High expression of Dickkopf‐related protein 1 is related to lymphatic metastasis and indicates poor prognosis in intrahepatic cholangiocarcinoma patients after surgery

Dickkopf‐related protein 1 (DKK1) has been reported involved in metastasis and invasion in several tumors. This study sought to investigate the prognostic value of DKK1 in intrahepatic cholangiocarcinoma (ICC) and its role in promoting ICC metastasis.

[1]  L. Qin,et al.  Validity of plasma macrophage migration inhibitory factor for diagnosis and prognosis of hepatocellular carcinoma , 2011, International journal of cancer.

[2]  T. Janvilisri,et al.  Prognostic value of ABCG2 in moderately and poorly differentiated intrahepatic cholangiocarcinoma , 2011, Histopathology.

[3]  F. Pruvot,et al.  AJCC 7th edition of TNM staging accurately discriminates outcomes of patients with resectable intrahepatic cholangiocarcinoma , 2011, Cancer.

[4]  A. Jemal,et al.  Global Cancer Statistics , 2011 .

[5]  T. Pawlik,et al.  Intrahepatic cholangiocarcinoma: An international, multi-institutional analysis of prognostic factors and lymph node assessment. , 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[6]  S. Qiu,et al.  Up-regulation of Krüppel-like factor 8 promotes tumor invasion and indicates poor prognosis for hepatocellular carcinoma. , 2010, Gastroenterology.

[7]  Quan-lin Li,et al.  Overexpression of CD151 as an adverse marker for intrahepatic cholangiocarcinoma patients , 2010, Cancer.

[8]  Y. Miyagi,et al.  Molecular and Cellular Pathobiology Cancer Research Wnt Inhibitor Dickkopf-1 as a Target for Passive Cancer Immunotherapy , 2010 .

[9]  K. Yorita,et al.  Dickkopf‐1 is overexpressed in human pancreatic ductal adenocarcinoma cells and is involved in invasive growth , 2009, International journal of cancer.

[10]  S. Qiu,et al.  CD24 Is a Novel Predictor for Poor Prognosis of Hepatocellular Carcinoma after Surgery , 2009, Clinical Cancer Research.

[11]  M. Asaka,et al.  Fascin is involved in tumor necrosis factor-α-dependent production of MMP9 in cholangiocarcinoma , 2009, Laboratory Investigation.

[12]  L. Hood,et al.  Elevated expression of DKK1 is associated with cytoplasmic/nuclear beta-catenin accumulation and poor prognosis in hepatocellular carcinomas. , 2009, Journal of hepatology.

[13]  Q. Ye,et al.  Intrahepatic cholangiocarcinoma: report of 272 patients compared with 5,829 patients with hepatocellular carcinoma , 2009, Journal of Cancer Research and Clinical Oncology.

[14]  Y. Maehara,et al.  Fascin overexpression is involved in carcinogenesis and prognosis of human intrahepatic cholangiocarcinoma: immunohistochemical and molecular analysis. , 2009, Human pathology.

[15]  I. Endo,et al.  Intrahepatic cholangiocarcinoma , 2014, Radiopaedia.org.

[16]  Y. Maehara,et al.  Lymphatic spread is related to VEGF-C expression and D2-40-positive myofibroblasts in intrahepatic cholangiocarcinoma , 2008, Modern Pathology.

[17]  Michael L. Wang,et al.  Dickkopf-1 (DKK1) is a widely expressed and potent tumor-associated antigen in multiple myeloma. , 2007, Blood.

[18]  Y. Miyagi,et al.  Dikkopf-1 as a novel serologic and prognostic biomarker for lung and esophageal carcinomas. , 2007, Cancer research.

[19]  S. Turcotte,et al.  The Wnt pathway regulator DKK1 is preferentially expressed in hormone-resistant breast tumours and in some common cancer types , 2007, British Journal of Cancer.

[20]  Y. N. Park,et al.  The Clinicopathologic Significance of the Expression of Vascular Endothelial Growth Factor-C in Intrahepatic Cholangiocarcinoma , 2006, American journal of clinical oncology.

[21]  Kathleen R. Cho,et al.  FGF‐20 and DKK1 are transcriptional targets of β‐catenin and FGF‐20 is implicated in cancer and development , 2005, The EMBO journal.

[22]  K. McGlynn,et al.  Rising incidence of intrahepatic cholangiocarcinoma in the United States: a true increase? , 2004, Journal of hepatology.

[23]  F. Zhan,et al.  The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma. , 2003, The New England journal of medicine.

[24]  K. Okita,et al.  Matrix metalloproteinase-7 and matrix metalloproteinase-9 are associated with unfavourable prognosis in superficial oesophageal cancer , 2003, British Journal of Cancer.

[25]  H. Thomas,et al.  Guidelines for the diagnosis and treatment of cholangiocarcinoma: consensus document , 2002, Gut.

[26]  A. Glinka,et al.  The role of Xenopus dickkopf1 in prechordal plate specification and neural patterning. , 2000, Development.

[27]  A. Jemal,et al.  Global cancer statistics , 2011, CA: a cancer journal for clinicians.

[28]  C. Niehrs,et al.  Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction , 1998, Nature.