Biomedical Signal Processing and Control

a b s t r a c t In this paper, motivated by the problem of multimodal retinal image registration, we introduce and improve the robust registration framework based on partial intensity invariant feature descriptor (PIIFD), then present a registration framework based on speed up robust feature (SURF) detector, PIIFD and robust point matching, called SURF–PIIFD–RPM. Existing retinal image registration algorithms are unadaptable to any case, such as complex multimodal images, poor quality, and nonvascular images. Harris-PIIFD framework usually fails in correctly aligning color retinal images with other modalities when faced large content changes. Our proposed registration framework mainly solves the problem robustly. Firstly, SURF detector is useful to extract more repeatable and scale-invariant interest points than Harris. Secondly, a single Gaussian robust point matching model is based on the kernel method of reproducing kernel Hilbert space to estimate mapping function in the presence of outliers. Most importantly, our improved registration framework performs well even when confronted a large number of outliers in the initial correspondence set. Finally, multiple experiments on our 142 multimodal retinal image pairs demonstrate that our SURF–PIIFD–RPM outperforms existing algorithms, and it is quite robust to outliers. © 2015 Elsevier Ltd. All rights reserved.