Analog transistor models of bacterial genetic circuits

We show that compact analog current-mode circuits are effective at quantitatively modeling the behavior of genetic circuits. We present experimental biological data from genetic activator (PBAD) and repressor (PlacO) promoter circuits in E. coli. Simple subthreshold cascaded-differential-pair transistor circuits have input-output characteristics that quantitatively represent this data. Such foundational analog circuits can provide efficient conceptual, modeling, and simulation tools for the design and analysis of circuits in synthetic and systems biology.

[1]  G. K. Ackers,et al.  Quantitative model for gene regulation by lambda phage repressor. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[2]  Soumyajit Mandal,et al.  Circuit models of stochastic genetic networks , 2009, 2009 IEEE Biomedical Circuits and Systems Conference.

[3]  Rahul Sarpeshkar.  Ultra Low Power Bioelectronics: Cytomorphic electronics: cell-inspired electronics for systems and synthetic biology , 2010 .

[4]  Uri Alon,et al.  An Introduction to Systems Biology , 2006 .

[5]  Soumyajit Mandal,et al.  Log-domain circuit models of chemical reactions , 2009, 2009 IEEE International Symposium on Circuits and Systems.

[6]  G. Yarrington.  Molecular Cell Biology , 1987, The Yale Journal of Biology and Medicine.