The role of the right parietal lobe in the perception of causality: a tDCS study

Inferring causality is a fundamental feature of human cognition that allows us to predict outcomes in everyday events. Here, we use direct current stimulation (tDCS) to investigate the role of the right parietal lobe in the perception of causal events. Based on the results of a previous fMRI investigation, we hypothesized that the right parietal lobe plays a specific role in the processing of spatial attributes that contribute to judgments of causality. In line with our hypothesis, we found polarization-dependent modulation of causal judgments and corresponding reaction times (RTs) for trials with increasing violation of spatial contiguity in launching events. This effect was further modulated by temporal violations, as the effect of tDCS on the use of spatial information for causality judgements was strongest for trials with high temporal violations. Thus, especially for ambiguous trials with regard to temporal patterns, cathodal stimulation led to more liberal causality judgments for trials with high angles in movement trajectory. Furthermore, we found faster RTs after anodal stimulation of the right parietal lobe. These findings suggest a reduced influence of spatial attributes on the perception of causality after cathode stimulation of the right parietal lobe and an increased processing efficiency after anodal stimuli of the same region. These data demonstrate polarization-dependent tDCS modulation of spatial processing mechanisms within the right parietal lobe that contribute to the perception of causality.

[1]  A. Chatterjee,et al.  Space and Time in Perceptual Causality , 2010, Front. Hum. Neurosci..

[2]  Á. Pascual-Leone,et al.  Diminishing Risk-Taking Behavior by Modulating Activity in the Prefrontal Cortex: A Direct Current Stimulation Study , 2007, The Journal of Neuroscience.

[3]  Jonathan A. Fugelsang,et al.  Dissociating processes supporting causal perception and causal inference in the brain. , 2005, Neuropsychology.

[4]  P. Enticott,et al.  Improving working memory: the effect of combining cognitive activity and anodal transcranial direct current stimulation to the left dorsolateral prefrontal cortex , 2011, Brain Stimulation.

[5]  M. Nitsche,et al.  Pharmacological approach to the mechanisms of transcranial DC-stimulation-induced after-effects of human motor cortex excitability. , 2002, Brain : a journal of neurology.

[6]  A. Michotte.  The perception of causality , 1963 .

[7]  Jean M. Vettel,et al.  Visual motion and the neural correlates of event perception , 2006, Brain Research.

[8]  Mary Hegarty,et al.  Modulation of neural activity by angle of rotation during imagined spatial transformations , 2006, NeuroImage.

[9]  S. Cappa,et al.  Improved naming after transcranial direct current stimulation in aphasia , 2007, Journal of Neurology, Neurosurgery, and Psychiatry.

[10]  J. Krakauer,et al.  Consensus: Can transcranial direct current stimulation and transcranial magnetic stimulation enhance motor learning and memory formation? , 2008, Brain Stimulation.

[11]  Walter Paulus,et al.  Bidirectional modulation of primary visual cortex excitability: a combined tDCS and rTMS study. , 2007, Investigative ophthalmology & visual science.

[12]  N. Bolognini,et al.  Enhancing multisensory spatial orienting by brain polarization of the parietal cortex , 2010, The European journal of neuroscience.

[13]  George A. Alvarez,et al.  The Role of the Parietal Lobe in Visual Extinction Studied with Transcranial Magnetic Stimulation , 2009, Journal of Cognitive Neuroscience.

[14]  F. Fregni,et al.  Temporal cortex direct current stimulation enhances performance on a visual recognition memory task in Alzheimer disease , 2008, Journal of Neurology, Neurosurgery, and Psychiatry.

[15]  Alvaro Pascual-Leone,et al.  Effects of transcranial direct current stimulation on working memory in patients with Parkinson's disease , 2006, Journal of the Neurological Sciences.

[16]  S. Sato,et al.  Safety and cognitive effect of frontal DC brain polarization in healthy individuals , 2005, Neurology.

[17]  Jonathan A. Fugelsang,et al.  Brain mechanisms underlying perceptual causality. , 2005, Brain research. Cognitive brain research.

[18]  Sara Marceglia,et al.  Cerebellar Transcranial Direct Current Stimulation Impairs the Practice-dependent Proficiency Increase in Working Memory , 2008, Journal of Cognitive Neuroscience.

[19]  G. Fink,et al.  Bidirectional alterations of interhemispheric parietal balance by non-invasive cortical stimulation. , 2009, Brain : a journal of neurology.

[20]  Sergio P. Rigonatti,et al.  Repeated sessions of noninvasive brain DC stimulation is associated with motor function improvement in stroke patients. , 2007, Restorative neurology and neuroscience.

[21]  K. Hoffmann,et al.  Direct Current Stimulation over V5 Enhances Visuomotor Coordination by Improving Motion Perception in Humans , 2004, Journal of Cognitive Neuroscience.

[22]  Michele T. Diaz,et al.  The influence of emotional distraction on verbal working memory: an fMRI investigation comparing individuals with schizophrenia and healthy adults. , 2011, Journal of psychiatric research.

[23]  Á. Pascual-Leone,et al.  Modulation of risk-taking in marijuana users by transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex (DLPFC). , 2010, Drug and alcohol dependence.

[24]  M. Corbetta,et al.  Right Hemisphere Dominance during Spatial Selective Attention and Target Detection Occurs Outside the Dorsal Frontoparietal Network , 2010, The Journal of Neuroscience.

[25]  Alexander Münchau,et al.  Premotor transcranial direct current stimulation (tDCS) affects primary motor excitability in humans , 2008, The European journal of neuroscience.

[26]  Á. Pascual-Leone,et al.  Modulation of decision‐making in a gambling task in older adults with transcranial direct current stimulation , 2010, The European journal of neuroscience.

[27]  Michel Terraza,et al.  Testing for Causality , 1994 .

[28]  J. Born,et al.  Transcranial Direct Current Stimulation during Sleep Improves Declarative Memory , 2004, The Journal of Neuroscience.

[29]  Jan Born,et al.  Transcranial Electrical Currents to Probe EEG Brain Rhythms and Memory Consolidation during Sleep in Humans , 2011, PloS one.

[30]  M. Nitsche,et al.  Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation , 2000, The Journal of physiology.

[31]  Paolo Maria Rossini,et al.  Naming facilitation induced by transcranial direct current stimulation , 2010, Behavioural Brain Research.

[32]  Nam-Jong Paik,et al.  Improved picture naming in aphasia patients treated with cathodal tDCS to inhibit the right Broca's homologue area. , 2011, Restorative neurology and neuroscience.

[33]  Alvaro Pascual-Leone,et al.  Temporal Lobe Cortical Electrical Stimulation during the Encoding and Retrieval Phase Reduces False Memories , 2009, PloS one.

[34]  C. V. van Heugten,et al.  The reliability and validity of the PALOC-s: A Post-Acute Level of Consciousness scale for assessment of young patients with prolonged disturbed consciousness after brain injury , 2009, Neuropsychological rehabilitation.

[35]  Sergio P. Rigonatti,et al.  Enhancement of non-dominant hand motor function by anodal transcranial direct current stimulation , 2006, Neuroscience Letters.

[36]  D. Liebetanz,et al.  MRI study of human brain exposed to weak direct current stimulation of the frontal cortex , 2004, Clinical Neurophysiology.

[37]  A. Schlottmann,et al.  Perceived physical and social causality in animated motions: spontaneous reports and ratings. , 2006, Acta psychologica.

[38]  Á. Pascual-Leone,et al.  Studying the neurobiology of social interaction with transcranial direct current stimulation--the example of punishing unfairness. , 2008, Cerebral cortex.

[39]  Neil G. Muggleton,et al.  Modulating inhibitory control with direct current stimulation of the superior medial frontal cortex , 2011, NeuroImage.

[40]  Walter Paulus,et al.  Transcranial Direct Current Stimulation and Visual Perception , 2008, Perception.

[41]  Myoung-Hwan Ko,et al.  Improvement of visual scanning after DC brain polarization of parietal cortex in stroke patients with spatial neglect , 2008, Neuroscience Letters.

[42]  L. Cohen,et al.  Facilitating skilled right hand motor function in older subjects by anodal polarization over the left primary motor cortex , 2010, Neurobiology of Aging.

[43]  P. Fonlupt.  Perception and judgement of physical causality involve different brain structures. , 2003, Brain research. Cognitive brain research.

[44]  Walter Paulus,et al.  Transcranial direct current stimulation and the visual cortex , 2006, Brain Research Bulletin.

[45]  Walter Paulus,et al.  Facilitation of probabilistic classification learning by transcranial direct current stimulation of the prefrontal cortex in the human , 2004, Neuropsychologia.

[46]  N. Bolognini,et al.  Brain polarization of parietal cortex augments training-induced improvement of visual exploratory and attentional skills , 2010, Brain Research.

[47]  N. Birbaumer,et al.  Enhancement of Planning Ability by Transcranial Direct Current Stimulation , 2009, The Journal of Neuroscience.

[48]  Walter Paulus,et al.  Timing-Dependent Modulation of Associative Plasticity by General Network Excitability in the Human Motor Cortex , 2007, The Journal of Neuroscience.

[49]  M. Corbetta,et al.  Areas Involved in Encoding and Applying Directional Expectations to Moving Objects , 1999, The Journal of Neuroscience.

[50]  Sergio P. Rigonatti,et al.  Anodal transcranial direct current stimulation of prefrontal cortex enhances working memory , 2005, Experimental Brain Research.

[51]  R. Miall,et al.  Brain activation patterns during measurement of sub- and supra-second intervals , 2003, Neuropsychologia.

[52]  Pascal Boyer,et al.  How the brain perceives causality: an event-related fMRI study , 2001, Neuroreport.

[53]  David Hume.  A Treatise of Human Nature: Being an Attempt to introduce the experimental Method of Reasoning into Moral Subjects , 1972 .

[54]  Patrick Ragert,et al.  Improvement of spatial tactile acuity by transcranial direct current stimulation , 2008, Clinical Neurophysiology.

[55]  Denise H. Wu,et al.  Neural substrates of processing path and manner information of a moving event , 2008, Neuropsychologia.

[56]  Walter Paulus,et al.  Consolidation of Human Motor Cortical Neuroplasticity by D-Cycloserine , 2004, Neuropsychopharmacology.

[57]  Wolfgang Tschacher,et al.  Perception of causality in schizophrenia spectrum disorder. , 2006, Schizophrenia bulletin.

[58]  Nadia Bolognini,et al.  Behavioural facilitation following brain stimulation: Implications for neurorehabilitation , 2011, Neuropsychological rehabilitation.

[59]  Warren H Meck,et al.  Cortico-striatal Representation of Time in Animals and Humans This Review Comes from a Themed Issue on Cognitive Neuroscience Edited Evidence from Patient Populations and Electrical Potentials Neuroimaging Evidence Using Fmri and Pet , 2022 .

[60]  Simon B Eickhoff,et al.  Brain regions involved in human movement perception: A quantitative voxel‐based meta‐analysis , 2012, Human brain mapping.

[61]  Walter Paulus,et al.  Catecholaminergic consolidation of motor cortical neuroplasticity in humans. , 2004, Cerebral cortex.

[62]  S. Jang,et al.  The enhanced cortical activation induced by transcranial direct current stimulation during hand movements , 2011, Neuroscience Letters.

[63]  M. Nitsche,et al.  Excitability changes induced in the human primary visual cortex by transcranial direct current stimulation: direct electrophysiological evidence. , 2004, Investigative ophthalmology & visual science.

[64]  M. Nitsche,et al.  Physiological Basis of Transcranial Direct Current Stimulation , 2011, The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry.

[65]  Keith J Holyoak,et al.  An fMRI study of causal judgments , 2005, The European journal of neuroscience.

[66]  Karl R. Gegenfurtner,et al.  Cortical networks for motion processing: Effects of focal brain lesions on perception of different motion types , 2009, Neuropsychologia.

[67]  Gereon R. Fink,et al.  Enhancing language performance with non-invasive brain stimulation—A transcranial direct current stimulation study in healthy humans , 2008, Neuropsychologia.

[68]  P. Matthews,et al.  Polarity and timing-dependent effects of transcranial direct current stimulation in explicit motor learning , 2011, Neuropsychologia.

[69]  Á. Pascual-Leone,et al.  Enhanced visual spatial attention ipsilateral to rTMS-induced 'virtual lesions' of human parietal cortex , 2001, Nature Neuroscience.

[70]  A. Valero-Cabré,et al.  Cathodal transcranial direct current stimulation on posterior parietal cortex disrupts visuo-spatial processing in the contralateral visual field , 2008, Experimental Brain Research.

[71]  L. Cohen,et al.  Transcranial DC stimulation (tDCS): A tool for double-blind sham-controlled clinical studies in brain stimulation , 2006, Clinical Neurophysiology.

[72]  J. Krakauer,et al.  Consensus: "Can tDCS and TMS enhance motor learning and memory formation?" , 2008, Brain stimulation.

[73]  Ingo G. Meister,et al.  Interhemispheric imbalance during visuospatial attention investigated by unilateral and bilateral TMS over human parietal cortices , 2006, Brain Research.

[74]  Patrice D. Tremoulet,et al.  Perceptual causality and animacy , 2000, Trends in Cognitive Sciences.

[75]  G. Schlaug,et al.  Testing for causality with transcranial direct current stimulation: pitch memory and the left supramarginal gyrus , 2006, Neuroreport.

[76]  M. Nitsche,et al.  Safety criteria for transcranial direct current stimulation (tDCS) in humans , 2003, Clinical Neurophysiology.

[77]  M. Nitsche,et al.  Modulating parameters of excitability during and after transcranial direct current stimulation of the human motor cortex , 2005, Clinical Neurophysiology.

[78]  B. Fierro,et al.  Neglect-like effects induced by tDCS modulation of posterior parietal cortices in healthy subjects , 2011, Brain Stimulation.

[79]  Ingrid R. Olson,et al.  A selective working memory impairment after transcranial direct current stimulation to the right parietal lobe , 2010, Neuroscience Letters.

[80]  Sung Ho Jang,et al.  Facilitating visuospatial attention for the contralateral hemifield by repetitive TMS on the posterior parietal cortex , 2005, Neuroscience Letters.