Hyperhomocysteinemia induces a tissue specific accumulation of homocysteine in bone by collagen binding and adversely affects bone.

[1]  A. Hamfelt.  Enzymatic determination of pyridoxal phosphate in plasma by decarboxylation of L-tyrosine-14 C (U) and a comparison with the tryptophan load test. , 1967, Scandinavian journal of clinical and laboratory investigation.

[2]  Victor A. McKusick,et al.  Heritable disorders of connective tissue , 1972 .

[3]  A. Kang,et al.  A collagen defect in homocystinuria. , 1973, The Journal of clinical investigation.

[4]  M. Drezner,et al.  Bone histomorphometry: Standardization of nomenclature, symbols, and units: Report of the asbmr histomorphometry nomenclature committee , 1987, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[5]  S. Mudd.  Disorders of transsulfuration , 1989 .

[6]  E. Haber,et al.  Inhibition of Growth and p21 ras Methylation in Vascular Endothelial Cells by Homocysteine but Not Cysteine* , 1997, The Journal of Biological Chemistry.

[7]  J. Finkelstein,et al.  The metabolism of homocysteine: pathways and regulation , 1998, European Journal of Pediatrics.

[8]  Hong Wang,et al.  Homocysteine and hypomethylation. A novel link to vascular disease. , 1999, Trends in cardiovascular medicine.

[9]  J. Finkelstein,et al.  Pathways and Regulation of Homocysteine Metabolism in Mammals , 2000, Seminars in thrombosis and hemostasis.

[10]  I. Pogribny,et al.  Intracellular S-adenosylhomocysteine concentrations predict global DNA hypomethylation in tissues of methyl-deficient cystathionine beta-synthase heterozygous mice. , 2001, The Journal of nutrition.

[11]  C. Cooper,et al.  Recent developments in the epidemiology of osteoporosis , 2002, Current opinion in rheumatology.

[12]  S. Sengupta,et al.  Homocysteine Binds to Human Plasma Fibronectin and Inhibits Its Interaction With Fibrin , 2002, Arteriosclerosis, thrombosis, and vascular biology.

[13]  L. Fink,et al.  Hyperhomocysteinemia leads to adverse cardiac remodeling in hypertensive rats. , 2002, American journal of physiology. Heart and circulatory physiology.

[14]  S. Cummings,et al.  Epidemiology and outcomes of osteoporotic fractures , 2002, The Lancet.

[15]  L. Melton,et al.  Adverse Outcomes of Osteoporotic Fractures in the General Population , 2003, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[16]  M. Hauer-Jensen,et al.  Hyperhomocysteinemia leads to pathological ventricular hypertrophy in normotensive rats. , 2003, American journal of physiology. Heart and circulatory physiology.

[17]  S. Sengupta,et al.  In Vitro and in Vivo Interactions of Homocysteine with Human Plasma Transthyretin* , 2003, Journal of Biological Chemistry.

[18]  K. Lippuner,et al.  Epidemiology and direct medical costs of osteoporotic fractures in men and women in Switzerland , 2005, Osteoporosis International.

[19]  D. Kiel,et al.  Homocysteine as a predictive factor for hip fracture in older persons. , 2004, The New England journal of medicine.

[20]  A. Hofman,et al.  Homocysteine levels and the risk of osteoporotic fracture. , 2004, The New England journal of medicine.

[21]  A. Zallone,et al.  Increased osteoclast activity in the presence of increased homocysteine concentrations. , 2005, Clinical chemistry.

[22]  A. Perna,et al.  Hyperhomocysteinemia and macromolecule modifications in uremic patients , 2005, Clinical chemistry and laboratory medicine.

[23]  H. Blom,et al.  Stable-isotope dilution liquid chromatography-electrospray injection tandem mass spectrometry method for fast, selective measurement of S-adenosylmethionine and S-adenosylhomocysteine in plasma. , 2005, Clinical chemistry.

[24]  C. Woo,et al.  Homocysteine Activates cAMP-response Element Binding Protein in HepG2 Through cAMP/PKA Signaling Pathway , 2006, Arteriosclerosis, thrombosis, and vascular biology.

[25]  J. Park,et al.  Homocysteine enhances apoptosis in human bone marrow stromal cells. , 2006, Bone.

[26]  D. Jacobsen.  Homocysteine targeting of plasma proteins in hemodialysis patients. , 2006, Kidney international.

[27]  M. Saito,et al.  Degree of Mineralization-related Collagen Crosslinking in the Femoral Neck Cancellous Bone in Cases of Hip Fracture and Controls , 2006, Calcified Tissue International.

[28]  Hong-Hee Kim,et al.  Homocysteine Enhances Bone Resorption by Stimulation of Osteoclast Formation and Activity Through Increased Intracellular ROS Generation , 2006, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[29]  A. Zallone,et al.  Stimulation of osteoclast activity by low B-vitamin concentrations. , 2007, Bone.

[30]  D. Jacobsen,et al.  Targeting of Metallothionein by L-Homocysteine: A Novel Mechanism for Disruption of Zinc and Redox Homeostasis , 2007, Arteriosclerosis, thrombosis, and vascular biology.

[31]  A. Tasatargil,et al.  Experimental hyperhomocysteinemia disturbs bone metabolism in rats , 2007, Scandinavian journal of clinical and laboratory investigation.

[32]  Hong Wang,et al.  Homocysteine inhibits endothelial cell growth via DNA hypomethylation of the cyclin A gene. , 2007, Blood.

[33]  R. Diaz-Arrastia,et al.  Protein Phosphatase 2A Methyltransferase Links Homocysteine Metabolism with Tau and Amyloid Precursor Protein Regulation , 2007, The Journal of Neuroscience.

[34]  L. Claes,et al.  Experimental hyperhomocysteinemia reduces bone quality in rats. , 2007, Clinical chemistry.

[35]  J. Finkelstein,et al.  Metabolic regulatory properties of S-adenosylmethionine and S-adenosylhomocysteine , 2007, Clinical chemistry and laboratory medicine.

[36]  W. Herrmann,et al.  The role of hyperhomocysteinemia as well as folate, vitamin B6 and B12 deficiencies in osteoporosis – a systematic review , 2007, Clinical chemistry and laboratory medicine.

[37]  A. Zallone,et al.  Accumulation of homocysteine by decreasing concentrations of folate, vitamin B12 and B6 does not influence the activity of human osteoblasts in vitro. , 2007, Clinica chimica acta; international journal of clinical chemistry.

[38]  D. Jacobsen,et al.  Molecular targeting of proteins by L-homocysteine: mechanistic implications for vascular disease. , 2007, Antioxidants & redox signaling.

[39]  A. Zallone,et al.  Stimulation of osteoblast activity by homocysteine , 2008, Journal of cellular and molecular medicine.

[40]  J. Kanis,et al.  Osteoporosis update 1997 , 2010, Osteoporosis International.