The L3 loop: a structural motif determining specific interactions between SMAD proteins and TGF‐β receptors
暂无分享,去创建一个
Yigong Shi | J. Massagué | Yigong Shi | N. Pavletich | R. Lo | Ye Guang Chen | Joan Massagué | Roger S. Lo | Ye‐Guang Chen | Nikola P. Pavletich | Ye-Guang Chen
[1] C. J. Gimeno,et al. Vascular MADs: two novel MAD-related genes selectively inducible by flow in human vascular endothelium. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[2] K. Miyazono,et al. Smad6 inhibits signalling by the TGF-beta superfamily. , 1997, Nature.
[3] Scott E. Kern,et al. DPC4, A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1 , 1996, Science.
[4] Irene L Andrulis,et al. MADR2 Maps to 18q21 and Encodes a TGFβ–Regulated MAD–Related Protein That Is Functionally Mutated in Colorectal Carcinoma , 1996, Cell.
[5] J. Massagué,et al. Transforming growth factor-beta inhibition of epithelial cell proliferation linked to the expression of a 53-kDa membrane receptor. , 1989, The Journal of biological chemistry.
[6] J. Massagué,et al. Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor. , 1998, Genes & development.
[7] Richard Treisman,et al. Transcriptional Regulation by Extracellular signals: Mechanisms and Specificity , 1995, Cell.
[8] W. Gelbart,et al. Mothers against dpp participates in a DDP/TGF-beta responsive serine-threonine kinase signal transduction cascade. , 1997, Development.
[9] W. Vale,et al. Smad8 mediates the signaling of the receptor serine kinase , 1997 .
[10] Xiao-Fan Wang,et al. Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growth. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[11] J. Massagué. TGFβ Signaling: Receptors, Transducers, and Mad Proteins , 1996, Cell.
[12] J. Massagué,et al. Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4 , 1997, Nature.
[13] P. Hoodless,et al. MADR1, a MAD-Related Protein That Functions in BMP2 Signaling Pathways , 1996, Cell.
[14] R. Derynck,et al. Heteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4 , 1997, Molecular and cellular biology.
[15] Minoru Watanabe,et al. Smad4 and FAST-1 in the assembly of activin-responsive factor , 1997, Nature.
[16] J. Wrana,et al. The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ Signaling , 1997, Cell.
[17] Kirby D. Johnson,et al. Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic , 1997, Nature.
[18] T. Musci,et al. The tumor suppressor Smad4/DPC 4 as a central mediator of Smad function , 1997, Current Biology.
[19] R. Lotan,et al. DPC4, a candidate tumor suppressor gene, is altered infrequently in head and neck squamous cell carcinoma. , 1996, Cancer research.
[20] R. Derynck,et al. Receptor-associated Mad homologues synergize as effectors of the TGF-β response , 1996, Nature.
[21] A. Hata,et al. TGF-β signalling through the Smad pathway , 1997 .
[22] J. Baker,et al. A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway. , 1996, Genes & development.
[23] J. Wrana,et al. MAD-related proteins in TGF-β signalling , 1996 .
[24] G. Thomsen. Xenopus mothers against decapentaplegic is an embryonic ventralizing agent that acts downstream of the BMP-2/4 receptor. , 1996, Development.
[25] J. Massagué,et al. The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase. , 1997, Genes & development.
[26] C. Heldin,et al. Identification of Smad2, a Human Mad-related Protein in the Transforming Growth Factor β Signaling Pathway* , 1997, The Journal of Biological Chemistry.
[27] J. Massagué,et al. Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways , 1996, Nature.
[28] J. Graff,et al. Xenopus Mad Proteins Transduce Distinct Subsets of Signals for the TGFβ Superfamily , 1996, Cell.
[29] P. Hoodless,et al. MADR2 Is a Substrate of the TGFβ Receptor and Its Phosphorylation Is Required for Nuclear Accumulation and Signaling , 1996, Cell.
[30] Yigong Shi,et al. A structural basis for mutational inactivation of the tumour suppressor Smad4 , 1997, Nature.
[31] J. Massagué,et al. A human Mad protein acting as a BMP-regulated transcriptional activator , 1996, Nature.
[32] T. Lecuit,et al. Mad acts downstream of Dpp receptors, revealing a differential requirement for dpp signaling in initiation and propagation of morphogenesis in the Drosophila eye. , 1996, Development.
[33] R. W. Padgett,et al. Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor beta pathway components. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[34] J. Massagué,et al. Mechanism of TGFβ receptor inhibition by FKBP12 , 1997, The EMBO journal.
[35] H. Hishigaki,et al. Cloning and characterization of a novel member of the human Mad gene family (MADH6). , 1997, Genomics.
[36] T. Pawson,et al. Signaling through scaffold, anchoring, and adaptor proteins. , 1997, Science.
[37] C. Heldin,et al. Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling , 1997, Nature.
[38] C. Heldin,et al. Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling. , 1997, Nature.
[39] J. Massagué. [17] Identification of receptor for type-β transforming growth factor , 1987 .
[40] K. Miyazono,et al. Smad6 inhibits signalling by the TGF-β superfamily , 1997, Nature.
[41] R. Derynck,et al. Intracellular signalling: The Mad way to do it , 1996, Current Biology.
[42] T. Tabata,et al. Daughters against dpp modulates dpp organizing activity in Drosophila wing development , 1997, Nature.
[43] J. Sekelsky,et al. Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster. , 1995, Genetics.
[44] M. Kretzschmar,et al. Opposing BMP and EGF signalling pathways converge on the TGF-β family mediator Smad1 , 1997, Nature.
[45] J. Massagué,et al. Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes. , 1997, Genes & development.
[46] J. Massagué,et al. Smad 6 inhibits BMP / Smad 1 signaling by specifically competing with the Smad 4 tumor suppressor , 1998 .