Monitoring SAW-actuated microdroplets in view of biological applications

Droplet localization is of primary importance in (Surface Acoustic Wave) SAW-actuated droplet manipulation for the blind-control of digital microfluidics in lab-on-chips (LOC). This issue is addressed by reconsidering hereafter the implementation of our already published SAW echo method. Two echo signals are now recorded: one for the droplet at its initial known position and one for the droplet at its new unknown position after displacement. Subtracting the delays of the 2 echoes leads to an accurate determination of the unknown position provided that the droplet characteristics remain identical for the 2 considered positions. No detailed analysis of the SAW scattering by the droplet is required with this new protocol. For implementing this echo-localization method, we propose a specific LOC architecture along with software monitoring, suitable for biological applications and devoted here to protein analysis by MALDI mass spectrometry.

[1]  Christian Druon,et al.  SAW nanopump for handling droplets in view of biological applications , 2006 .

[2]  P. Helin,et al.  Theoretical and experimental study of linear motors using surface acoustic waves , 1998 .

[3]  James Friend,et al.  Particle concentration and mixing in microdrops driven by focused surface acoustic waves , 2008 .

[4]  Leslie Y Yeo,et al.  Microfluidic colloidal island formation and erasure induced by surface acoustic wave radiation. , 2008, Physical review letters.

[5]  Vicki Hinson-Smith,et al.  The new era of SAW devices , 2006 .

[6]  V. Krylov,et al.  Surface acoustic wave resonances in the spreading of viscous fluids , 1999 .

[7]  Achim Wixforth,et al.  Carbon nanotube alignment by surface acoustic waves , 2004 .

[8]  Achim Wixforth,et al.  Acoustic mixing at low Reynold's numbers , 2006 .

[9]  Leslie Y Yeo,et al.  Surface acoustic wave concentration of particle and bioparticle suspensions , 2007, Biomedical microdevices.

[10]  Roland Zengerle,et al.  Microfluidic platforms for lab-on-a-chip applications. , 2007, Lab on a chip.

[11]  Christian Druon,et al.  Surface acoustic wave two-dimensional transport and location of microdroplets using echo signal , 2006 .

[12]  David Quéré,et al.  Gouttes, bulles, perles et ondes , 2005 .

[13]  Achim Wixforth,et al.  Alignment of carbon nanotubes on pre-structured silicon by surface acoustic waves , 2006 .

[14]  Tsung-Tsong Wu,et al.  Actuating and detecting of microdroplet using slanted finger interdigital transducers , 2005 .

[15]  Gwo-Bin Lee,et al.  Active micro-mixers using surface acoustic waves on Y-cut 128° LiNbO3 , 2006 .

[16]  Richard B. Fair,et al.  Digital microfluidics: is a true lab-on-a-chip possible? , 2007 .

[17]  S. Shiokawa,et al.  Liquid heating effects by SAW streaming on the piezoelectric substrate , 2005, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[18]  Leslie Y Yeo,et al.  Microparticle collection and concentration via a miniature surface acoustic wave device. , 2007, Lab on a chip.

[19]  T. Higuchi,et al.  Characteristics of liquids atomization using surface acoustic wave , 1997, Proceedings of International Solid State Sensors and Actuators Conference (Transducers '97).

[20]  A. Wixforth,et al.  Planar chip device for PCR and hybridization with surface acoustic wave pump. , 2005, Lab on a chip.

[21]  James Friend,et al.  Interfacial destabilization and atomization driven by surface acoustic waves , 2008 .

[22]  Minoru Kurosawa,et al.  Nano meter stepping drive of surface acoustic wave motor , 2001, Proceedings of the 2001 1st IEEE Conference on Nanotechnology. IEEE-NANO 2001 (Cat. No.01EX516).

[23]  Achim Wixforth,et al.  Acoustic manipulation of small droplets , 2004, Analytical and bioanalytical chemistry.

[24]  S. Shiokawa,et al.  The Dynamics of SAW Streaming and its Application to Fluid Devices , 1994 .

[25]  Omar Elmazria,et al.  Microfluidic device based on surface acoustic wave , 2006 .

[26]  S. Shiokawa,et al.  Development of Novel Atomization System Based on SAW Streaming , 2004 .

[27]  S. Cho,et al.  Creating, transporting, cutting, and merging liquid droplets by electrowetting-based actuation for digital microfluidic circuits , 2003 .

[28]  S. Alzuaga,et al.  A large scale X-Y positioning and localisation system of liquid droplet using SAW on LiNbO/sub 3/ , 2003, IEEE Symposium on Ultrasonics, 2003.

[29]  Jürgen Scriba,et al.  Planar microfluidic processors , 2002, 2002 IEEE Ultrasonics Symposium, 2002. Proceedings..