eukaryotic cells. This ubiquitous process contributes to cytosolic homeostasis, but its deregulation is often associated with various pathologies, including neurodegenerative diseases and cancer and pathologies with an altered inflammatory response. This review provides an overview of autophagy and discusses its regulation, function and future therapeutic possibilities, with a focus on the role of autophagy in inflammation.

[1]  S. Belouzard,et al.  Ubiquitylation of leptin receptor OB‐Ra regulates its clathrin‐mediated endocytosis , 2006, The EMBO journal.

[2]  Junying Yuan,et al.  Autophagy in cell death: an innocent convict? , 2005, The Journal of clinical investigation.

[3]  D. Green,et al.  Pharmacological manipulation of cell death: clinical applications in sight? , 2005, The Journal of clinical investigation.

[4]  Joo‐Hang Kim,et al.  Essential Roles of Atg5 and FADD in Autophagic Cell Death , 2005, Journal of Biological Chemistry.

[5]  S. Ostrand-Rosenberg,et al.  Presentation of Endogenously Synthesized MHC Class II-Restricted Epitopes by MHC Class II Cancer Vaccines Is Independent of Transporter Associated with Ag Processing and the Proteasome1 , 2005, The Journal of Immunology.

[6]  Hiroshi Sagara,et al.  Escape of Intracellular Shigella from Autophagy , 2005, Science.

[7]  F. Blanchard,et al.  Histone deacetylase inhibitors: new drugs for the treatment of inflammatory diseases? , 2005, Drug discovery today.

[8]  Philippe Dessen,et al.  Inhibition of Macroautophagy Triggers Apoptosis , 2005, Molecular and Cellular Biology.

[9]  Chi Li,et al.  Growth Factor Regulation of Autophagy and Cell Survival in the Absence of Apoptosis , 2005, Cell.

[10]  J. Neefjes,et al.  [The 2004 Nobel Prize in Chemistry for the discovery of ubiquitin-mediated protein degradation]. , 2004, Nederlands tijdschrift voor geneeskunde.

[11]  Takeshi Tokuhisa,et al.  The role of autophagy during the early neonatal starvation period , 2004, Nature.

[12]  V. Deretic,et al.  Autophagy Is a Defense Mechanism Inhibiting BCG and Mycobacterium tuberculosis Survival in Infected Macrophages , 2004, Cell.

[13]  N. Mizushima.  Methods for monitoring autophagy. , 2004, The international journal of biochemistry & cell biology.

[14]  P. Codogno,et al.  Regulation and role of autophagy in mammalian cells. , 2004, The international journal of biochemistry & cell biology.

[15]  J. Dice,et al.  Mechanisms of chaperone-mediated autophagy. , 2004, The international journal of biochemistry & cell biology.

[16]  J. Gee,et al.  Autophagy, proteasomes, lipofuscin, and oxidative stress in the aging brain. , 2004, The international journal of biochemistry & cell biology.

[17]  Yiping Gu,et al.  Effect of IGF‐1 on the balance between autophagy of dysfunctional mitochondria and apoptosis , 2004, FEBS letters.

[18]  A. Cuervo,et al.  Activation of chaperone-mediated autophagy during oxidative stress. , 2004, Molecular biology of the cell.

[19]  P. Saftig,et al.  Role for Rab7 in maturation of late autophagic vacuoles , 2004, Journal of Cell Science.

[20]  S. Subramani,et al.  Peroxisome turnover by micropexophagy: an autophagy-related process. , 2004, Trends in cell biology.

[21]  R. Stan,et al.  Fibroblast growth factor 2 endocytosis in endothelial cells proceed via syndecan-4-dependent activation of Rac1 and a Cdc42-dependent macropinocytic pathway , 2004, Journal of Cell Science.

[22]  E. Raymond,et al.  Safety and pharmacokinetics of escalated doses of weekly intravenous infusion of CCI-779, a novel mTOR inhibitor, in patients with cancer. , 2004, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[23]  E. White,et al.  Exploiting different ways to die. , 2004, Genes & development.

[24]  K. Kirkegaard,et al.  Cellular autophagy: surrender, avoidance and subversion by microorganisms , 2004, Nature Reviews Microbiology.

[25]  Jayanta Debnath,et al.  Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is required for induction of autophagy during lumen formation in vitro. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[26]  Y. Kondo,et al.  Inhibition of platelet-derived growth factor signalling induces autophagy in malignant glioma cells , 2004, British Journal of Cancer.

[27]  A. Cuervo.  Autophagy: in sickness and in health. , 2004, Trends in cell biology.

[28]  T. Yoshimori.  Autophagy: a regulated bulk degradation process inside cells. , 2004, Biochemical and biophysical research communications.

[29]  M. Matsui,et al.  In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. , 2003, Molecular biology of the cell.

[30]  V. Lelyveld,et al.  A Single Protease, Apg4B, Is Specific for the Autophagy-related Ubiquitin-like Proteins GATE-16, MAP1-LC3, GABARAP, and Apg8L* , 2003, Journal of Biological Chemistry.

[31]  R. Flavell,et al.  A Salmonella protein causes macrophage cell death by inducing autophagy , 2003, The Journal of cell biology.

[32]  L. Salgado,et al.  Growth factor deprivation induces an alternative non-apoptotic death mechanism that is inhibited by Bcl2 in cells derived from neural precursor cells. , 2003, Journal of hematotherapy & stem cell research.

[33]  B. Nichols.  Caveosomes and endocytosis of lipid rafts , 2003, Journal of Cell Science.

[34]  R. Kessin,et al.  Macroautophagy is dispensable for intracellular replication of Legionella pneumophila in Dictyostelium discoideum , 2003, Molecular microbiology.

[35]  Daniel J Klionsky,et al.  A unified nomenclature for yeast autophagy-related genes. , 2003, Developmental cell.

[36]  Ivan R. Nabi,et al.  Caveolae/raft-dependent endocytosis , 2003, The Journal of cell biology.

[37]  G. Juhász,et al.  The Drosophila homolog of Aut1 is essential for autophagy and development , 2003, FEBS letters.

[38]  S. Pattingre,et al.  Amino Acids Interfere with the ERK1/2-dependent Control of Macroautophagy by Controlling the Activation of Raf-1 in Human Colon Cancer HT-29 Cells* , 2003, The Journal of Biological Chemistry.

[39]  E. Jaffee,et al.  Major histocompatibility complex class II‐restricted presentation of a cytosolic antigen by autophagy , 2003, European journal of immunology.

[40]  R. Nagaraj,et al.  Induction of autophagic cell death in Leishmania donovani by antimicrobial peptides. , 2003, Molecular and biochemical parasitology.

[41]  Xose S. Puente,et al.  Human Autophagins, a Family of Cysteine Proteinases Potentially Implicated in Cell Degradation by Autophagy* , 2003, The Journal of Biological Chemistry.

[42]  D. Perlmutter.  Liver injury in alpha1-antitrypsin deficiency: an aggregated protein induces mitochondrial injury. , 2002, The Journal of clinical investigation.

[43]  G. Fantuzzi,et al.  The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokines , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[44]  A. Progulske-Fox,et al.  Bacterial interactions with the autophagic pathway , 2002, Cellular microbiology.

[45]  J. Dice,et al.  A molecular chaperone complex at the lysosomal membrane is required for protein translocation. , 2001, Journal of cell science.

[46]  Takeshi Tokuhisa,et al.  Dissection of Autophagosome Formation Using Apg5-Deficient Mouse Embryonic Stem Cells , 2001, The Journal of cell biology.

[47]  A. Llorente,et al.  Proteoglycan synthesis is increased in cells with impaired clathrin-dependent endocytosis. , 2001, Journal of cell science.

[48]  K. Williams,et al.  Transmembrane and cytoplasmic domains of syndecan mediate a multi-step endocytic pathway involving detergent-insoluble membrane rafts. , 2000, The Biochemical journal.

[49]  Heinz Schwarz,et al.  Autophagic tubes: vacuolar invaginations involved in lateral membrane sorting and inverse vesicle budding. , 2000 .

[50]  L. Kjeldsen,et al.  Human neutrophil gelatinase-associated lipocalin and homologous proteins in rat and mouse. , 2000, Biochimica et biophysica acta.

[51]  J. Benovic,et al.  Mechanisms of agonist-induced down-regulation of the human kappa-opioid receptor: internalization is required for down-regulation. , 2000, Molecular pharmacology.

[52]  A. Ciechanover,et al.  The ubiquitin system , 2000, Nature Medicine.

[53]  Michael D. George,et al.  Apg5p functions in the sequestration step in the cytoplasm-to-vacuole targeting and macroautophagy pathways. , 2000, Molecular biology of the cell.

[54]  P. van Kerkhof,et al.  Endocytosis and Degradation of the Growth Hormone Receptor Are Proteasome-dependent* , 2000, The Journal of Biological Chemistry.

[55]  A. Cuervo,et al.  Direct lysosomal uptake of α2-microglobulin contributes to chemically induced nephropathy , 1999 .

[56]  P. Allen,et al.  Inhibition of autophagy abrogates tumour necrosis factor α induced apoptosis in human T‐lymphoblastic leukaemic cells , 1997, British journal of haematology.

[57]  G. Daculsi,et al.  Ultrastructural study of degradation of calcium phosphate ceramic by human monocytes and modulation of this activity by HILDA/LIF cytokine. , 1996, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[58]  G. Feldmann,et al.  Inhibition of liver RNA breakdown during acute inflammation in the rat. , 1996, Biochemical Journal.

[59]  A. Meijer,et al.  Phosphorylation of Ribosomal Protein S6 Is Inhibitory for Autophagy in Isolated Rat Hepatocytes (*) , 1995, The Journal of Biological Chemistry.

[60]  G. Miotto,et al.  Inhibition of macroautophagy and proteolysis in the isolated rat hepatocyte by a nontransportable derivative of the multiple antigen peptide Leu8-Lys4-Lys2-Lys-beta Ala. , 1994, The Journal of biological chemistry.

[61]  M. Schlumpberger,et al.  Isolation of autophagocytosis mutants of Saccharomyces cerevisiae , 1994, FEBS letters.

[62]  Y. Ohsumi,et al.  Isolation and characterization of autophagy‐defective mutants of Saccharomyces cerevisiae , 1993, FEBS letters.

[63]  P. Seglen,et al.  Energy dependence of different steps in the autophagic-lysosomal pathway. , 1989, The Journal of biological chemistry.

[64]  L. Tessitore,et al.  Control of Protein Degradation and Growth Phase in Normal and Neoplastic Cells , 1984, Toxicologic pathology.

[65]  A. Cuervo,et al.  Direct lysosomal uptake of alpha 2-microglobulin contributes to chemically induced nephropathy. , 1999, Kidney international.

[66]  E. Claassen,et al.  Antigens and antigen presentation , 1997 .